Gait dynamics in mouse models of Parkinson's disease and Huntington's disease

Amende, Ivo; Kale, Ajit; McCue, Scott; Glazier, Scott; Morgan, James P.; Hampton, Thomas G.

doi:10.1186/1743-0003-2-20

Cited by 149 publications

(116 citation statements)

References 72 publications

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“…Additionally, these treadmill-based analyses of gait have been conducted within 24 hr of final MPTP injection, whereas the current study examines deficit 10 days later. One acute MPTP study found decreased stride length and increased stride frequency using the DigiGait treadmill, similar to the trend observed in the current study (Amende et al, 2005, their Table 1). Stride duration was decreased to a greater extent in progressively treated MPTP animals compared with these acute studies, resulting in a trend similar to that of acute MPTP treatment but with a significant outcome.…”

Section: Progressive Mptp Leads To Lasting Changes In Multiple Gait Dsupporting

confidence: 93%

“…Several studies have reported the use of the DigiGait gait analysis system in acutely MPTP-treated mice (Amende et al, 2005;Rommelfanger et al, 2007); however, this is the first report using a progressive paradigm. Additionally, these treadmill-based analyses of gait have been conducted within 24 hr of final MPTP injection, whereas the current study examines deficit 10 days later.…”

Section: Progressive Mptp Leads To Lasting Changes In Multiple Gait Dmentioning

confidence: 95%

“…With the DigiGait treadmill from Mouse Specifics (Quincy, MA), gait dynamics have been reported in acute MPTP mouse models of PD (Amende et al, 2005;Rommelfanger et al, 2007). However, we are the first to report the utility of the DigiGait treadmill in assessing gait dynamics in mice receiving progressively increased MPTP following a 10-day washout period.…”

mentioning

confidence: 90%

“…Ventral plane videography, as previously described, captured the gait of each mouse through a transparent, motor-driven treadmill belt (Kale et al, 2004;Amende et al, 2005). Digital images of the paws of each mouse were taken at 150 frames/sec as mice walked at a speed of 24 cm/sec.…”

Section: Gait Dynamicsmentioning

confidence: 99%

“…Temporal and spatial measurements were indicated by the area of the paw relative to the treadmill belt at each frame. Stride length, stride frequency, total number of steps taken, stride duration, variability in stride length and paw area, and propulsion were analyzed as previously described (Amende et al, 2005).…”

Section: Gait Dynamicsmentioning

confidence: 99%

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Profiling changes in gait dynamics resulting from progressive 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced nigrostriatal lesioning

Goldberg

Hampton

McCue

et al. 2011

J of Neuroscience Research

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Current behavioral measurements for motor impairment are not consistently sensitive in rodent models of partial nigrostriatal dopamine (DA) depletion. In addition to exploratory and somatosensory behavior, motor skills that are thought to be directly translatable to human Parkinson's disease patients are assessed. However, many of these motor tests require the training and learning of particular tasks, so it cannot be determined whether impairments are due to motor or to learning deficit. Therefore, we have quantified multiple temporal and spatial indices of gait dynamics in a model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced partial nigrostriatal lesioning using a treadmill apparatus requiring no prior training. Three days following the cessation of progressively increased MPTP administration, rearing and foot-fault behaviors showed significant deficit. Ten days after the final MPTP injection, gait dynamics were assessed and indicated differences between MPTP- and vehicle-treated animals. The major significant changes were in stride length, frequency, duration, and number of steps. Three weeks following a progressively increased dose of MPTP (administered 5 days per week over the course of 4 weeks), mice showed a 63% decrease in tyrosine hydroxylase-immunoreactive (TH-ir) nigrostriatal neurons in the substantia nigra pars compacta and a 72% decrease in TH-ir terminals in the caudate-putamen. This suggests that there is a continued effect of progressively increased MPTP on nigrostriatal DA neurons, correlated with rearing and foot-fault behaviors and further characterized by differences in temporal and spatial measurements of gait dynamics.

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Section: Progressive Mptp Leads To Lasting Changes In Multiple Gait Dsupporting

confidence: 93%

Section: Progressive Mptp Leads To Lasting Changes In Multiple Gait Dmentioning

confidence: 95%

mentioning

confidence: 90%

Section: Gait Dynamicsmentioning

confidence: 99%

Section: Gait Dynamicsmentioning

confidence: 99%

See 3 more Smart Citations

Profiling changes in gait dynamics resulting from progressive 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced nigrostriatal lesioning

Goldberg

Hampton

McCue

et al. 2011

J of Neuroscience Research

Self Cite

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Assessment of Motor Coordination and Balance in Mice Using the Rotarod, Elevated Bridge, and Footprint Tests

Brooks¹,

Trueman²,

Dunnett³

2012

CP Mouse Biology

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In order fully to utilize animal models of disease states, to test experimental therapeutics, and to understand the underlying pathophysiology of neurodegenerative disease, behavioral characterization of the model is essential. Deterioration of normal motor function within a disease state signals the progression of an underlying pathological process, and identifies disease-sensitive time points according to which the onset of therapeutic trials may be scheduled. Deterioration in the performance of motor tasks may also indicate the point when motor deficits begin to compromise our ability to measure other deficits within cognitive and behavioral domains. In acute therapeutic trials, the separation of motor from cognitive or behavioral function may be crucial in determining the functional specificity of the drug effect. If we are to accurately measure motor performance in disease progression or during drug trials, tests of motor function that have been highly optimized with respect to sensitivity must be applied. Since motor coordination and balance are essential to normal motor function, tests that probe these facets are ideal for the purpose. In this chapter, we describe in detail three test protocols that principally measure motor coordination (the rotarod and footprint tests) and balance (the elevated bridge test) in mice. Curr. Protoc. Mouse Biol. 2:37-53 © 2012 by John Wiley & Sons, Inc.

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Protective and Damaging Mechanisms of Neuromelanin‐Like Nanoparticles and Iron in Parkinson's Disease

Liu,

Wang,

Zhou

et al. 2024

Adv Healthcare Materials

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Parkinson's disease (PD) pathology speculates that neuromelanin (NM) and iron ions play a significant role in physiological and pathological conditions of PD. Because the difficult accessibility of NM has limited targeted research, synthetic melanin‐like nanoparticles have been used to instead. In this report, the eumelanin and pheomelanin‐like polydopamine (PDA) nanoparticles are prepared that can be used to simulate natural NM with or without chelating iron ion and studied the redox effects in vitro and in vivo on neuronal cells and PD. The synthetic pheomelanin‐like PDA nanoparticles have much stronger redox activity than eumelanin‐like PDA nanoparticles without or with iron ion. They can protect neurons by scavenging reactive oxygen species (ROS), while cause neuronal cell death and PD due to excessive binding of iron ions. This work provides new evidence for the relationship among two structural components of NM and iron in PD as well as displays the different effects on the roles of eumelanin and pheomelanin in redox activity under physiological or pathological conditions, which provide a new effective choice for cellular and animal models of PD and offer theoretical guidance for targeted treatment and mechanism research on PD.

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Gait dynamics in mouse models of Parkinson's disease and Huntington's disease

Cited by 149 publications

References 72 publications

Profiling changes in gait dynamics resulting from progressive 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced nigrostriatal lesioning

Profiling changes in gait dynamics resulting from progressive 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced nigrostriatal lesioning

Assessment of Motor Coordination and Balance in Mice Using the Rotarod, Elevated Bridge, and Footprint Tests

Protective and Damaging Mechanisms of Neuromelanin‐Like Nanoparticles and Iron in Parkinson's Disease

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