Galacto-fructo-oligosaccharide fortification of fermented non-dairy snack enhances calcium absorption in healthy adolescent girls

Sanwalka, Neha; Khadilkar, Anuradha; Chiplonkar, Shashi; Khadilkar, Vaman; Mughal, M Zulf

doi:10.3109/09637486.2011.627848

Cited by 12 publications

(5 citation statements)

References 44 publications

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“…Short-chain fatty acids produced during fermentation decrease intestinal pH thereby increasing calcium solubility and absorption in the distal colon (33). This physiologic change has been confirmed by a few human trials (16,34,35). However, there were no significant changes in serum calcium level in the present study.…”

Section: Discussionsupporting

confidence: 88%

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Effects of Fructo-Oligosaccharide Supplementation on Constipation in Elderly Continuous Ambulatory Peritoneal Dialysis Patients

et al. 2016

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♦ Background: Fructo-oligosaccharides (FOS) exhibit soluble-fiber properties that beneficially affect bowel function and relieve constipation. The effects of FOS supplementation on constipation and biochemical parameters were examined in elderly continuous ambulatory peritoneal dialysis (CAPD) patients. ♦ Methods: This randomized, double-blind, placebocontrolled, cross-over study was performed in elderly CAPD patients (5 males and 4 females) with chronic constipation. All subjects were randomly assigned to receive either 20 g FOS or placebo daily for 30 days. After a 14-day washout period, the patients were switched to the other substance for 1 more month. Before and after each treatment period, frequency of defecation, characteristics of feces, and colonic transit were evaluated. Biochemical parameters were also assessed. ♦ Results: Fructo-oligosaccharides significantly increased the frequency of defecation (10.5 ± 2.0 vs 6.2 ± 1.4 times per week, p < 0.005) and changed the feces' appearance from type 1 (nut-like) to type 4 (sausage-like). The colonic transit determined by geometric center (GC) was augmented after FOS supplementation (3.9 ± 0.3 vs 3.2 ± 0.4, p < 0.05). Fructo-oligosaccharides had no effects on biochemical parameters. Fructo-oligosaccharides caused mild discomforts which were well tolerated after dose adjustment. ♦ Conclusions: Fructo-oligosaccharide supplementation is effective, well tolerated, and can be an alternative to other laxatives in CAPD patients with constipation. Further studies are needed to better assess the biochemical effects of FOS in the chronic kidney disease population.

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Section: Discussionsupporting

confidence: 88%

“…Additionally, experimental studies have shown that FOS can reduce the levels of glucose, cholesterol, and serum urea nitrogen produced by bacterial growth and utilization (15). Change in colonic acidity also facilitates calcium absorption (9,16). Currently, no data are available for the use of FOS in CAPD patients with constipation.…”

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confidence: 99%

Effects of Fructo-Oligosaccharide Supplementation on Constipation in Elderly Continuous Ambulatory Peritoneal Dialysis Patients

et al. 2016

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“…This change was negatively correlated with fecal pH, suggesting a potential role of SCFA production. Sanwalka et al (81) showed that 1 dose of a FOS/GOS blend (8 g) with a meal increased Ca absorption in adolescent girls. Other RCT crossover studies have also shown increases in Ca absorption following FOS or inulin-enriched FOS supplementation in both male and female healthy adolescents (age 9–16 y) at doses ranging from 8 to 15 g/d, compared to maltodextrin or sucrose controls (82–85).…”

Section: Mineral Absorption and Balancementioning

confidence: 99%

Perspective: Physiologic Importance of Short-Chain Fatty Acids from Nondigestible Carbohydrate Fermentation

Alexander

Swanson

Fahey

et al. 2019

Advances in Nutrition

166

122

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In recent years, it has become increasingly obvious that dietary fiber or nondigestible carbohydrate (NDC) consumption is critical for maintaining optimal health and managing symptoms of metabolic disease. In accordance with this, the US FDA released its first official definition of dietary fiber in 2016 for regulation of Nutrition and Supplement Facts labels. Included in this definition is the requirement of an isolated or synthetic NDC to produce an accepted physiologic health benefit, such as improved laxation or reduced fasting cholesterol concentrations, upon consumption. Even though NDC fermentation and production of short-chain fatty acids elicit many physiologic effects, including serving as a source of energy for colonocytes, curbing glycemic response and satiety, promoting weight loss, enhancing mineral absorption, reducing systemic inflammation, and improving intestinal health, the process of fermentation is not considered a physiologic endpoint. Instead, expensive and laborious clinical trials must be conducted and an accepted physiologic benefit observed. In this review, we discuss the physiologic importance of NDC fermentation through extensive examination of clinical evidence and propose that the degree of fermentability of an NDC, rather than the endpoints of a clinical trial, may be appropriate for classifying it as a dietary fiber.

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“…Resta [48] confirmed this hypothesis by treating animal models with chronic inflammation-induced osteopenia and/or osteoporosis with commensal and probiotic bacteria. Further, evidence from a study in adolescents showed enhanced calcium absorption following supplementation with the prebiotic galacto-fructooligosaccharide [55]. Further, evidence from a study in adolescents showed enhanced calcium absorption following supplementation with the prebiotic galacto-fructooligosaccharide [55].…”

Section: Vitamin D and Calcium Absorptionmentioning

confidence: 99%

The role of gut microbiota in nutritional status

O’Connor

2013

Current Opinion in Clinical Nutrition and Metabolic Care

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New insights into the role of the gut microbiota and its holistic effects on the host are now emerging. High-throughput technologies allow for a greater insight into the role of the intestinal microbiota and the mechanisms by which it can contribute to overall nutritional status. Further, exploration of this evolving field of research will advance our understanding of how this complex ecosystem could advance the area of personalized nutrition in the future.

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Galacto-fructo-oligosaccharide fortification of fermented non-dairy snack enhances calcium absorption in healthy adolescent girls

Cited by 12 publications

References 44 publications

Effects of Fructo-Oligosaccharide Supplementation on Constipation in Elderly Continuous Ambulatory Peritoneal Dialysis Patients

Effects of Fructo-Oligosaccharide Supplementation on Constipation in Elderly Continuous Ambulatory Peritoneal Dialysis Patients

Perspective: Physiologic Importance of Short-Chain Fatty Acids from Nondigestible Carbohydrate Fermentation

The role of gut microbiota in nutritional status

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