Galectin-1-driven upregulation of SDF-1 in pancreatic stellate cells promotes pancreatic cancer metastasis

Dong, Qian; Lu, Zipeng; Xu, Qingcheng; Wu, Pengfei; Tian, Lei; Zhao, Liangtao; Cai, Baobao; Yin, Jie; Wu, Yang; Staveley-O’Carroll, Kevin F.; Jiang, Kuirong; Miao, Yi; Li, Guangfu

doi:10.1016/j.canlet.2017.03.024

Cited by 53 publications

(35 citation statements)

References 46 publications

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“…The dynamic crosstalk between PSCs and cancer cells as well as PSCs' role in generating desmoplasia have already been well established [6][7][8]. Emerging literature has now unravelled new biological processes related to PSC induced tumor progression, survival and therapeutic escape mechanisms in PDAC [9][10][11][12]. These new insights will, in the near future, fuel the development of therapeutics against PDAC and support for the better clinical outcomes.…”

Section: Pancreatic Ductal Adenocarcinomamentioning

confidence: 92%

“…Furthermore, EMT has also been related to chemoresistance, another factor by which PSCs contribute to the PDAC drug resistance [14]. More recently, galectin-1-induced upregulation of stromal derived factor (SDF-1), also known as C-X-C motif chemokine (CXCL12) in aPSCs was shown to promote pancreatic cancer metastasis [9]. Next to the ability of PSCs to increase the metastatic potential of PDAC cancer cells, PDAC cells secrete PDGF, which is a chemotactic factor that potentially regulates the role of PSCs in the metastatic…”

Section: Role Of Apscs In Pdac Metabolic Reprogrammingmentioning

confidence: 99%

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Targeting Pancreatic Stellate Cells in Cancer

2019

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Section: Pancreatic Ductal Adenocarcinomamentioning

confidence: 92%

Section: Role Of Apscs In Pdac Metabolic Reprogrammingmentioning

confidence: 99%

Targeting Pancreatic Stellate Cells in Cancer

2019

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“…Mechanistically, microarray studies have suggested candidate genes and pathways that are potentially involved in these effects on growth and metastasis, such as STAT and Hh signaling, IL1A, MMP-1, and ANK3 [62,65]. Moreover, increased metastasis formation could also be due to the axis SDF1-CXCR4 [72].…”

Section: Galectin-1 and Its Role In Pancreatic Cancermentioning

confidence: 99%

The Galectin Family as Molecular Targets: Hopes for Defeating Pancreatic Cancer

Manero-Rupérez

Martínez-Bosch

Barranco

et al. 2020

Cells

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Galectins are a family of proteins that bind β-galactose residues through a highly conserved carbohydrate recognition domain. They regulate several important biological functions, including cell proliferation, adhesion, migration, and invasion, and play critical roles during embryonic development and cell differentiation. In adults, different galectin members are expressed depending on the tissue type and can be altered during pathological processes. Numerous reports have shown the involvement of galectins in diseases, mostly inflammation and cancer. Here, we review the state-of-the-art of the role that different galectin family members play in pancreatic cancer. This tumor is predicted to become the second leading cause of cancer-related deaths in the next decade as there is still no effective treatment nor accurate diagnosis for it. We also discuss the possible translation of recent results about galectin expression and functions in pancreatic cancer into clinical interventions (i.e., diagnosis, prediction of prognosis and/or therapy) for this fatal disease.

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“…The activated PSCs exhibit tumor‐promoting effects via complicated interactions with pancreatic cancer cells and other cellular or noncellular components, as well as the fibrosis in PDAC tumor microenvironments. We speculated that PSCs or other cancer‐associated fibroblasts (CAFs) may have a marked influence on promoting cancer cell proliferation and invasion through PDGF/PDGFR, stromal‐derived factor‐1/CXCR4, the IGF‐1/IGF1R signaling pathway, and MMP‐2/9 secretion, and these promotion effects could be reversed by resveratrol treatment …”

Section: The Role Of Resveratrol In the Tumor Microenvironmentmentioning

confidence: 99%

Resveratrol and cancer treatment: updates

Jiang

Chen

Liu

et al. 2017

Annals of the New York Academy of Sciences

113

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Cancer, a growing health problem worldwide, affects millions of people every year. The overall survival rates of most cancers have been prolonged owing to the efforts of clinicians and scientists. However, some tumors develop resistance to chemoradiotherapeutic agents, and the cancer research community continues to search for effective sensitizers. Resveratrol, a natural polyphenolic phytoalexin, has shown promising effects in inhibiting proliferation and cancer progression in several tumor models. However, its molecular mechanisms and applications in chemotherapy and radiotherapy have yet to be fully determined. In this concise review, we highlight the role and related molecular mechanisms of resveratrol in cancer treatment. In particular, we focus on the role of resveratrol in the tumor microenvironment and the sensitization of cancer cells for chemotherapy and radiotherapy. Resveratrol shows promising efficacies in cancer treatment and may be applied in clinical therapy, but it requires further clinical study.

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Galectin-1-driven upregulation of SDF-1 in pancreatic stellate cells promotes pancreatic cancer metastasis

Cited by 53 publications

References 46 publications

Targeting Pancreatic Stellate Cells in Cancer

Targeting Pancreatic Stellate Cells in Cancer

The Galectin Family as Molecular Targets: Hopes for Defeating Pancreatic Cancer

Resveratrol and cancer treatment: updates

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