Galectin-3 as a biomarker in breast neoplasms: Mechanisms and applications in patient care

Niang, Doudou Georges Massar; Gaba, Folly Mawulolo; Diouf, Adame; Hendricks, Jacobus; Diallo, Rokhaya Ndiaye; Niang, Maguette Sylla; Mbengué, Babacar; Dièye, Alioune

doi:10.1002/jlb.5mr0822-673r

Cited by 5 publications

(3 citation statements)

References 149 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…At present, there are two commonly used treatments for breast cancer in clinical practice: axillary lymph node dissection and radical mastectomy [14]. Although efficacy of these two treatments is good, there is significant surgical trauma with an extremely high probability of stress response in patients during surgery; this can result in severe damage to peripheral nerves in the breast tissue [15].…”

Section: Discussionmentioning

confidence: 99%

Ultrasound-guided thoracic paravertebral nerve block in patients undergoing radical mastectomy

2023

European Journal of Gynaecological Oncology

View full text Add to dashboard Cite

This research aims to investigate the effect of ultrasound-guided continuous thoracic paravertebral nerve block in patients undergoing radical mastectomy. Ninety-six patients who underwent radical mastectomy were equally divided into a study group (administered with a continuous thoracic paravertebral nerve block and general anesthesia) and a control group (given conventional general anesthesia) with a random number table. At T2–T4 (T2: immediate tracheal intubation; T3: at skin incision; T4: at extubation), mean artery pressure (MAP) and hear rate (HR) were significantly lower in the study group (p < 0.05); however, there was no significant difference in blood oxygen saturation (SpO2) between the two groups at different time points. At T2–T4, cortisol (Cor) levels were significantly lower in the study group (p < 0.05). At T0–T2, there was no significant difference in the levels of adrenocorticotropic hormone (ACTH) between the two groups. At T3–T4, the levels of ACTH in the study group were significantly lower (p < 0.05). There were no significant differences in blood pressure between the two groups at any time point. At the moment of discharge from the resuscitation room and 2 hours after surgery, the numerical rating scale (NRS) score in the study group was significantly reduced (p < 0.05). The incidence of adverse reactions in the study group was 10.42%; this was lower than that in the control group (33.33%) (p < 0.05). Finally, the use of fentanyl and propofol, and the frequency of analgesic pump use, were significantly lower in the study group (p < 0.05). Ultrasound-guided thoracic paravertebral nerve block can effectively maintain hemodynamic stability, improve the stress response, reduce postoperative pain, reduce the use of anesthetic drugs, and effectively control the incidence of adverse reactions in patients undergoing radical mastectomy.

show abstract

Section: Discussionmentioning

confidence: 99%

Ultrasound-guided thoracic paravertebral nerve block in patients undergoing radical mastectomy

2023

European Journal of Gynaecological Oncology

View full text Add to dashboard Cite

show abstract

“…Galectin-3 contributes to various pathophysiological processes, including inflammation and fibrosis, cancer cell proliferation, adhesion, angiogenesis, cell migration, T-lymphocytes apoptosis and macrophage differentiation into infiltrative forms that stabilize tumor environments and polarization of tumor-associated macrophages [ 3 , 4 , 5 , 6 , 7 , 8 ]. Because of its disease-specific overexpression, human Gal-3 (hGal-3) has been proposed to be a therapeutic target and a biomarker of different pathological conditions including cancer and cardiovascular diseases [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Selectively Modified Lactose and N-Acetyllactosamine Analogs at Three Key Positions to Afford Effective Galectin-3 Ligands

Abdullayev

Kadav

Bandyopadhyay

et al. 2023

IJMS

View full text Add to dashboard Cite

Galectins constitute a family of galactose-binding lectins overly expressed in the tumor microenvironment as well as in innate and adaptive immune cells, in inflammatory diseases. Lactose ((β-D-galactopyranosyl)-(1→4)-β-D-glucopyranose, Lac) and N-Acetyllactosamine (2-acetamido-2-deoxy-4-O-β-D-galactopyranosyl-D-glucopyranose, LacNAc) have been widely exploited as ligands for a wide range of galectins, sometimes with modest selectivity. Even though several chemical modifications at single positions of the sugar rings have been applied to these ligands, very few examples combined the simultaneous modifications at key positions known to increase both affinity and selectivity. We report herein combined modifications at the anomeric position, C-2, and O-3′ of each of the two sugars, resulting in a 3′-O-sulfated LacNAc analog having a Kd of 14.7 µM against human Gal-3 as measured by isothermal titration calorimetry (ITC). This represents a six-fold increase in affinity when compared to methyl β-D-lactoside having a Kd of 91 µM. The three best compounds contained sulfate groups at the O-3′ position of the galactoside moieties, which were perfectly in line with the observed highly cationic character of the human Gal-3 binding site shown by the co-crystal of one of the best candidates of the LacNAc series.

