Galanin(1-15) Potentiates the Antidepressant-like Effects Induced by Escitalopram in a Rat Model of Depression

García-Durán, Laura; Flores-Burgess, Antonio; Cantero-García, Noelia; Puigcerver, Araceli; Narváez, José Ángel; Fuxé, Kjell; Santín, Luis J.; Millón, Carmelo; Dı́az-Cabiale, Zaida

doi:10.3390/ijms221910848

Cited by 10 publications

(10 citation statements)

References 53 publications

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“…In both tests, the combination of GAL(1-15) and ESC induced a substantial reduction in the number of reinforcements, suggesting that GAL(1-15) + ESC caused a loss of motivational behaviour induced by an artificial reinforcer. This effect in the loss of motivational behaviour is powerful since it is induced with the coadministration of threshold doses of GAL (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) and ESC [24,29].…”

Section: Discussionmentioning

confidence: 99%

“…The fact that the GAL(1–15) and ESC combination can modulate the reward system with both natural and artificial reinforcers such as alcohol, in addition to improving depressive symptoms in an animal model of depression such as OBX rats [ 29 ] opens up the possibility to use this combination as augmentation therapy in the depression and AUD comorbidity.…”

Section: Discussionmentioning

confidence: 99%

“…The doses of GAL (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) employed in the rewarding tests and the anxiety and depressionrelated tests were based on previous studies [22,24,29]. The doses of GAL (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) in the ethanol self-administration test were based on a GAL(1-15) dose-response curve in this test (data not shown).…”

Section: Methodsmentioning

confidence: 99%

“…Depressive behaviour was assessed using the TST, performed as described previously [ 23 , 29 ]. Briefly, rats were hung upside down using an adhesive tape to fix the tail to a rope through an eyebolt at 60 cm.…”

Section: Methodsmentioning

confidence: 99%

“…This GAL(1–15) effect was also observed in an olfactory bulbectomized rat (OBX) model of depression [ 27 , 28 ]. GAL(1–15) also enhanced the antidepressant–like effects induced by ESC in OBX rats, and 5HT1AR significantly participates in the GAL(1–15)/ESC interaction [ 29 ]. Two functional networks were involved in the effects; one of them includes the lateral (LHb) and medial (mHB) habenula, dorsal raphe (DR) and ventral tegmental area (VTA), and the other includes the dentate gyrus (DG) and prefrontal cortex (PFC) [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

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The Combination of Galanin (1–15) and Escitalopram in Rats Suggests a New Strategy for Alcohol Use Disorder Comorbidity with Depression

et al. 2022

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Alcohol use disorder (AUD) is highly prevalent, and over 50% of AUD patients also suffer major depressive disorders. Selective 5–HT reuptake inhibitors (SSRIs) can reduce rodent ethanol drinking but exert modest clinical efficacy in alcoholic individuals. Finding new pharmacological strategies that could modulate alcohol consumption and depression is necessary. We have analyzed the effect of Galanin(1–15) [GAL(1–15)] on escitalopram (ESC)–mediated effect in alcohol consumption using the alcohol self–administration test, the nuclei involved in the effect, and whether GAL(1–15 + ESC modulated the response in despair or anxiety tests in animals under chronic alcohol intake. GAL(1–15) + ESC combination substantially reduced alcohol intake in the alcohol self–administration test and, moreover, enhanced the reduction of reward capacity of ESC on different reinforcers such as sucrose or saccharine. GAL(1–15) + ESC coadministration significantly decreases the number of c–Fos–IR TH cell bodies in the VTA, and PCA analysis suggests that one functional network, including VTA, RMTg and DR, is involved in these effects. Significantly in rats with chronic alcohol consumption, GAL(1–15) reversed adverse ESC–mediated effects in the depression–related behavioural test and forced swimming test. The results open up the possibility of using GAL(1–15) in combination with the SSRI Escitalopram as a novel strategy in AUD comorbidity with depression.

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