Galactooligosaccharides ameliorate dietary advanced glycation end product-induced intestinal barrier damage in C57BL/6 mice by modulation of the intestinal microbiome

Nie, Chenxi; Xie, Xiaoqing; Liu, Huicui; Yuan, Xiaojin; Ma, Qingyu; Tu, Aobai; Zhang, Min; Chen, Zhifei; Li, Juxiu

doi:10.1039/d2fo02959f

Cited by 3 publications

(3 citation statements)

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“…In particular, Sprague-Dawley rats exposed to a high AGE diet for 6, 12, or 18 weeks showed reduced α-diversity, altered crypts, goblet cell depletion, dysregulated expression of the colonic tight junctions zonulin-1 and occludin-1, and increased intestinal permeability, especially in the group fed a high AGE diet for 18 weeks [42]. In line with these findings, Nie et al reported that an AGE-enriched diet affected intestinal barrier integrity and microbial composition in C57BL/6 mice, while treatment with prebiotic galactooligosaccharides (GOS) limited these alterations by decreasing the frequency of Akkermansia muciniphila and increasing the number of goblet cells, tight junction expression, and short-chain fatty acid levels [43]. Furthermore, mice transplanted with fecal content from the AGE-treated group developed an altered mucus barrier, while those receiving feces from animals treated with GOS were protected [43].…”

Section: Agesmentioning

confidence: 77%

“…In line with these findings, Nie et al reported that an AGE-enriched diet affected intestinal barrier integrity and microbial composition in C57BL/6 mice, while treatment with prebiotic galactooligosaccharides (GOS) limited these alterations by decreasing the frequency of Akkermansia muciniphila and increasing the number of goblet cells, tight junction expression, and short-chain fatty acid levels [43]. Furthermore, mice transplanted with fecal content from the AGE-treated group developed an altered mucus barrier, while those receiving feces from animals treated with GOS were protected [43].…”

Section: Agesmentioning

confidence: 83%

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Impact of Western Diet and Ultra-Processed Food on the Intestinal Mucus Barrier

et al. 2023

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The intestinal epithelial barrier plays a key role in the absorption of nutrients and water, in the regulation of the interactions between luminal contents and the underlying immune cells, and in the defense against enteric pathogens. Additionally, the intestinal mucus layer provides further protection due to mucin secretion and maturation by goblet cells, thus representing a crucial player in maintaining intestinal homeostasis. However, environmental factors, such as dietary products, can disrupt this equilibrium, leading to the development of inflammatory intestinal disorders. In particular, ultra-processed food, which is broadly present in the Western diet and includes dietary components containing food additives and/or undergoing multiple industrial processes (such as dry heating cooking), was shown to negatively impact intestinal health. In this review, we summarize and discuss current knowledge on the impact of a Western diet and, in particular, ultra-processed food on the mucus barrier and goblet cell function, as well as potential therapeutic approaches to maintain and restore the mucus layer under pathological conditions.

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Section: Agesmentioning

confidence: 77%

Section: Agesmentioning

confidence: 83%

Impact of Western Diet and Ultra-Processed Food on the Intestinal Mucus Barrier

et al. 2023

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“…In a dose-responsive pattern, milk GOS have been found to modulate TEER, intensifying mucin gene expression and mucin abundance . Such GOS also elevate the expression of OCC, claudin-1, MUC2, TFF3 , RETNLB , and CHST5, thus enhancing the mucosal barrier function by directly stimulating intestinal goblet cells. , Moreover, goat milk-derived GOS have been observed to play a vital role in fortifying and restoring intestinal integrity after damage from DSS-induced colitis . A study identified that feeding neonatal NEC mice with yak milk GOS can effectively regulate the TLR-4/NF-kB inflammatory pathway and inhibit the expression of inflammatory factors (IL-6, IL-1, and TNF-α) to alleviate the occurrence of NEC .…”

Section: The Guardian Effect Of Milk Ingredients On the Gut Barriermentioning

confidence: 99%

Milk: A Natural Guardian for the Gut Barrier

Wang,

Gong,

Farid

et al. 2024

J. Agric. Food Chem.

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The gut barrier plays an important role in health maintenance by preventing the invasion of dietary pathogens and toxins. Disruption of the gut barrier can cause severe intestinal inflammation. As a natural source, milk is enriched with many active constituents that contribute to numerous beneficial functions, including immune regulation. These components collectively serve as a shield for the gut barrier, protecting against various threats such as biological, chemical, mechanical, and immunological threats. This comprehensive review delves into the active ingredients in milk, encompassing casein, α-lactalbumin, β-lactoglobulin, lactoferrin, the milk fat globular membrane, lactose, transforming growth factor, and glycopeptides. The primary focus is to elucidate their impact on the integrity and function of the gut barrier. Furthermore, the implications of different processing methods of dairy products on the gut barrier protection are discussed. In conclusion, this study aimed to underscore the vital role of milk and dairy products in sustaining gut barrier health, potentially contributing to broader perspectives in nutritional sciences and public health.

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