Gait patterns of patients with inclusion body myositis

Bernhardt, Kathie A.; Oh, Terry H.; Kaufman, Kenton R.

doi:10.1016/j.gaitpost.2010.12.021

Cited by 10 publications

(14 citation statements)

References 22 publications

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“…Knee extension strength is also closely related to the 6MWD, which can be explained by the direct link between quadriceps strength and gait kinematics and kinetics [17]. This is also in accordance with the recent transversal study of Lowes et al on 85 patients where knee extensor strength correlated with performance measured by 2 and 6MWT [18].…”

Section: Discussionsupporting

confidence: 86%

Quadriceps strength is a sensitive marker of disease progression in sporadic inclusion body myositis

Allenbach¹,

Benveniste²,

Decostre³

et al. 2012

Neuromuscular Disorders

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Section: Discussionsupporting

confidence: 86%

Quadriceps strength is a sensitive marker of disease progression in sporadic inclusion body myositis

Allenbach¹,

Benveniste²,

Decostre³

et al. 2012

Neuromuscular Disorders

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“…Bernhardt and colleagues (19) reported on 9 subjects with s-IBM and quadriceps weakness. Using motion capture and force plates, these authors described the range of walking patterns that were present in their sample.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, rehabilitation specialists depend on kinematic gait parameters to inform clinical decisions associated with interventions and adaptive equipment. The promising initial findings of Bernhardt and colleagues (19) provide objective data and greatly enhance our understanding of gait in people with s-IBM. Despite the rigor of this group's motion capture methods used to characterize gait kinematics and kinetics, they were constrained by a modest sample size.…”

mentioning

confidence: 96%

“…Moreover, they stated that over 60% of their participants failed to maintain their independent ambulation status. Bernhardt and colleagues (19) identified a hyperextended knee during stance phase of gait in a proportion of their sample of individuals with s-IBM, while others displayed the typical knee flexion in loading response and neutral knee positioning during mid to late stance. All participants had normal peak knee flexion in early swing, with a few demonstrating excessive peak knee flexion during this portion of the gait cycle.…”

mentioning

confidence: 99%

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Lower Extremity Peak Force and Gait Kinematics in Individuals With Inclusion Body Myositis

Davenport

Benson²,

Baker

et al. 2014

Arthritis Care & Research

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Objective. To determine the relationship between peak isometric muscle force and temporal characteristics of gait in individuals with sporadic inclusion body myositis (s-IBM).Methods. An observational study of 42 individuals with s-IBM (12 women; mean ؎ SD age 61.8 ؎ 7.3 years and mean ؎ SD disease duration 8.9 ؎ 4.3 years) was conducted at a federal hospital. Peak isometric force measurements for lower extremity (LE) muscle groups were obtained using quantitative muscle testing. Temporal characteristics of gait during habitual and fast walking conditions were measured using a portable gait analysis system. Results. All observed muscle force values were significantly lower than predicted values (P < 0.001). During habitual walking, the subjects' gait speed and cadence were <83% of normative literature values. During fast walking, total gait cycle time was 133% of normal, while gait speed and cadence were 58% and 78% of normative literature values, respectively. Scaled LE peak muscle forces showed significant moderate correlations with temporal gait variables. Weaker subjects had greater limitations in gait speed and cadence compared with stronger subjects (P < 0.05). Peak isometric force of the knee flexors and ankle plantar flexors was significantly correlated with most temporal features of habitual gait. Conclusion. Muscle weakness associated with s-IBM disease activity may contribute to diminished gait kinematics. Temporal features of gait were not substantially influenced by knee extensor weakness alone, considering the knee flexors and ankle plantar flexors played a compensatory role in maintaining the walking ability of individuals with s-IBM.

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“…Recent studies have looked at the frequency and circumstances of falls (Hiscock et al, 2014), and have analysed the abnormal gait patterns in patients with IBM (Bernhardt et al, 2011, Davenport et al, 2015 finding that there is a good correlation between knee extensor strength and functional lower limb measures such as the 2-minute and 6-minute walk tests (Lowes et al, 2012, Alfano et al, 2014. A smaller group of patients present initially because of weakness of the long finger flexor muscles, which is usually more severe in the non-dominant hand, or bulbar weakness, with lower limb weakness occurring at a later stage.…”

Section: Patterns Of Muscle Involvementmentioning

confidence: 99%

Sporadic inclusion body myositis: A review of recent clinical advances and current approaches to diagnosis and treatment

Needham

Mastaglia

2016

Clinical Neurophysiology

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Sporadic inclusion body myositis is the most frequent acquired myopathy of middle and later life and is distinguished from other inflammatory myopathies by its selective pattern of muscle involvement and slowly progressive course, and by the combination of inflammatory and degenerative muscle pathology and multi-protein deposits in muscle tissue. This review summarises the findings of recent studies that provide a more complete picture of the clinical phenotype and natural history of the disease and its global prevalence and genetic predisposition. Current diagnostic criteria, including the role of electrophysiological and muscle imaging studies and the recently identified anti-5'-nucleotidase (anti-cN1A) antibody in diagnosis are also discussed as well as current trends in the treatment of the disease.

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Gait patterns of patients with inclusion body myositis

Cited by 10 publications

References 22 publications

Quadriceps strength is a sensitive marker of disease progression in sporadic inclusion body myositis

Quadriceps strength is a sensitive marker of disease progression in sporadic inclusion body myositis

Lower Extremity Peak Force and Gait Kinematics in Individuals With Inclusion Body Myositis

Sporadic inclusion body myositis: A review of recent clinical advances and current approaches to diagnosis and treatment

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