Galangal—Roles in nutraceuticals and functional foods

Amalraj, Augustine; A.C., Karthik Varma; Jude, Shintu; Kuttappan, Sasikumar

doi:10.1016/b978-0-323-90794-1.00016-8

Cited by 6 publications

(3 citation statements)

References 61 publications

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“… 101 It also showed modest activities in the USA during Phase II, but a clinically considerable effect was observed in AD. Another plant-derived product, galanin (source—rhizomes of Alpinia officinarum ), has shown significant potential inhibition action against AChE, 102 but toxicity studies have not been conducted to date.…”

Section: Current Neurotherapeutics For Admentioning

confidence: 99%

Review of Pharmacotherapeutic Targets in Alzheimer’s Disease and Its Management Using Traditional Medicinal Plants

Tripathi,

Lodhi,

Rai

et al. 2024

DNND

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Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired daily functioning. While there is currently no cure for AD, several pharmacotherapeutic targets and management strategies have been explored. Additionally, traditional medicinal plants have gained attention for their potential role in AD management. Pharmacotherapeutic targets in AD include amyloid-beta (Aβ) aggregation, tau protein hyperphosphorylation, neuroinflammation, oxidative stress, and cholinergic dysfunction. Traditional medicinal plants, such as Ginkgo biloba, Huperzia serrata, Curcuma longa (turmeric), and Panax ginseng, have demonstrated the ability to modulate these targets through their bioactive compounds. Ginkgo biloba , for instance, contains flavonoids and terpenoids that exhibit neuroprotective effects by reducing Aβ deposition and enhancing cerebral blood flow. Huperzia serrata , a natural source of huperzine A, has acetylcholinesterase-inhibiting properties, thus improving cholinergic function. Curcuma longa , enriched with curcumin, exhibits anti-inflammatory and antioxidant effects, potentially mitigating neuroinflammation and oxidative stress. Panax ginseng’s ginsenosides have shown neuroprotective and anti-amyloidogenic properties. The investigation of traditional medicinal plants as a complementary approach to AD management offers several advantages, including a lower risk of adverse effects and potential multi-target interactions. Furthermore, the cultural knowledge and utilization of these plants provide a rich source of information for the development of new therapies. However, further research is necessary to elucidate the precise mechanisms of action, standardize preparations, and assess the safety and efficacy of these natural remedies. Integrating traditional medicinal-plant-based therapies with modern pharmacotherapies may hold the key to a more comprehensive and effective approach to AD treatment. This review aims to explore the pharmacotherapeutic targets in AD and assess the potential of traditional medicinal plants in its management.

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Section: Current Neurotherapeutics For Admentioning

confidence: 99%

Review of Pharmacotherapeutic Targets in Alzheimer’s Disease and Its Management Using Traditional Medicinal Plants

Tripathi,

Lodhi,

Rai

et al. 2024

DNND

View full text Add to dashboard Cite

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“…Plants use secondary metabolites including nicotine, rotenone, lianas, sabadala, pyrethrum, neem, and turmeric as natural defenses against insect pests [3]. Turmeric is derived from the root of Curcuma longa L., a perennial herb belonging to the Zingiberaceae family [4,5], and contains approximately 60-70% carbohydrates, 6-8% proteins, 5-10% fat, 3-7% minerals, and 6-13% moisture [5][6][7][8]. Within turmeric, there are more than 50 structurally related compounds known as curcuminoids, which make up approximately 3-5% of the total composition.…”

Section: Introductionmentioning

confidence: 99%

Disruptive Effects of Two Curcuminoids (Demethoxycurcumin and Bisdemethoxycurcumin) on the Larval Development of Drosophila melanogaster

Jeon,

Jeong,

Park

et al. 2023

Insects

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Juvenile hormones (JHs) play a central role in insect development, reproduction, and various physiological functions. Curcuminoids generally exhibit a wide range of biological activities, such as antioxidant, anti-inflammatory, antibacterial, and insecticidal, and they exhibit insect growth inhibitory effects. However, research on insecticidal properties of curcuminoids has been limited. Moreover, to the best of our knowledge, studies on JHs of insects and curcuminoids are lacking. Therefore, this study aimed to identify the substances that act as JH disruptors (JHDs) from edible plants. Demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC), two curcuminoids from the turmeric plant Curcuma longa L. inhibited the formation of a methoprene-tolerant (Met)–Taiman (Tai) heterodimer complex in Drosophila melanogaster, as shown through in vitro yeast two-hybrid assays. An artificial diet containing 1% (w/v) DMC or BDMC significantly reduced the number of D. melanogaster larvae in a concentration-dependent manner; larval development was disrupted, preventing the progression of larvae to pupal stages, resulting in an absence of adults. Building on the results obtained in this study on curcuminoids, researchers can use our study as a reference to develop eco-friendly pesticides.

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“…The natural and holistic properties of herbs and fruits, including pomegranate, strawberries, pineapple, kiwi, turmeric, ginger, amla, and mint, contribute significantly to their therapeutic potential. These substances are particularly effective in neutralizing oxidative stress, a key factor in exacerbating inflammation in IBD (12)(13)(14)(15)(16). Thus, incorporating these organic interventions into IBD management strategies presents a viable, complementary approach to conventional treatments, emphasizing their role in enhancing overall patient well-being and quality of life.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and Antioxidative Potential of Herbs and Fruits in the Management of Inflammatory Bowel Disease Beyond Medications

Hamza,

Zubair,

Habib

et al. 2023

JHRR

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Inflammatory Bowel Disease (IBD), a chronic inflammatory condition of the gastrointestinal tract, primarily encompasses ulcerative colitis and Crohn's disease. Characterized by recurring inflammation, IBD is marked by its unpredictability and complexity. Crohn's disease may impact any part of the digestive system, causing significant ulcerations, whereas ulcerative colitis is mainly restricted to the colon, leading to persistent damage and ulcers. The intermittent nature of IBD, alternating between remission and active flare-ups, presents continuous challenges in patient care and treatment. Its etiology is multifaceted, involving a combination of genetic susceptibility, environmental triggers, and immune system malfunctions. Symptomatically diverse, IBD can manifest as abdominal discomfort, diarrhea, weight loss, and fatigue, complicating the establishment of uniform treatment protocols. Traditional pharmacological treatments often offer limited relief and may introduce side effects, necessitating frequent adjustments in therapy. This disease profoundly impacts not only the physical well-being of individuals but also their overall quality of life, calling for a comprehensive and individualized management approach. This review delves into the potential of herbs and fruits in IBD management, examining their proximate composition and the roles their anti-inflammatory and antioxidant properties play in enhancing gut health.

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Galangal—Roles in nutraceuticals and functional foods

Cited by 6 publications

References 61 publications

Review of Pharmacotherapeutic Targets in Alzheimer’s Disease and Its Management Using Traditional Medicinal Plants

Review of Pharmacotherapeutic Targets in Alzheimer’s Disease and Its Management Using Traditional Medicinal Plants

Disruptive Effects of Two Curcuminoids (Demethoxycurcumin and Bisdemethoxycurcumin) on the Larval Development of Drosophila melanogaster

Anti-inflammatory and Antioxidative Potential of Herbs and Fruits in the Management of Inflammatory Bowel Disease Beyond Medications

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