Galactosylated iron oxide nanoparticles for enhancing oral bioavailability of ceftriaxone

Kawish, Muhammad; Jabri, Tooba; Elhissi, Abdelbary; Zahid, Hina; Iqbal, Kanwal; Rao, Komal; Gul, Jasra; Abdullah, Muhammad; Shah, Muhammad Raza

doi:10.1080/10837450.2020.1866602

Cited by 11 publications

(4 citation statements)

References 50 publications

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“…The size of the LEC−AMPB, MNP−LBA, MNP−LBA−CUR and MNP−LBA−AMPB are described in Table 1 . The increase in size of the MNP−LBA−CUR and MNP−LBA−AMPB is likely due to the drug incorporated into the cavity of MNP-LBA [ 26 ]. In the case of LEC−AMPB, the size was found to be 144 ± 16.2, suggesting its potential for biomedical applications [ 30 ].…”

Section: Resultsmentioning

confidence: 99%

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Nanocarrier Drug Conjugates Exhibit Potent Anti-Naegleria fowleri and Anti-Balamuthia mandrillaris Properties

et al. 2023

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Given the opportunity and access, pathogenic protists (Balamuthia mandrillaris and Naegleria fowleri) can produce fatal infections involving the central nervous system. In the absence of effective treatments, there is a need to either develop new antimicrobials or enhance the efficacy of existing compounds. Nanocarriers as drug delivery systems are gaining increasing attention in the treatment of parasitic infections. In this study, novel nanocarriers conjugated with amphotericin B and curcumin were evaluated for anti-amoebic efficacy against B. mandrillaris and N. fowleri. The results showed that nanocarrier conjugated amphotericin B exhibited enhanced cidal properties against both amoebae tested compared with the drug alone. Similarly, nanocarrier conjugated curcumin exhibited up to 75% cidal effects versus approx. 50% cidal effects for curcumin alone. Cytopathogenicity assays revealed that the pre-treatment of both parasites with nanoformulated-drugs reduced parasite-mediated host cellular death compared with the drugs alone. Importantly, the cytotoxic effects of amphotericin B on human cells alone were reduced when conjugated with nanocarriers. These are promising findings and further suggest the need to explore nanocarriers as a means to deliver medicine against parasitic infections.

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Section: Resultsmentioning

confidence: 99%

“…Next, the nanoparticles were diluted successively and analyzed at their respective wavelengths using a UV-VIS spectrophotometer [ 24 ]. Entrapment efficiency was determined using the equation below [ 26 ]:

…”

Section: Methodsmentioning

confidence: 99%

Nanocarrier Drug Conjugates Exhibit Potent Anti-Naegleria fowleri and Anti-Balamuthia mandrillaris Properties

et al. 2023

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“…Additionally, MRI indicated that liver signal intensity of SPIONdex could be detected after exposed for 24 h, which might be a candidate for MRI contrast agent [ 56 ]. Lactobionic acid (LBA) functionalized IONPs could enhance the release of ceftriaxone in albino rabbit model, and the plasma concentration of ceftriaxone was 14.46 ± 2.5 μg/mL, which was much higher than that in the control group [ 57 ]. The biological impact of SPION@PEG-COOH and SPION@PEG-NH 2 was assessed in mouse, which revealed there was no difference in mouse after intrapulmonary administration.…”

Section: Applications Of Ionps In Animal Modelsmentioning

confidence: 99%

Recent trends in preparation and biomedical applications of iron oxide nanoparticles

Meng,

Shi,

Zhu

et al. 2024

J Nanobiotechnol

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The iron oxide nanoparticles (IONPs), possessing both magnetic behavior and semiconductor property, have been extensively used in multifunctional biomedical fields due to their biocompatible, biodegradable and low toxicity, such as anticancer, antibacterial, cell labelling activities. Nevertheless, there are few IONPs in clinical use at present. Some IONPs approved for clinical use have been withdrawn due to insufficient understanding of its biomedical applications. Therefore, a systematic summary of IONPs’ preparation and biomedical applications is crucial for the next step of entering clinical practice from experimental stage. This review summarized the existing research in the past decade on the biological interaction of IONPs with animal/cells models, and their clinical applications in human. This review aims to provide cutting-edge knowledge involved with IONPs’ biological effects in vivo and in vitro, and improve their smarter design and application in biomedical research and clinic trials. Graphical Abstract

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“…Currently, ceftriaxone sodium is administered parenterally owing to its poor absorption, as it has two negatively charged carboxylate groups and is susceptible to enzymatic degradation in the gastrointestinal tract. To overcome this problem, several studies have been conducted to deliver ceftriaxone via the oral route using different approaches, such as coupling with absorption carriers (Jeon et al, 2013;Lee et al, 2005) [14,15], enteric coating (Maghrabia et al, 2019) [16], and encapsulation of particles of different polymeric matrices [17][18][19]. A major drawback of these approaches is the high preparation cost.…”

Section: Introductionmentioning

confidence: 99%

PBPK modelling of ceftriaxone Na-loaded starch-sodium alginate polymeric blend prepared by water-in-oil emulsification for oral delivery

Raza

Ilahi

Rashid

et al. 2022

Mater. Res. Express

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Ceftriaxone is a third-generation cephalosporin antibiotic effective against many bacterial infections. However, owing to its instability in the gastrointestinal tract (GIT), it is administered by injections, which is an unfavourable route of administration. Therefore, the aim of this study was to formulate ceftriaxone into biodegradable and thermally stable polymeric blend microparticles that are suitable for oral delivery. The drug-loaded microparticles were prepared by the water-in-oil (W/O) emulsion method and consisted of starch and sodium alginate (NaAlg) as a polymeric matrix and glutaraldehyde (GA) as a cross-linking agent. Characterization of these particles using scanning electron microscopy (SEM) showed that the particles were spherical in shape with a smooth surface. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) of these particles showed no drug-polymer interactions. The highest percentage yield of particles was obtained at 3% polymer concentration. The particle size increased slightly after drug loading. The drug loading and entrapment efficiency appeared to increase with increasing polymer concentration. In vitro drug release at pH 1.2 and pH 7.4, revealed that drug release was below 20% at the acidic pH, while at pH 7.4, drug release of up to 85% was observed. The release mechanism followed first-order and Fickian diffusion patterns. Plasma concentration-time profiles were simulated for subcontinental Asian populations using commercial PBPK software, and the results suggest that microencapsulation of ceftriaxone sodium in a polymeric blend could represent a promising approach for controlled oral delivery of the drug, with enhanced absorption and bioavailability of the drug.

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Galactosylated iron oxide nanoparticles for enhancing oral bioavailability of ceftriaxone

Cited by 11 publications

References 50 publications

Nanocarrier Drug Conjugates Exhibit Potent Anti-Naegleria fowleri and Anti-Balamuthia mandrillaris Properties

Nanocarrier Drug Conjugates Exhibit Potent Anti-Naegleria fowleri and Anti-Balamuthia mandrillaris Properties

Recent trends in preparation and biomedical applications of iron oxide nanoparticles

PBPK modelling of ceftriaxone Na-loaded starch-sodium alginate polymeric blend prepared by water-in-oil emulsification for oral delivery

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