Galectin-13/PP-13 expression in term placentas of gestational diabetes mellitus pregnancies

Unverdorben, Laura; Hüttenbrenner, Rebecca; Knabl, Julia; Jeschke, Udo; Hutter, Stefan

doi:10.1016/j.placenta.2014.11.019

Cited by 23 publications

(31 citation statements)

References 43 publications

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“…In the present study, we found significantly higher PP13 levels in the sera of women with GDM in the early second trimester, and PP13 holds the value of the prediction of subsequent GDM, which is consistent with previous studies. Unverdorben et al . found lower PP13 levels in term placentas of women with GDM in comparison with healthy controls, and the inconsistency of the present study might be caused by the difference of the time and organs of detection (placentas vs sera).…”

Section: Discussioncontrasting

confidence: 86%

“…Placental protein 13 (PP13) was reported to have a homologous structure to the galectin family, known in various human tissues, such as cells of the immune system, endometrium, placenta and endothelial tissue. Previously, a study reported a relationship between serum PP13 and GDM in the third trimester of pregnancy. Pentraxin 3 (PTX3) is an essential component of innate immunity and is independently associated with the risk of developing vascular events.…”

Section: Introductionmentioning

confidence: 99%

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Early second trimester maternal serum markers in the prediction of gestational diabetes mellitus

Zhao

Han

Meng

et al. 2018

J of Diabetes Invest

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Aims/IntroductionTo determine whether maternal serum markers in the early second trimester are useful for prediction of gestational diabetes mellitus (GDM).Materials and methodsA total of 876 singleton pregnancies were recruited in the present study. Blood samples were collected during 16–20 gestational weeks. GDM women were diagnosed by an oral glucose tolerance test during 24–28 gestational weeks. A total of 56 women with GDM and 73 healthy pregnant women were selected. Maternal serum concentrations of placental protein 13 (PP13), pentraxin 3 (PTX3), soluble fms‐like tyrosine kinase‐1 (sFlt‐1), myostatin and follistatin (FST) were detected at 16–20 weeks’ gestation. All of these markers concentrations were expressed as multiples of the medians. The Mann–Whitney U‐test was used for comparison of the multiples of the medians of different concentrations of these five serum markers between the GDM group and the control group. Receiver operating characteristic curve analysis was applied to assess the sensitivity and specificity of significant serum markers from a Mann–Whitney U‐test comparison.ResultsCompared with healthy pregnancies, the serum levels of PP13, PTX3, sFlt‐1, myostatin and FST in the early second trimester were significantly increased in patients who had developed GDM late. In screening for GDM by PP13, PTX3, sFlt‐1, myostatin and FST, the detection rates were 92.3, 94.9, 94.9, 92.5 and 92.3%, respectively at 80% specificity. PTX3 and sFlt‐1 were the most sensitive markers.ConclusionsMaternal serum markers including PP13, PTX3, sFlt‐1, myostatin and FST increase in the early second trimester of women with GDM. These five markers, especially PTX3 and sFlt‐1, could have the value of prediction for those patients who would develop GDM in the late second trimester.

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Section: Discussioncontrasting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Early second trimester maternal serum markers in the prediction of gestational diabetes mellitus

Zhao

Han

Meng

et al. 2018

J of Diabetes Invest

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“…Similarly, the evidence about resistin levels in this gestational complication are contradictory (Lobo et al, 2013). On the other hand, PAPP-A levels are also decreased in the first trimester of women that are later diagnosed with GDM (Beneventi et al, 2014;Lovati et al, 2013), and a recent study showed that PP13 levels are decreased in the third trimester of women with GDM (Unverdorben et al, 2015).…”

Section: Gestational Diabetes Mellitusmentioning

confidence: 99%

The endocrine function of human placenta: an overview

Costa

2016

Reproductive BioMedicine Online

272

173

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During pregnancy, several tightly coordinated and regulated processes take place to enable proper fetal development and gestational success. The formation and development of the placenta is one of these critical pregnancy events. This organ plays essential roles during gestation, including fetal nourishment, support and protection, gas exchange and production of several hormones and other mediators. Placental hormones are mainly secreted by the syncytiotrophoblast, in a highly and tightly regulated way. These hormones are important for pregnancy establishment and maintenance, exerting autocrine and paracrine effects that regulate decidualization, placental development, angiogenesis, endometrial receptivity, embryo implantation, immunotolerance and fetal development. In addition, because they are released into maternal circulation, the profile of their blood levels throughout pregnancy has been the target of intense research towards finding potential robust and reliable biomarkers to predict and diagnose pregnancy-associated complications. In fact, altered levels of these hormones have been associated with some pathologies, such as chromosomal anomalies or pre-eclampsia. This review proposes to revise and update the main pregnancy-related hormones, addressing their major characteristics, molecular targets, function throughout pregnancy, regulators of their expression and their potential clinical interest.

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“…Additionally, gal-13 is involved in trophoblast migration towards the placental bed via binding to beta and gamma-actin [ 28 ]. These effects concerning trophoblast development have been described in various ways, and decreased expression of gal-13 has also been shown in all placenta compartments of patients with gestational diabetes [ 29 ]. However, by now, gal-13 has not been implemented as a solitary or combined marker, neither for PE, nor for IUGR, lacking accuracy for screening purposes [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…Colon tissue was also used as a positive control for galectin-3 expression ( Figure 10 C) [ 43 ]. Galectin-13 expression was only described in placental tissue [ 29 ]. Negative controls are shown as inserts in each figure.…”

Section: Methodsmentioning

confidence: 99%

Placental Expression Patterns of Galectin-1, Galectin-2, Galectin-3 and Galectin-13 in Cases of Intrauterine Growth Restriction (IUGR)

Hutter

Knabl

Andergassen

et al. 2016

IJMS

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Galectins (gal) are members of the mammalian β-galactoside-binding proteins and recognize Galβ1-4GlcNAc and Galβ1-4GalNac (Thomsen-Friedenreich antigen (TF)) sequences of several cell surface oligosaccharides. In this study, gal-1, -2, -3 and -13 were investigated systematically in the trophoblast and decidua compartment of intrauterine growth restriction (IUGR) placentas and normal third trimester control placentas and stratified by fetal gender and gestational age. Within this study, 29 third trimester placentas after delivery were analyzed. Fetal gender was equally divided within both groups, and immunohistochemical staining was analyzed according to fetal gender and gestational age. Double immune-fluorescence with trophoblast-specific markers was used to identify galectin-expressing cells at the feto-maternal interface in the decidua. Gal-3 was significantly downregulated only in the extravillous trophoblast of IUGR placentas. In contrast, expressions of gal-2 and gal-13 were downregulated in both villous and extravillous trophoblast cells of IUGR placentas. In addition, gal-2 and gal-13 showed a highly correlated expression scheme in the placenta. There are significant gender-specific expression patterns for single prototype galectins with downregulation of gal-2 and gal-13 of male gender placentas in cases of IUGR. Gal-3 as the chimera type galectin shows only little gender-specific differences in expression, which disappear in IUGR cases.

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Galectin-13/PP-13 expression in term placentas of gestational diabetes mellitus pregnancies

Cited by 23 publications

References 43 publications

Early second trimester maternal serum markers in the prediction of gestational diabetes mellitus

Early second trimester maternal serum markers in the prediction of gestational diabetes mellitus

The endocrine function of human placenta: an overview

Placental Expression Patterns of Galectin-1, Galectin-2, Galectin-3 and Galectin-13 in Cases of Intrauterine Growth Restriction (IUGR)

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