Galactomannan detection in Geotrichum capitatum invasive infections: report of 2 new cases and review of diagnostic options

Bonini, A; Capatti, Carlo; Parmeggiani, Maria; Gugliotta, Luigi; Micozzi, Alessandra; Gentile, Giuseppe; Capria, Saveria; Girmenia, Corrado

doi:10.1016/j.diagmicrobio.2008.08.008

Cited by 38 publications

(31 citation statements)

References 10 publications

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“…In fact, this is a case of breakthrough S. capitata infection, where the patient was treated empirically with caspofungin for more than 3 weeks. Consistent with our case, there are previous reports of breakthrough S. capitata infections in leukaemic patients on caspofungin/micafungin prophylaxis (Giacchino et al, 2006;Bonini et al, 2008;Chittick et al, 2009;Schuermans et al, 2011). All these cases succumbed to S. capitata infection (Schuermans et al, 2011).…”

Section: Discussionsupporting

confidence: 81%

Breakthrough disseminated Saprochaete capitata infection in a child with acute myeloid leukaemia receiving caspofungin therapy

et al. 2014

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Introduction: We present a fatal case of disseminated infection in a child with leukaemia, caused by Saprochaete capitata, an ascomycetous yeast.Case presentation: The aetiological role of disseminated infection by S. capitata in a child with relapsed acute myeloid leukaemia following bone-marrow transplantation was established by its repeated isolation from blood, tracheal secretion and urine samples. The identity of S. capitata was confirmed by phenotypic and molecular methods. The isolate showed reduced susceptibility to caspofungin. Conclusion:This report indicates that patients receiving echinocandin prophylaxis are at risk of breakthrough infections caused by S. capitata or other arthroconidial yeast species. To the best of our knowledge, this is the first well-documented case of S. capitata infection from the Middle East.Keywords: Breakthrough infection; echinocandins; fungaemia; Saprochaete capitata. IntroductionSaprochaete capitata, an anamorph of Magnusiomyces capitatus (de Hoog & Smith, 2004), previously known as Geotrichum capitatum or Blastoschizomyces capitatus, is a rarely reported cause of disseminated disease (Girmenia et al., 2005). It is known to colonize the respiratory and digestive tracts of humans and appears to have similar pathogenesis to other yeast species colonizing mucosal surfaces (Birrenbach et al., 2012). Most cases of S. capitata infection have occurred in patients with haematological malignancies and persistent neutropenia receiving chemotherapy (Fouassier et al., 1998;Martino et al., 2004;Girmenia et al., 2005;Miceli et al., 2011; Lafayette et al., 2011;Ö zkaya-Parlakay et al., 2012;García-Ruiz et al., 2013). Disseminated S. capitata, infection is associated with high mortality, thus underscoring the need for accurate identification, prior antifungal susceptibility testing and early initiation of specific therapy (Girmenia et al., 2005). Here, we describe a fatal case of breakthrough S. capitata infection in a child who was on empirical caspofungin therapy. Case reportAn 11-year-old Egyptian female, a known case of acute myeloid leukaemia since December 2009, underwent allogeneic bone-marrow transplantation in August 2011. She was admitted for a relapse and received chemotherapy with fludarabine, L-asparaginase and idarubicin. During chemotherapy, she developed fever, cough, renal impairment and bacteraemia with Stenotrophomonas maltophilia (susceptible to cotrimoxazole and colistin), and she was transferred to the paediatric intensive care unit (PICU) and started on colistin, caspofungin and metronidazole. During her PICU stay, she remained severely neutropenic (absolute neutrophil count ,100 mm 21 ) and experienced two more episodes of bacteraemia, one due to Staphylococcus epidermidis and the other due to Stenotrophomonas maltophilia from blood drawn through the Port-A-Cath. For these infections, she was treated with teicoplanin, colistin, meropenem, clarithromycin and cotrimoxazole. Caspofungin was added empirically in the treatment regimen. The Port-A-Cath was not change...

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Section: Discussionsupporting

confidence: 81%

Breakthrough disseminated Saprochaete capitata infection in a child with acute myeloid leukaemia receiving caspofungin therapy

et al. 2014

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“…En un medio sólido se identifican colonias blanco cremoso y en muestras aisladas produce hifas, psudohifas, blastoconidias y annelloconidias. Estudios in vitro e in vivo revelan que los antígenos de S. capitata pueden presentar reacciones cruzadas con el test de galactomannana de Aspergillus y también puede ser identificado mediante MALDI TOF MS 2,22,23 .…”

Section: Discussionunclassified

Rol de la cirugía en el manejo de la infección invasora por Saprochaete capitata

et al. 2017

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“…La greffe d'organes ne semble pas présenter un risque majeur puisque seulement 2 cas ont été décrits par Birrenbach et al [3] : L'expression clinique d'une géotrichose est peu spécifique avec une fièvre persistante sous antibiothérapie à large spectre [12,23]. La fièvre retrouvée chez la plupart des malades dans la littérature [3,4,6,9,[12][13][14]26,27] est apparue chez notre patient après 11 jours d'hospitalisation et a persisté malgré la mise sous antibiotique attirant l'attention vers un abcès profond ou une infection mycotique.…”

Section: Discussionunclassified

“…Jusque fin 2014, seulement une centaine de cas ont été décrits [4,15,17,21]. La plupart concerne des patients atteints de tumeurs malignes héma-tologiques ou recevant une chimiothérapie pour neutropénie persistante [3,4,6,[14][15][16][17]24].…”

Section: Introductionunclassified

Infection fongique disséminée à Magnusiomyces capitatus chez un patient transplanté hépatique

Yapo-Kouadio

Hasseine

Goubaux

et al. 2016

Journal de Mycologie Médicale / Journal of Medical Mycology

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Galactomannan detection in Geotrichum capitatum invasive infections: report of 2 new cases and review of diagnostic options

Cited by 38 publications

References 10 publications

Breakthrough disseminated Saprochaete capitata infection in a child with acute myeloid leukaemia receiving caspofungin therapy

Breakthrough disseminated Saprochaete capitata infection in a child with acute myeloid leukaemia receiving caspofungin therapy

Rol de la cirugía en el manejo de la infección invasora por Saprochaete capitata

Infection fongique disséminée à Magnusiomyces capitatus chez un patient transplanté hépatique

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