2010
DOI: 10.1007/978-3-0346-0228-0_12
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Galanin, Galanin Receptor Subtypes and Depression-Like Behaviour

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Cited by 71 publications
(83 citation statements)
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“…This observation is in line with evidence for a prodepressive effect of GAL (34,35). In accordance with these observations, mice overexpressing GAL were shown to display increased immobility in the FST, indicative of enhanced depression-like behavior (7).…”
Section: Discussionsupporting
confidence: 69%
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“…This observation is in line with evidence for a prodepressive effect of GAL (34,35). In accordance with these observations, mice overexpressing GAL were shown to display increased immobility in the FST, indicative of enhanced depression-like behavior (7).…”
Section: Discussionsupporting
confidence: 69%
“…However, similar to the complex effects of GAL on anxiety, recent studies indicate an antidepressant-like effect of GAL as well (34). Thus, i.p.…”
Section: Discussionmentioning
confidence: 80%
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“…However, it is important to note that recent studies demonstrated that in humans GALR3 receptors are more prevalent in the brainstem compared with GALR1, whereas GALR1 is widely expressed in the human forebrain (26). In the 5-HT neuron-rich rat dorsal raphe nucleus/ periaqueductal gray, Lu et al (39) have suggested that mood is controlled through a balance between signaling via prodepressive GALR1/3 (71, 72) and antidepressive GALR2 receptors (38,39). In the ventral tegmental area galanin inhibits dopamine neurons, inducing depression-like behavior (40).…”
Section: Discussionmentioning
confidence: 99%
“…Galanin exerts its action via three cloned receptors, GALR1, GALR2, and GALR3 (33, 34) with a broad distribution in rat (35) and primate brain (26,36). Animal behavioral studies (31,32,(37)(38)(39)(40)(41)) and a single study in humans (42) suggest that galanin has a role in stress, depressionlike behavior, and anxiety. In addition, there is indication from Significance Early and recent environmental stressors, such as maltreatment in childhood, or stressful life events in adulthood, are important risk factors for depression.…”
mentioning
confidence: 99%