Galanin — a novel biologically active peptide from porcine intestine

Tatemoto, Kazuhiko; Rökaeus, Åke; Jörnvall, Hans; McDonald, Thomas J.; Mutt, Viktor

doi:10.1016/0014-5793(83)80033-7

Cited by 1,455 publications

(570 citation statements)

References 19 publications

Supporting

Mentioning

554

Contrasting

Unclassified

Order By: Relevance

“…In this context, the neuropeptide galanin (Tatemoto et al, 1983) is of particular interest, since it coexists with NA in the locus coeruleus (LC) and with 5-HT in the dorsal raphe (DR) nucleus (Melander et al, 1986;Xu and Hökfelt, 1997;Xu et al, 1998b). Electrophysiological, behavioral, and neurochemical studies have shown that galanin exerts modulatory (mainly inhibitory) effects on both the noradrenergic and serotonergic systems (Seutin et al, 1989;Sevcik et al, 1993;Pieribone et al, 1995;Xu et al, 1998c;Razani et al, 2001;Kehr et al, 2002;see Ö gren et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Differential Role of Galanin Receptors in the Regulation of Depression-Like Behavior and Monoamine/Stress-Related Genes at the Cell Body Level

Kuteeva

Wardi

Lundström

et al. 2008

Neuropsychopharmacol

View full text Add to dashboard Cite

The present study on rat examined the role of galanin receptor subtypes in regulation of depression-like behavior as well as potential molecular mechanisms involved in the locus coeruleus (LC) and dorsal raphe (DR). The effect of intracerebroventricular (i.c.v.) infusion of galanin or galanin receptor GalR1-and GalR2-selective ligands was studied in the forced swim test, followed by quantitative in situ hybridization studies. Naive control, non-treated (swim control), saline-and fluoxetine-treated rats were used as controls in the behavioral and in situ hybridization studies. Subchronic treatment with fluoxetine reduced immobility and climbing time. Intracerebroventricular infusion of galanin, the GalR1 agonist M617 or the GalR2 antagonist M871 increased, while the GalR2(R3) agonist AR-M1896 decreased, immobility time compared to the aCSF-treated animals. Galanin also decreased the time of climbing. Galanin mRNA levels were upregulated by the combination of injection + swim stress in the saline-and the fluoxetine-treated groups in the LC, but not in the DR. Also tyrosine hydroxylase levels in the LC were increased following injection + swim stress in the saline-and fluoxetine-treated rats. Tryptophan hydroxylase 2 and serotonin transporter mRNAs were not significantly affected by any treatment. 5-HT 1A mRNA levels were downregulated following i.c.v. galanin, M617 or AR-M1896 infusion. These results indicate a differential role of galanin receptor subtypes in depression-like behavior in rodents: GalR1 subtype may mediate 'prodepressive' and GalR2 'antidepressant' effects of galanin. Galanin has a role in behavioral adaptation to stressful events involving changes of molecules important for noradrenaline and/or serotonin transmission.

show abstract

Section: Introductionmentioning

confidence: 99%

Differential Role of Galanin Receptors in the Regulation of Depression-Like Behavior and Monoamine/Stress-Related Genes at the Cell Body Level

Kuteeva

Wardi

Lundström

et al. 2008

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…In mammals, acute injection of galanin or active fragments such as galanin (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16), into the PVN, lateral and ventromedial hypothalamic nuclei, and the central nucleus of the amygdala, significantly increases food intake and produces rapid increases in the feeding response and total caloric intake [4,5,11,12] . The effects of galanin on feeding be-…”

Section: Effects Of Galanin On Food Intake and Energy Expenditurementioning

confidence: 99%

“…Numerous studies have revealed that the activation of neurons containing galanin in the paraventricular nucleus (PVN) of the hypothalamus augment food intake and body weight [4,5] . Galanin, a 29-amino-acid neuropeptide, is mainly distributed in central and peripheral nervous systems [6] . Currently, it is known that the galanin receptor subtypes include GalR1, GalR2 and GalR3, all of which are G protein-coupled receptors [7] and are distributed in the hypothalamus, amygdala, hippocampus, thalamus, brainstem, spinal cord and dorsal root ganglia [7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

Central nervous system regulation of food intake and energy expenditure: role of galanin-mediated feeding behavior

Fang

et al. 2011

Neurosci. Bull.

View full text Add to dashboard Cite

Abstract:Galanin is a neuropeptide widely expressed in the brain. It is implicated in energy expenditure, feeding, and the regulation of body weight. Numerous studies have revealed that galanin regulates food intake via galanin receptors, 5-HT 1A receptor and adrenergic α-2 receptor. In this review, we summarize recent findings that reveal the essential role of galanin in increasing food intake as well as body weight and that identify the individual galanin receptor subtypes involved in the brain's modulation of food intake and energy expenditure, to provide a theoretical basis for further studies of different aspects of galanin action.

show abstract

“…Galanin is a 29 amino acid neuropeptide (Tatemoto, K., Rokaeus, A., et al 1983) which is widely distributed throughout the peripheral and central nervous system, and is involved in a broad range of brain functions such as food intake (Kalra, S.P. and Horvath, T.L.…”

Section: Introductionmentioning

confidence: 99%

Galanin expressed in the excitatory fibers attenuates synaptic strength and generalized seizures in the piriform cortex of mice

Schlifke

Kuteeva

Hökfelt

et al. 2006

Experimental Neurology

View full text Add to dashboard Cite

Galanin — a novel biologically active peptide from porcine intestine

Cited by 1,455 publications

References 19 publications

Differential Role of Galanin Receptors in the Regulation of Depression-Like Behavior and Monoamine/Stress-Related Genes at the Cell Body Level

Differential Role of Galanin Receptors in the Regulation of Depression-Like Behavior and Monoamine/Stress-Related Genes at the Cell Body Level

Central nervous system regulation of food intake and energy expenditure: role of galanin-mediated feeding behavior

Galanin expressed in the excitatory fibers attenuates synaptic strength and generalized seizures in the piriform cortex of mice

Contact Info

Product

Resources

About