show abstract

“…Сегодня в качестве одного из перспективных маркеров онкологических заболеваний рассматривается представитель семейства лектинов галектин-3 [2,3]. Идентифицировано 15 галектинов, которые делят на три типа: прототипы галектинов с одним одиночным доменом распознавания углеводов; галектины с тандемными повторами и двумя одиночными доменами распознавания углеводов; галектины химерного типа с одним одиночным доменом распознавания углеводов [4].…”

unclassified

Galectin-3 and matrix metalloproteinases 2 and 9 in peripheral blood of gastric cancer patients

Короткова¹,

Samoilova³

et al. 2023

Almanac of Clinical Medicine

View full text Add to dashboard Cite

Background: High incidence of gastric cancer (GC), its aggressive clinical course, rapid tumor dissemination, low sensitivity to chemotherapy and lack of reliable laboratory diagnostic criteria urgently require a search for the most informative markers associated with key biologic properties of the tumors. Aim: Comparative analysis of galectin-3, matrix metalloproteinase (MMP)-2, and MMP-9 levels in peripheral blood of GC patients and healthy donors, assessment of association of these markers with clinical morphological characteristics of the disease, and prognosis of overall and relapse-free survival. Materials and methods: Sixty (60) primary treatment-nave GC patients (38 men, 22 women) aged 29 to 81 years and 90 healthy donors compatible with their age and sex were included into the study. Galectin-3 was measured in EDTA plasma, MMP-2 and MMP-9 in serum with standard direct enzyme immunoassay kits "Human MMP-2 (total)", "Human MMP-9 (total)", "Human Galectin-3" (RD Systems, USA). Results: Plasma galectin-3 concentration in the GC patients was significantly higher than in the healthy controls (median 12.9 and 10.6 ng/ml, respectively; p 0.0001). No difference in serum MMP-9 levels between GC patients and control subjects were found, while MMP-2 level in the control group was significantly higher, than in the GC patients (p = 0.039). No association between galectin-3, MMP-2, and MMP-9 blood levels in the GC patients could be identified. In contrast to GC patients, there was a positive correlation of plasma galectin-3 with age in the control group (rs = 0.51, p 0.005). No associations between the biomarkers levels in blood and clinical and morphological characteristics of GC were established, except MMP-9 being higher at Т4а invasion depth as compared to the earlier Т2 level. Marked differences in the overall survival depending on plasma galectin-3 levels were found, with the cut-off level of 12.9 ng/ml: the 5-year overall survival in the patients with low galectin-3 was better, than in those with its higher level (50 and 43%, respectively; however, the difference was non-significant, р 0.1). Both overall and relapse-free survival of the GC patients was higher in those with low ( 212 ng/ml) serum MMP-2: the 5-year overall survival in this group comprised 60% versus 23% in the patients with higher MMP-2 (p = 0.018). The difference in relapse-free survival was non-significant. Serum MMP-9 levels had no significant impact on the survival of GC patients. Conclusion: The ambiguous data on the clinical role of galectin-3, MMP-2, MMP-9 in GC obtained in this study indicate the necessity of further investigation of their possible utility for the diagnostics and prognosis of treatment results.

show abstract

Galectin-3 as a biomarker in breast neoplasms: Mechanisms and applications in patient care

Cited by 5 publications

References 149 publications

Ultrasound-guided thoracic paravertebral nerve block in patients undergoing radical mastectomy

Ultrasound-guided thoracic paravertebral nerve block in patients undergoing radical mastectomy

Selectively Modified Lactose and N-Acetyllactosamine Analogs at Three Key Positions to Afford Effective Galectin-3 Ligands

Galectin-3 and matrix metalloproteinases 2 and 9 in peripheral blood of gastric cancer patients

Contact Info

Product

Resources

About