Galangin loaded galactosylated pluronic F68 polymeric micelles for liver targeting

Patil, Sharvil; Ujalambkar, Vinayak; Rathore, Atul; Rojatkar, Supada R.; Pokharkar, Varsha

doi:10.1016/j.biopha.2019.108691

Cited by 51 publications

(22 citation statements)

References 29 publications

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“…The reported CMC values of F68 range from 0.4-1 mM. [32][33][34] The CMC of F68 is found to be slightly higher than that for F127 in aqueous solution. F68 contains fewer hydrophobic, PPO units in comparison to F127.…”

Section: Determination Of Critical Micelle Concentration Of F127 and F68mentioning

confidence: 99%

Self-assemblies of pluronic micelles in partitioning of anticancer drugs and effectiveness of this system towards target protein

Prasanthan

Kishore

2021

RSC Adv.

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Section: Determination Of Critical Micelle Concentration Of F127 and F68mentioning

confidence: 99%

Self-assemblies of pluronic micelles in partitioning of anticancer drugs and effectiveness of this system towards target protein

Prasanthan

Kishore

2021

RSC Adv.

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“…CMC is an important parameter for evaluating the aggregation capability of copolymer in aqueous condition, which influences the self-assembly ability and structural stability of copolymer micelles both in vitro and in vivo (Patil et al, 2019;Puig-Rigall et al, 2021). In this section, the CMC value of HA-VES was measured.…”

Section: Characterization Of Different Formulationsmentioning

confidence: 99%

“…Therefore, the introduction of other copolymers and the construction of mixed micelles is a promising strategy for enhancing the stability. Pluronics as triblock copolymers with repeated a PEO-PPO-PEO sequence has attracted great attention for NDDS due to its biocompatibility and biodegradability, and Pluronic F68 has been widely used for construction of temperature-sensitive gels (Huang et al, 2008;Al Khateb et al, 2016;Powell et al, 2017;Patil et al, 2019;Wang et al, 2019). The introduction of F68 in copolymer micelles is a promising strategy for enhancing the stability of the copolymer micelle.…”

Section: Introductionmentioning

confidence: 99%

Rational Design of Hyaluronic Acid-Based Copolymer-Mixed Micelle in Combination PD-L1 Immune Checkpoint Blockade for Enhanced Chemo-Immunotherapy of Melanoma

Zhou

Dong

Song

et al. 2021

Front. Bioeng. Biotechnol.

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The application of combinational therapy breaks the limitation of monotherapy and achieves better clinical benefit for tumor therapy. Herein, a hyaluronic acid/Pluronic F68-based copolymer-mixed micelle was constructed for targeted delivery of chemotherapeutical agent docetaxel (PHDM) in combination with programmed cell death ligand-1(PD-L1) antibody. When PHDM+anti-PDL1 was injected into the blood system, PHDM could accumulate into tumor sites and target tumor cells via CD44-mediated endocytosis and possess tumor chemotherapy. While anti-PDL1 could target PD-L1 protein expressed on surface of tumor cells to the immune checkpoint blockade characteristic for tumor immunotherapy. This strategy could not only directly kill tumor cells but also improve CD8+ T cell level and facilitate effector cytokines release. In conclusion, the rational-designed PHDM+anti-PDL1 therapy strategy creates a new way for tumor immune-chemotherapy.

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“…The FTIR spectra of DLX and lyophilized optimum in situ cubo-gel are shown in Figure 5. The FTIR spectra of GMO, 52,53 GTP, 50,51 PF127, 52,54 and F68 55 are obtained from previous studies found in the literature. The DLX spectrum showed distinct peaks at 1577.77 (aromatic alkenes), 1462.04 (thiophene ring), and 1234.44 (carbonyl group).…”

Section: Ftirmentioning

confidence: 99%

<p>Brain Targeting of Duloxetine HCL via Intranasal Delivery of Loaded Cubosomal Gel: In vitro Characterization, ex vivo Permeation, and in vivo Biodistribution Studies</p>

Elsenosy¹,

Abdelbary²,

Elshafeey³

et al. 2020

IJN

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Purpose: Duloxetine (DLX) is dual serotonin and norepinephrine reuptake inhibitor suffering from limited bioavailability (≈ 40%) due to extensive hepatic metabolism. This work aims to formulate and evaluate DLX intranasal thermoreversible cubosomal gels to enhance its bioavailability and ensure efficient brain targeting. Materials and Methods: Cubo-gels were prepared by 3 3 central composite design with three independent factors, lipid ratio (glycerol monooleate: glycerol tripalmitate), Pluronic F127%, and Pluronic F68%. The prepared formulations were evaluated for their particle size (PS), gelling temperature (GT), entrapment efficiency (EE%), and in vitro release. The cubogel with the highest desirability (0.88) was chosen as the optimized formulation. DLX cubogel was evaluated using differential scanning calorimetry, Fourier-transform infrared spectroscopy, X-ray powder diffraction, and transmission electron microscopy. Cytotoxicity study, ex vivo permeation study and in vivo bio-distribution study were conducted to evaluate the safety and efficacy of brain targeting. Results: The optimum cubo-gel was composed of 3.76 lipid ratio, 20% w/v PF127, and 5% w/v PF68. It had PS of 265.13 ± 9.85 nm, GT of 32 ± 0.05°C, EE% of 98.13 ± 0.50%, and showed controlled release behavior where 33% DLX was released within 6 hrs. The plain in situ cubo-gel had a significantly higher IC 50 compared to DLX solution and DLX-loaded in situ cubo-gel. The ex vivo permeation study showed 1.27 enhancement in the drug permeation from DLX in situ cubo-gel. According to the in vivo bio-distribution study in plasma and brain, the intranasal DLX in situ cubo-gel showed a 1.96 fold improvement in brain bioavailability compared to the intranasal solution. Its BTE% and DTP% were 137.77 and 10.5, respectively, indicating efficient brain targeting after intranasal administration. Conclusion: Accordingly, intranasal DLX in situ cubo-gel can be considered as an innovative nano-carrier delivery system for bioavailability enhancement and efficient brain targeting of DLX to maximize its effect.

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Galangin loaded galactosylated pluronic F68 polymeric micelles for liver targeting

Cited by 51 publications

References 29 publications

Self-assemblies of pluronic micelles in partitioning of anticancer drugs and effectiveness of this system towards target protein

Self-assemblies of pluronic micelles in partitioning of anticancer drugs and effectiveness of this system towards target protein

Rational Design of Hyaluronic Acid-Based Copolymer-Mixed Micelle in Combination PD-L1 Immune Checkpoint Blockade for Enhanced Chemo-Immunotherapy of Melanoma

<p>Brain Targeting of Duloxetine HCL via Intranasal Delivery of Loaded Cubosomal Gel: In vitro Characterization, ex vivo Permeation, and in vivo Biodistribution Studies</p>

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