Galactin-3 and brain natriuretic peptide versus conventional echocardiography in the early detection of cirrhotic cardiomyopathy

Abbas, Wael A.; Ahmed, Sabah M.; Aal, Amal M Abdel; Mahmoud, Amal; Abdelmalek, Mohamed; Mekky, Mohamed A.; Abozaid, Mohamed A A; Ibrahim, Ahmed K.

doi:10.5152/tjg.2016.16100

Cited by 13 publications

(23 citation statements)

References 15 publications

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“…HCC is a reason for early qualification for OLTx, regardless of the MELD score. In a recent study, QTc (B) interval was found to be prolonged and longer in cirrhotic patients with ascites than in patients without ascites (472 vs. 531 ms, p<0.001) [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Pretransplant QT Interval: The Relationship with Severity and Etiology of Liver Disease and Prognostic Value After Liver Transplantation

et al. 2018

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BackgroundProlonged QT interval is an integral part of the definition of cirrhotic cardiomyopathy. The aim of this study was to analyze the relationship between QT corrected (QTc) and the etiology and the severity of liver disease in relation to the complications of cirrhosis in candidates for orthotropic liver transplantation (OLTx).Material/MethodsFrom 360 consecutive patients with end-stage liver disease (ESLD) consulted by a designated cardiologist, 160 patients underwent OLTx. The QTc was calculated according to 3 formulas in 151 ECG tracings with good quality. The severity of liver disease was assessed according to Child-Pugh classification and model for end-stage liver disease (MELD). This was a single-center study with register-based follow-up design.ResultsProlonged QTc over 440 ms was found in 51 subjects (33.8%), but none had prolonged QTc >500 ms. QTc corrected by Fridericia (F) formula was more suitable for patients with ESLD. We found no correlation between QTc interval and severity of liver disease. The QTc interval was higher in patients with alcoholic cirrhosis when compared to patients with viral hepatitis and ESLD of other etiologies. We observed a higher QTc interval in patients with gastroesophageal varices and encephalopathy. We did not notice any significant difference in the effect of the QTc interval on survival.ConclusionsQTc interval might be associated with etiology and complication of ESLD. The prolonged QT interval is not associated with higher all-cause mortality after OLTx.

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Section: Discussionmentioning

confidence: 99%

Pretransplant QT Interval: The Relationship with Severity and Etiology of Liver Disease and Prognostic Value After Liver Transplantation

et al. 2018

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“…Galectin-3, the most recent studied biomarker elevated in cirrhotic patients, has been associated with myocardial fibrosis and may correlates with severity of cirrhosis. This marker is proving to be more sensitive than BNP in the evaluation of diastolic dysfunction, though is less specific [16].…”

Section: Physiopathologymentioning

confidence: 99%

“…The most common ECG finding is QT interval prolongation, which may be observed in approximately 30-40% of cirrhotic patients, mainly Child-Pugh B or C, regardless cirrhosis etiology [19,16].…”

Section: Electrocardiogrammentioning

confidence: 99%

“…Natriuretic peptide are secreted by the cardiomyocytes in response to volume or pressure overload, or myocardial ischemia, to compensate RAAS effect in sodium and water balance [14,15]. BNP may be one of the most available biomarkers which allows an early recognition of cardiac involvement [16,17]. It's serum concentration is higher the more severe the liver and heart diseases [18].…”

Section: Laboratory Findingsmentioning

confidence: 99%

“…Meanwhile, the isovolumetric relaxation time, although highly sensitive, does not represent the LV filling and varies as the heart rate changes [16].…”

Section: Systolic Evaluationmentioning

confidence: 99%

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Cirrhotic cardiomyopathy: we already know. What comes next?

Mocarzel¹,

Bicca²,

Jarske³

et al. 2017

Dig Sys

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Cirrhotic Cardiomyopathy is a recently recognized condition consisting of myocardial dysfunction manifested in cirrhotic patients in the absence of previous cardiac disease. The underlying pathogenetic mechanisms includes a "miocardiotoxic" environment that leads to a blunted heart response to stress, whether physical or pharmacological. This condition is now better understood and can be diagnosed supported clinical, by laboratory electrocardiography and echocardiography criteria. Clinically, systolic incompetence is most evident when cirrhotic patients are placed under stress, whether physical or pharmacological. Despite of being well understood, there is a lack of knowledge to a proper practical application. Recent case reports have suggested that CCM must be treated early because it may be an triggering factor for cirrhosis complications. Studies are needed to identify potential treatments that alter the natural history of heart disease in cirrhotic patients, especially in the phases in which the patients are asymptomatic.

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