Galactosamine-Conjugating Zwitterionic Block Copolymer for Reduction-Responsive Release and Active Targeted Delivery of Doxorubicin to Hepatic Carcinoma Cells

Zhai, Jingming; Zhou, Baoyuan; An, Yanhui; Lu, Binzhong; Fan, Yonggang; Li, Junbo

doi:10.1155/2020/7863709

Cited by 4 publications

(1 citation statement)

References 40 publications

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“…Several studies have shown that liver cells can target liposomes by recognizing and taking up liposomes. For example, receptors such as the low-density lipoprotein receptor (LDLR) [90] and transferrin receptor (TfR) [178] can interact with liposomes and participate in their mechanism of targeting diseased areas of the liver.…”

Section: Active Targetingmentioning

confidence: 99%

Nanomaterials for Targeting Liver Disease: Research Progress and Future Perspectives

Wu¹,

Zhang²,

He³

et al. 2023

Nano Biomedicine and Engineering

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Liver disease is a significant global health issue that affects the liver and contributes to approximately 2 million deaths worldwide each year. Although treatment options including surgery and medication are available, effective treatment remains a challenge because of limitations of the traditional drug-delivery methods, such as uneven and nonspecific drug distribution, which lead to negative effects on healthy tissues and a reduction in drug bioavailability. Nanotechnology provides a promising solution for targeted drug delivery to the liver, which has unique anatomical and physiological structures that render it an ideal target for nanomedicine. Several categories of nanomaterials, including inorganic nanomaterials, polymer nanomaterials, and multifunctional nanoparticles (NPs), have been studied as potential agents for targeting this organ in the context of liver diseases. Using surface modification and functionalization, nanomaterials can be selectively targeted to liver tissue or hepatocytes, thus delivering drugs, and enhancing their efficacy while minimizing their side effects. Nanomaterials exhibit numerous benefits; however, their stability and toxicity pose potential risks to living organisms result in adverse effects, such as protein adsorption, and inflammation. Despite the challenges inherent to the development of nanomaterials, ongoing research and development have a great potential for the liver-targeted treatment of liver diseases through the use of nanotechnology. In this review, we first describe the nanomaterials used to target liver diseases, i.e., metallic NPs, ceramic nanomaterials, micelles, polysaccharides, liposomes, dendrimers, carbon nanotubes, and multifunctional NPs. Moreover, the mechanisms for nanomaterials target liver disease are discussed. Finally, this review discusses the current challenges and prospects for future research directions in this field.

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Section: Active Targetingmentioning

confidence: 99%

Nanomaterials for Targeting Liver Disease: Research Progress and Future Perspectives

Wu¹,

Zhang²,

He³

et al. 2023

Nano Biomedicine and Engineering

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Zwitterionic Nanogels and Microgels: An Overview on Their Synthesis and Applications

Saha

Ganguly

et al. 2021

Macromol. Rapid Commun.

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Zwitterionic polymers by virtue of their unique chemical and physical attributes have attracted researchers in recent years. The simultaneous presence of positive and negative charges in the same repeat unit renders them of various interesting properties such as superhydrophilicity, which has significantly broadened their scope for being used in different applications. Among polyzwitterions of different architectures, micro-and/or nano-gels have started receiving attention only until recently. These 3D cross-linked colloidal structures show peculiar characteristics in context to their solution properties, which are attributable either to the comonomers present or the presence of different electrolytes and biological specimens. In this review, a concise yet detailed account is provided of the different synthetic techniques and application domains of zwitterion-based micro-and/or nanogels that have been explored in recent years. Here, the focus is kept solely on the "polybetaines," which have garnered maximum research interest and remain the extensively studied polyzwitterions in literature. While their vast application potential in the biomedical sector is being detailed here, some other areas of scope such as using them as microreactors for the synthesis of metal nanoparticles or making smart membranes for water-treatment are discussed in this minireview as well.

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Encapsulation for general cancer treatment

Zolali¹,

Rashedi²,

Abdolahinia³

et al. 2023

Principles of Biomaterials Encapsulation : Volume Two

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Galactosamine-Conjugating Zwitterionic Block Copolymer for Reduction-Responsive Release and Active Targeted Delivery of Doxorubicin to Hepatic Carcinoma Cells

Cited by 4 publications

References 40 publications

Nanomaterials for Targeting Liver Disease: Research Progress and Future Perspectives

Nanomaterials for Targeting Liver Disease: Research Progress and Future Perspectives

Zwitterionic Nanogels and Microgels: An Overview on Their Synthesis and Applications

Encapsulation for general cancer treatment

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