Galectin-3 expression in parathyroid carcinoma: immunohistochemical study of 26 cases

Bergero, Nicoletta; Pompa, Roberta De; Sacerdote, Carlotta; Gasparri, Guido; Volante, Marco; Bussolati, Gianni; Papotti, Mauro

doi:10.1016/j.humpath.2005.06.020

Cited by 76 publications

(70 citation statements)

References 22 publications

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“…Our finding that galectin-3 was overexpressed in parathyroid carcinomas (14 of 15, 92.3%), parathyroid adenomas (1 of 18, 5.6%), and hyperplastic parathyroid glands (2 of 14, 14.3%) agrees with those of previous studies. 21,23 One study found that 2 thirds of cases with MEN syndrome were positive for galectin-3. 23 In our study, 2 of the 3 specimens of hyperplasia obtained from patients with secondary hyperparathyroidism and chronic renal failure demonstrated positive focal and weak galectin-3 staining, whereas all other sporadic primary and MEN1 hyperplastic glands did not.…”

Section: Discussionmentioning

confidence: 99%

“…Our results are supported by those from several previous studies. 11,15,21 The tumor suppressor gene Rb has been extensively studied in parathyroid tumors. [16][17][18][19][20] There has been considerable debate about whether the presence of loss of heterozygosity at the locus of the Rb gene, and the corresponding mutation and the absence of protein expression, contribute to parathyroid tumorigenesis.…”

Section: Discussionmentioning

confidence: 99%

“…Tumors were grouped as having normal or abnormal protein expression according to previously established cutoff values obtained from different immunohistochemistry studies. 11,19,21,28 The staining pattern for parafibromin, Rb, Ki-67, and p27 is nuclear, whereas that for galectin-3 and mdm-2 is both nuclear and cytoplasmic. For parafibromin, galectin-3, and Rb proteins, immunostaining was considered positive when specific staining was present and negative when no specific immunostaining was detected.…”

Section: Immunostaining Scoringmentioning

confidence: 99%

“…[16][17][18][19][20] Increased expression of Ki-67 corresponds with increased cellular proliferation and contributes to tumorigenesis in many organs, but does not distinguish accurately between benign and malignant parathyroid tumors. 11,15,20,21 The galectin-3 (LGALS3)…”

mentioning

confidence: 99%

“…22 Galectin-3 reportedly helps distinguish benign from malignant parathyroid tumors. 21,23 Finally, the HRPT2 gene encodes a 531 amino acid protein (parafibromin) that is an accessory factor for RNA polymerase II as part of the human Paf1 complex, and is a regulator of transcription. Inactivation of the HRPT2 tumor suppressor gene is associated with HHJTS and several sporadic parathyroid carcinomas.…”

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confidence: 99%

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Defining a molecular phenotype for benign and malignant parathyroid tumors

Fernández-Ranvier

Khanafshar

Tacha

et al. 2009

Cancer

101

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BACKGROUND:It is frequently difficult to establish histologically whether a parathyroid tumor is a parathyroid carcinoma, parathyromatosis, or an atypical adenoma. The authors asked whether these tumors have a distinctive molecular profile, whether benign tumors could be distinguished from malignant tumors, and whether parathyromatosis is a low‐grade parathyroid carcinoma or is benign tissue that can invade other organs.METHODS:Samples of parathyroid carcinoma, atypical adenoma, parathyromatosis, parathyroid adenoma, and hyperplasia were obtained for tissue microarray studies. The molecular expression of genes involved in parathyroid tumor progression (HRPT2 [“parafibromin”], galectin‐3, Ki‐67, Rb, p27, and mdm‐2) was investigated by immunohistochemistry.RESULTS:Complete loss of parafibromin expression was seen in 5 of 16 (31.3%) parathyroid carcinomas; all parathyromatosis, atypical adenomas, adenomas, and hyperplasia stained positive for parafibromin. Loss of Rb expression was seen in 5 (33.3%) of 15 parathyroid carcinomas and 1 (7.1%) of 14 parathyroid hyperplasias; all parathyromatosis, atypical adenomas, and adenomas stained positive. Galectin‐3 stained strongly positive in 14 (93.3%) of 15 parathyroid carcinomas, and positive in 3 (18.7%) of 16 cases of parathyromatosis, 2 (100%) of 2 atypical adenomas, 1 (5.6%) of 18 adenomas, and 2 (14.3%) of 14 hyperplasias. The Ki‐67 proliferative index was high in 9 (60%) of 15 parathyroid carcinomas, 1 (6.7%) of 15 cases of parathyromatosis, 1 (5.6%) of 18 adenomas, and no atypical adenomas or hyperplasia. P27 and mdm‐2 protein expression did not differ appreciably among the tumor types.CONCLUSIONS:No single diagnostic marker currently determines whether a parathyroid tumor is a parathyroid carcinoma, but loss of parafibromin and Rb expression, and overexpression of galectin‐3, generally distinguish parathyroid carcinoma from other parathyroid tumors. Parathyromatosis does not appear to be a low‐grade parathyroid carcinoma. Cancer 2009. © 2009 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Immunostaining Scoringmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Defining a molecular phenotype for benign and malignant parathyroid tumors

Fernández-Ranvier

Khanafshar

Tacha

et al. 2009

Cancer

101

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Parathyroid Carcinoma

Veloski

Ridge

2017

Textbook of Uncommon Cancer

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Synthesis of polystyrene‐b‐poly(ethylene‐co‐butene) block copolymers by anionic living polymerization and subsequent noncatalytic hydrogenation

Liang

Fan

2006

J of Applied Polymer Sci

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A series of polystyrene-b-polybutadiene (PStb-PBd) block copolymers with various chain lengths and compositions were synthesized by sequential living anionic polymerization and then converted into the corresponding polystyrene-b-poly(ethylene-co-butene) (PSt-b-PEB) block copolymers through the selective hydrogenation of unsaturated polybutadiene segments. Noncatalytic hydrogenation was carried out with diimide as the hydrogen source. The microstructures of PSt-b-PBd and PSt-b-PEB were investigated with gel permeation chromatography, 1 H-NMR, 13 C-NMR, Fourier transform infrared, and differential scanning calorimetry. The results showed that the hydrogenation reaction was conducted successfully and that the chain length and molecular weight distribution were not altered by hydrogenation.

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Galectin-3 expression in parathyroid carcinoma: immunohistochemical study of 26 cases

Cited by 76 publications

References 22 publications

Defining a molecular phenotype for benign and malignant parathyroid tumors

Defining a molecular phenotype for benign and malignant parathyroid tumors

Parathyroid Carcinoma

Synthesis of polystyrene‐b‐poly(ethylene‐co‐butene) block copolymers by anionic living polymerization and subsequent noncatalytic hydrogenation

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