Galectin-3: can it be a diagnostic tool for pneumonia in covid-19 patients?

Baykan, Emine Kartal; Şebin, Engin; Karaşahin, Ömer; Baykan, Ahmed Ramiz; Cerrah, Serkan; Göğebakan, Hasan; Sevinç, Can; Kahraman, Mustafa; Yavuz, Yasemin

doi:10.3906/sag-2102-202

Cited by 5 publications

(4 citation statements)

References 32 publications

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“…Single-cell analysis found elevated levels of galectin-3 in monocytes, macrophages, and dendritic cells of patients with severe COVID-19 as compared to mild cases [81]. Serum galectin-3 concentrations were an independent predictor of severe outcome, which was defined as the need for invasive mechanical ventilation [82] and was also a predictor of severe pneumonia [78,84,86]. Furthermore, galectin-3 levels at admission were risk factors for the need of intensive care and advanced ventilatory support [87].…”

Section: Galectin-3mentioning

confidence: 99%

Adipokines as Diagnostic and Prognostic Markers for the Severity of COVID-19

Grewal

Buechler

2023

Biomedicines

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Accumulating evidence implicates obesity as a risk factor for increased severity of disease outcomes in patients infected with severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). Obesity is associated with adipose tissue dysfunction, which not only predisposes individuals to metabolic complications, but also substantially contributes to low-grade systemic inflammation, altered immune cell composition, and compromised immune function. This seems to impact the susceptibility and outcome of diseases caused by viruses, as obese people appear more vulnerable to developing infections and they recover later from infectious diseases than normal-weight individuals. Based on these findings, increased efforts to identify suitable diagnostic and prognostic markers in obese Coronavirus disease 2019 (COVID-19) patients to predict disease outcomes have been made. This includes the analysis of cytokines secreted from adipose tissues (adipokines), which have multiple regulatory functions in the body; for instance, modulating insulin sensitivity, blood pressure, lipid metabolism, appetite, and fertility. Most relevant in the context of viral infections, adipokines also influence the immune cell number, with consequences for overall immune cell activity and function. Hence, the analysis of the circulating levels of diverse adipokines in patients infected with SARS-CoV-2 have been considered to reveal diagnostic and prognostic COVID-19 markers. This review article summarizes the findings aimed to correlate the circulating levels of adipokines with progression and disease outcomes of COVID-19. Several studies provided insights on chemerin, adiponectin, leptin, resistin, and galectin-3 levels in SARS-CoV-2-infected patients, while limited information is yet available on the adipokines apelin and visfatin in COVID-19. Altogether, current evidence points at circulating galectin-3 and resistin levels being of diagnostic and prognostic value in COVID-19 disease.

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Section: Galectin-3mentioning

confidence: 99%

Adipokines as Diagnostic and Prognostic Markers for the Severity of COVID-19

Grewal

Buechler

2023

Biomedicines

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“…In Baykan et al’s study, patients with a diagnosis of COVID-19 infection and typical and atypical pneumonia findings on thorax CT were evaluated and the usability of Galectin-3 level as a diagnostic tool in COVID-19 pneumonia was calculated. The results showed that Galectin-3 level was higher in patients with typical pneumonia findings on thorax CT [ 14 ]. In addition, the Galectin-3 level was found to be higher in the patient group than in the control group.…”

Section: Discussionmentioning

confidence: 99%

“…Although a prospective study has been conducted to evaluate the role of Galectin-3 inhibitors in the treatment of COVID-19 previously, to the authors’ knowledge, there is no study examining the change of Galectin-3 protein level at the clinical level in COVID-19, and few studies have examined the usability of Galectin-3 level in the diagnosis of COVID-19 pneumonia [ 13 , 14 ]. This study aims to investigate the role of the Galectin-3 level in the diagnosis of COVID-19 pneumonia and the value of the Galectin-3 level in predicting the clinical course of the patient.…”

Section: Introductionmentioning

confidence: 99%

Galectin-3 as a Potential Prognostic Biomarker for COVID-19 Disease: A Case-Control Study

Karslı¹,

Metin²,

Çanacık³

et al. 2022

Cureus

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BackgroundRecent studies have investigated the importance of Galetin-3 in inflammation, fibrosis, cell proliferation, cardiac disease, diabetes, and tumor formation. AimsThis study aims to investigate the role of the Galectin-3 level in the diagnosis of COVID-19 pneumonia and the value of the Galectin-3 level in predicting the clinical course of the patient. MethodsThis study employed a prospective, case-control study design and was conducted at Bakircay University Ciğli Training and Research Hospital. A total of 100 patients (40 had moderate and 60 had severe/critical COVID-19 disease according to World Health Organisation guidelines) and 50 non-symptomatic healthy volunteers participated in the study. Blood samples were taken from patients at the time of hospital admission, after which serum was isolated. Following the isolation of serum, Galectin-3 levels were evaluated using the enzyme-linked immunosorbent assay (ELISA) method. ResultsThe serum Galectin-3 level was measured as 13.57 (10.9-16.4) ng/mL in the control group, 13.52 (10.69-16.6) ng/mL in the moderate disease group, and 11.65 (6.09-14.33) ng/mL in the severe/critical disease group. Serum Galectin-3 levels were significantly lower in the severe/critical disease group compared to the control and moderate disease groups (p=0.001 and p=0.019, respectively).Using ROC analysis, a larger area under the curve (AUC) for the serum Galectin-3 levels of the control group (AUC=0.622, 95% CI =0.529-0.714; p=0.015) was calculated compared to the COVID-19 patient group for the diagnosis of COVID-19 disease. The Galectin-3 level was found to be 75% sensitive and 50% specific at a cutoff level of 11.3 ng/mL in predicting the need for ICU treatment. ConclusionGalectin-3 levels may be a beneficial biomarker in predicting the clinical severity of COVID-19 disease when used in conjunction with other known biomarkers, at the time of admission to the emergency department (ED).

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“… 71 In a study examining galectin-3 levels in COVID-19 patients, it was revealed that galectin-3 may be a diagnostic tool for typical pneumonia associated with COVID-19 and an indicator of the severity of pneumonia. 72 In a study investigating the effects of laboratory parameters on the prognosis of COVID-19, it was concluded that an increase in CRP, procalcitonin, erythrocyte sedimentation rate, ferritin, troponin, d -dimer, lactate dehydrogenase, and neutrophil count and a decrease in albumin, platelet, and lymphocyte count were associated with the severity of the disease. 73 In a similar study, prognostic laboratory parameters for COVID-19 were investigated in a group of geriatric patients with high mortality risk, and it was concluded that a high neutrophil/lymphocyte ratio was an independent risk factor for mortality.…”

mentioning

confidence: 99%

Review of Medical Studies on COVID-19 During the Pandemic Period

Aksakal¹,

Kerget²

2023

Eurasian J Med

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Due to the COVID-19 pandemic, both the university hospital and the city hospital have faced a significant patient load in our city. During this period, academic articles were written that contributed significantly to the literature on both hospitals struggling with patient density. In our study, we aimed to compile medical articles about COVID-19 in our city using the Web of Science and PubMed database.

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Galectin-3: can it be a diagnostic tool for pneumonia in covid-19 patients?

Cited by 5 publications

References 32 publications

Adipokines as Diagnostic and Prognostic Markers for the Severity of COVID-19

Adipokines as Diagnostic and Prognostic Markers for the Severity of COVID-19

Galectin-3 as a Potential Prognostic Biomarker for COVID-19 Disease: A Case-Control Study

Review of Medical Studies on COVID-19 During the Pandemic Period

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