Gait in ageing and associated dementias; its relationship with cognition

Scherder, E.J.A.; Eggermont, L.H.P.; Swaab, Dick F.; Heuvelen, Marieke van; Kamsma, Y.P.T.; Greef, Mathieu de; Wijck, Ruud van; Mulder, Theo

doi:10.1016/j.neubiorev.2006.11.007

Cited by 205 publications

(172 citation statements)

References 119 publications

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“…The ability to maneuver in complex environments depends on intact attention/ executive function, and deficits in these areas represent risk factors for gait dysfunction and falls [3][4][5][6][7]. This may be especially true in patient populations with neurological disorders, in whom gait patterns may already be subtly altered [24]. Moreover, failure to appropriately identify patients who are at risk for falling likely results in a corresponding failure to implement necessary intervention strategies.…”

Section: Performance-based Measures Detect Falls Risk Associated Witmentioning

confidence: 99%

Performance-based assessment of falls risk in older veterans with executive dysfunction

et al. 2014

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Abstract-Falling is a serious hazard for older veterans that may lead to severe injury, loss of independence, and death. While the American Geriatrics Society (AGS) provides guidelines to screen individuals at risk for falls, the guidelines may be less successful with specific subgroups of patients. In a veteran sample, we examined whether the Timed Up and Go (TUG) test, including a modified version, the TUG-Cognition, effectively detected potential fallers whose risk was associated with cognitive deficits. Specifically, we sought to determine whether TUG tasks and AGS criteria were differentially associated with executive dysfunction, whether the TUG tasks identified potential fallers outside of those recognized by AGS criteria, and whether these tasks distinguished groups of fallers. Participants included 120 mostly male patients referred to the Memory Assessment Clinic because of cognitive impairment. TUG-Cognition scores were strongly associated with executive dysfunction and differed systematically between fallers grouped by number of falls. These findings suggest that the TUG-Cognition shows promise in identifying fallers whose risk is related to or compounded by cognitive impairment. Future research should study the predictive validity of these measures by following patients prospectively.

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Section: Performance-based Measures Detect Falls Risk Associated Witmentioning

confidence: 99%

Performance-based assessment of falls risk in older veterans with executive dysfunction

et al. 2014

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“…Eveneens gaat cognitieve achteruitgang in dementie vaak gepaard met motorische stoornissen, zoals balansproblemen (Scherder et al, 2007). Het is daarom van belang dat deze ouderen tijdens participatie aan een interventie bestaande uit lichamelijke activiteit gemonitord worden (Eggermont et al, 2006b).…”

Section: Alternatieve Vorm Van Bewegingunclassified

Lichamelijke activiteit, cognitie en dementie

Eggermont

Scherder²

2008

NEPR

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De vergrijzing van de populatie heeft geresulteerd in een grote toename van ouderen met dementie. De bestaande medicamenteuze therapieën voor dementie richten zich op de behandeling van symptomen en een zoektocht naar nieuwe behandelwijzen is volop gaande. Er is ook steeds meer aandacht voor activiteiten die het ontstaan en het verloop van dementie zouden kunnen vertragen. Eén zo'n vorm van activiteit die vooral de laatste paar jaar veel aandacht heeft gekregen, is lichamelijke activiteit.Lichamelijke activiteit, cognitie en dementie

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“…Gait is considered as an automatic and rhythmic motor activity whose the control depends in part on cognition Scherder et al 2007). In the past decade, a close relationship has been highlighted between gait control and specific cognitive domains Scherder et al 2007;Watson et al 2010).…”

Section: Introductionmentioning

confidence: 99%

“…In the past decade, a close relationship has been highlighted between gait control and specific cognitive domains Scherder et al 2007;Watson et al 2010). In particular, episodic memory and executive performances have been separately associated with gait performances among cognitively healthy individuals (CHI) and patients with mild cognitive impairment (MCI) and with dementia Scherder et al 2007;Watson et al 2010;Hausdorff et al 2005;Allali et al 2010;Beauchet et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Episodic memory and executive function impairments in non-demented older adults: which are the respective and combined effects on gait performances?

Beauchet

Launay

Fantino

et al. 2015

AGE

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Gait control depends in part on cognition. This study aims to examine the separate and combined effects of episodic memory and executive function impairments on the mean value and the coefficient of variation (CoV) of stride time among non-demented older community dwellers. Based on a cross-sectional design, 1458 older community dwellers without dementia (70.6 ± 4.9 years; 49.2 % female) were recruited and separated into cognitively healthy individuals (CHI) and individuals with cognitive impairment. A score ≤5/6 on the Short MiniMental State Examination defined episodic memory impairment. Impaired executive function was defined by errors on the clock-drawing test. Mean value and CoVof stride time were measured by the GAITRite® system. A total of 517 participants (35.5 %) had cognitive impairment in at least one cognitive domain. Participants with memory impairment (P = 0.006) and those with combined cognitive impairments (P < 0.001) had greater (i.e., worse gait performance) mean value of stride time (P = 0.006) compared to CHI. Participants with combined cognitive impairment had a greater CoV of stride time (i.e., worse gait performance) compared to CHI (P = 0.004) and to those with separate memory impairment (P = 0.037). Among participants with combined cognitive impairments, mean value and CoV of stride time had the highest effect size (respectively, effect size = 0.49 [95 % confidence interval (CI) 0.27;0.71] and effect size = 0.40 [95 %CI 0.18;0.62]). Participants with episodic memory or executive impairments had a greater mean value and CoV of stride time compared to those with no cognitive impairment. Combined episodic memory and executive impairments exceeded the sum of separate impairments on gait performances, suggesting a complex interplay going beyond a simple additive effect.

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Gait in ageing and associated dementias; its relationship with cognition

Cited by 205 publications

References 119 publications

Performance-based assessment of falls risk in older veterans with executive dysfunction

Performance-based assessment of falls risk in older veterans with executive dysfunction

Lichamelijke activiteit, cognitie en dementie

Episodic memory and executive function impairments in non-demented older adults: which are the respective and combined effects on gait performances?

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