Galanin modulating effect on restraint stress-induced short- and long-term behavioral changes in Wistar rats

Nucleus accumbens lentiviral-mediated gain of function of the oxytocin receptor regulates anxiety- and ethanol-related behaviors in adult mice

“…These tests are commonly used in rodent models of anxiety and were susceptible to the anxiolytic effects of oxytocin in previous studies [56,57]. In the current experiment, lentiviral-mediated increases in NAcc OxtR decreased levels of anxiety in the EPM, OF and MBT tests.…”

Regulation of neurological and neuropsychiatric phenotypes by locus coeruleus-derived galanin

“…Most of these investigations tested the prediction that galanin would acutely diminish stress and anxiety-related behaviors and are based on a hypothetical mechanism involving acute reductions in noradrenergic LC activity. Centrally administered galanin or the nonselective agonist galnon indeed exerts anxiolytic actions in rats or mice in the conflict test (Bing et al, 1993) and elevated zero maze (Rajarao et al, 2007), and peripherally administered galanin is reported to produce lasting anxiolytic-like effects on open field exploration in rats (Klenerova et al, 2011). By contrast, centrally administered galanin fails to alter behavior in mice in the elevated plus maze, light-dark exploration, and novel open field tests (Karlsson et al, 2005; Karlsson and Holmes, 2006).…”

Activation of presynaptic oxytocin receptors enhances glutamate release in the ventral hippocampus of prenatally restraint stressed rats

“…To activate oxytocin receptors we used carbetocin, a potent and selective oxytocin receptor agonist, which has longer elimination half-life than oxytocin (Cort et al, 1981), and is clinically used for the control of postpartum bleeding (Engstrøm et al, 1998). Carbetocin can cross the blood-brain barrier (Dvorská et al, 1992), and is known to affect animal behavior after peripheral administration (Klenerova et al, 2009(Klenerova et al, , 2010Chaviaras et al, 2010;Mak et al, 2012).…”