2007
DOI: 10.1586/14737159.7.1.21
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Galactomannan antigen detection in the diagnosis of invasive aspergillosis

Abstract: Invasive aspergillosis is a serious and lethal infection among immunocompromised patients, with reported mortality rates as high as 74-92%. The high mortality is related to the severe immunosuppression experienced by these patients as well as the difficulties for physicians in arriving at a timely diagnosis. Definitive diagnostic procedures (tissue biopsy for histopathology and culture) are often precluded by severe cytopenias and coagulation abnormalities. The development of minimally invasive, nonculture dia… Show more

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Cited by 58 publications
(28 citation statements)
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“…The plasma galactomannan in this neutropenic model for IPA was significantly increased within the first three days, which is consistent with previous observations of the expression of galactomannan in IPA in neutropenic rabbit model systems and neutropenic patients with IPA [44]. Various PCR techniques for detecting Aspergillus species are being used on blood and BAL fluid [45,46] however none of the PCR-based tests are yet standardized or validated for reference laboratory use.…”
Section: Discussionsupporting
confidence: 86%
“…The plasma galactomannan in this neutropenic model for IPA was significantly increased within the first three days, which is consistent with previous observations of the expression of galactomannan in IPA in neutropenic rabbit model systems and neutropenic patients with IPA [44]. Various PCR techniques for detecting Aspergillus species are being used on blood and BAL fluid [45,46] however none of the PCR-based tests are yet standardized or validated for reference laboratory use.…”
Section: Discussionsupporting
confidence: 86%
“…The Platelia Aspergillus enzyme-linked immunoassay (EIA) detects a galactomannan antigen produced by several molds (5). However, studies to date have not included Histoplasma capsulatum.…”
mentioning
confidence: 99%
“…A biochemical basis for cross-reactivity between cryptococcal GalXM and Aspergillus GalM is not obvious (2,13). The structural dissimilarities among GalM, GalXM, and GXM suggest that the likelihood for shared antigenicity may be small (Fig.…”
mentioning
confidence: 99%