Galectin 1 overexpression in breast cancer tissues: Relation to serum matrix metalloproteinase 2 and 9 activity

Louka, Manal L.; Said, Hazem; Sayed, Sara El; El-Shinawi, Mohamed

doi:10.1016/j.genrep.2017.04.002

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…[31][32][33] Among them, overexpression of galectin-1 has been linked with breast cancer. [31,32,[34][35][36][37][38] Galectin-1 has been correlated with an increased tumor aggressiveness and poor prognosis, due to its ability to promote cell adhesion, leading to metastasis. [31,32,39] It has been shown that the suppression of galectin-1 can prevent both tumor growth and metastasis.…”

Section: Introductionmentioning

confidence: 99%

Targeted photodynamic therapy of breast cancer cells using lactose-phthalocyanine functionalized gold nanoparticles

Calavia

Chambrier

Cook

et al. 2018

Journal of Colloid and Interface Science

104

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Gold nanoparticles (AuNPs), which have been widely used for the delivery of photosensitizers for photodynamic therapy (PDT) of cancer, can be dispersed in aqueous solutions improving the delivery of the hydrophobic photosensitizer into the body. Furthermore, the large surface of AuNPs can be functionalized with a variety of ligands, including proteins, nucleic acids and carbohydrates, that allow selective targeting to cancer tissue. In this study, gold nanoparticles were functionalized with a mixed monolayer of a zinc phthalocyanine and a lactose derivative. For the first time, a carbohydrate was used with a dual purpose, as the stabilizing agent of the gold nanoparticles in aqueous solutions and as the targeting agent for breast cancer cells. The functionalization of the phthalocyanine-AuNPs with lactose led to the production of water-dispersible nanoparticles that are able to generate singlet oxygen and effect cell death upon irradiation. The targeting ability of lactose of the lactose-phthalocyanine functionalized AuNPs was studied in vitro towards the galectin-1 receptor on the surface of breast cancer cells. The targeting studies showed the exciting potential of lactose as a specific targeting agent for galactose-binding receptors overexpressed on breast cancer cells.

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Section: Introductionmentioning

confidence: 99%

Targeted photodynamic therapy of breast cancer cells using lactose-phthalocyanine functionalized gold nanoparticles

Calavia

Chambrier

Cook

et al. 2018

Journal of Colloid and Interface Science

104

View full text Add to dashboard Cite

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“…This activity was demonstrated to be related to the Treg activation component of the immune system 20 . In addition, the increase in expression of galectin-1 was directly proportional to MMP-1/2, and associated with tumor metastasis and angiogenesis 21 . However, in other studies, galectin-1 had the effect of inhibiting the proliferation and metabolic activity of breast cancer cells 22 .…”

Section: Dendritic Cells (Dcs)mentioning

confidence: 97%

The role of tumor-derived exosomes in tumor immune escape: A concise review

et al. 2020

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Exosomes are small vesicles secreted by viable cells into the microenvironment. These vesicles bring various compositions, including lipids, RNAs and proteins, which carry information from producer cells to target cells. Cancer cells also produce exosomes, termed as tumor-derived exosomes (TDEs), which play important roles in immune modulation, angiogenesis and metastasis of tumors. This review summarizes the roles of TDEs in tumor immune escape mechanisms. TDEs affect all kinds of tumor-associated immune cells, including natural killer (NK) cells, dendritic cells (DCs), T and B lymphocytes, and myeloid-derived suppressor cells (MDSCs). Generally, TDEs suppress the immune system to promote tumor immune escape, thereby significantly contributing to tumorigenesis and metastasis.

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Proteomic Analysis of Anti-Cancer Effects of Streblus Asper Extract on HeLa Cancer Cells

Roslan

Seeni

Ismail

et al. 2019

Biomed. Pharmacol. J.

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Cervical cancer is the third most common cancer affecting women worldwide. This occurs despite having precancerous screening and HPV vaccination implemented vigorously as a definitive intervention. Natural plant like Streblus asper has been discovered to offer great hope in treating and preventing cancers. In this study, we explored the potential of S.asper to inhibit the growth of cervical cancer cell line by using liquid chromatography mass spectrometry (LCMS). Upon analysis, seventy-six proteins that are common to both untreated and treated groups were identified. Of this, 14 proteins are found differentially expressed more than 2-fold changes. Based on past literature, we selected 7 proteins that are closely associated with treatment effects. These include Dermcidin, Keratin, type I cytoskeletal 9, Tropomyosin alpha-4 chain, Myristoylated alanine-rich C-kinase (MARCKS), Tumour protein D52, Folate receptor alpha, and Parathymosin. Pathway enrichment analysis by Reactome revealed 9 related pathways which include metabolism of protein, post-translational protein modification, signalling by Rho GTPases, signalling by NOTCH, cell cycle, cellular senescence, signalling by WNT, transcriptional regulation by TP53, and cellular responses to stress. These findings may improve our understanding on the related significant mechanism involving anti-cancer effects of S.asper on the cervical cancer cell line.

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Galectin 1 overexpression in breast cancer tissues: Relation to serum matrix metalloproteinase 2 and 9 activity

Cited by 3 publications

References 34 publications

Targeted photodynamic therapy of breast cancer cells using lactose-phthalocyanine functionalized gold nanoparticles

Targeted photodynamic therapy of breast cancer cells using lactose-phthalocyanine functionalized gold nanoparticles

The role of tumor-derived exosomes in tumor immune escape: A concise review

Proteomic Analysis of Anti-Cancer Effects of Streblus Asper Extract on HeLa Cancer Cells

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