Gaitedness is associated with the <i><scp>DMRT</scp>3</i> ‘Gait keeper’ mutation in Morgan and American Curly horses

Jäderkvist, Kim; Kangas, Niina; Andersson, Leif; Lindgren, Gabriella

doi:10.1111/age.12228

Cited by 10 publications

(7 citation statements)

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“…DOCK8 is not only located on ECA23, the same chromosome as DMRT3 , but multiple studies have hypothesized some sort of commonality or overlap between DMRT -(1,2,3) gene effects and DOCK8 [ 22 , 82 , 84 ]. Despite the established association between DMRT3 and harness racing performance, additional research of DMRT3 in horses strongly suggest that the mutation is unlikely to be the single cause of gaiting ability [ 22 , 53 , 85 – 88 ]. Therefore, it is conceivable that DOCK8 also significantly contributes to gaiting ability, ultimately playing some role in a harness racing horse’s propensity to exhibit speed at trot or pace.…”

Section: Discussionmentioning

confidence: 99%

A genome-wide association study for harness racing success in the Norwegian-Swedish coldblooded trotter reveals genes for learning and energy metabolism

et al. 2018

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BackgroundAlthough harness racing is of high economic importance to the global equine industry, significant genomic resources have yet to be applied to mapping harness racing success. To identify genomic regions associated with harness racing success, the current study performs genome-wide association analyses with three racing performance traits in the Norwegian-Swedish Coldblooded Trotter using the 670 K Axiom Equine Genotyping Array.ResultsFollowing quality control, 613 horses and 359,635 SNPs were retained for further analysis. After strict Bonferroni correction, nine genome-wide significant SNPs were identified for career earnings. No genome-wide significant SNPs were identified for number of gallops or best km time. However, four suggestive genome-wide significant SNPs were identified for number of gallops, while 19 were identified for best km time. Multiple genes related to intelligence, energy metabolism, and immune function were identified as potential candidate genes for harness racing success.ConclusionsApart from the physiological requirements needed for a harness racing horse to be successful, the results of the current study also advocate learning ability and memory as important elements for harness racing success. Further exploration into the mental capacity required for a horse to achieve racing success is likely warranted.Electronic supplementary materialThe online version of this article (10.1186/s12863-018-0670-3) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

A genome-wide association study for harness racing success in the Norwegian-Swedish coldblooded trotter reveals genes for learning and energy metabolism

et al. 2018

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“…2016), Finn horses (Jäderkvist et al . 2015), Morgan and American Curly horses (Jäderkvist et al . 2014).…”

Section: Discussionmentioning

confidence: 99%

Genome-wide analysis reveals signatures of selection for gait traits in Yili horse

Liu

Fang

Meng

et al. 2018

Preprint

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10High quality gaits play an important role in many breeding programs, but the genes of gait 11 were limited at the moment. Here, we present an analysis of genomic selection signatures 12 in 53 individuals from two breeds, using genotype data from the Affymetrix Equine 670K 13 SNP genotyping array. The 11 selection regions of Yili horse were identified using an FST 14 statistic and XP-EHH calculated in 200-kb windows across the genome. In total, 50 genes 15 could be found in the 11 regions, and two candidate genes related to locomotory behavior 16 (CLN6, FZD4). The genome of Yili horse and Russian horse were shaped by natural and 17 artificial selection. Our results suggest that gait trait of Yili horse may related to two genes. 18 This is the first time when whole genome array data is utilized to study genomic regions 19 affecting gait in Yili horse breed.20

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“…Firstly, Jaderkvist, Andresson, et al. (2014, 2014) found a superiority of the AA genotype compared with CA and CC. Nevertheless, the significant difference at the age of 3 years disappeared mostly at 3–6 years of age and a non‐significant tendency of the CA genotype being superior to AA for earnings over 3 to 6 years of age appeared.…”

Section: Discussionmentioning

confidence: 99%

“…In these cases, the relationship with pace was sometimes exclusive with all pacer AA and all non‐pacer CC (Novoa‐Bravo et al., 2018). However, in most breeds, there were several AA horses that were unable to pace, even if none of the CC horse were able to pace (Amano et al., 2018; Fegraeus, Hirschberg, et al., 2017; Jaderkvist et al., 2015; Kristjansson et al., 2014) or all AA horses were able to pace, and some CC horses too ( Jaderkvist, Kangas, et al., 2014). However, there has been an established relationship between genotype at DMRT3 and the ability to pace (Han & Peñagaricano, 2016).…”

Section: Discussionmentioning

confidence: 99%

Genomic analysis of gaits and racing performance of the French trotter

Duluard

2020

J Animal Breeding Genetics

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The aim was to disentangle gait characteristics from other qualities needed for racing performances with a genomic analysis of French trotters (FT). A sample of 1,390 horses were recruited, from which 46% were genotyped with Illumina chip of 54,602 SNPs, 49% with Affymetrix chip of 670,806 SNPs and 586 had a completed questionnaire on trotting technique. Racing performances cover the period 1996 to 2018. There were 252,368 FT‐born; 96,617 qualified and 83,962 which participated in a race. After quality control, 377,611 SNPs were retained and imputed. Questionnaire described trotting technique over 13 questions which were summarized, after principal component analysis in 3 traits: pacer, heavy trot/gallop and other defects. GWAS and genomic evaluation were performed using single‐step approach. We found 25 QTL for racing performances and 9 for trotting technique. Only DMRT3 mutation was significant for both traits. To tend to pace avoid the defect at gallop and lead to a better early career for earnings, less percentage of disqualified races at all ages and more harness than under saddle career. This is the portrait of AA genotype at DMRT3. We found 5 other QTL, not linked to gait traits, which might improve selection of genetically independent performance traits of earnings per races and percentage of finished races. For only earnings at different ages and in under saddle or harness races, genomic evaluation remains the best way to predict performances.

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Gaitedness is associated with the DMRT3 ‘Gait keeper’ mutation in Morgan and American Curly horses

Cited by 10 publications

References 4 publications

A genome-wide association study for harness racing success in the Norwegian-Swedish coldblooded trotter reveals genes for learning and energy metabolism

A genome-wide association study for harness racing success in the Norwegian-Swedish coldblooded trotter reveals genes for learning and energy metabolism

Genome-wide analysis reveals signatures of selection for gait traits in Yili horse

Genomic analysis of gaits and racing performance of the French trotter

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