Gall bladder dysfunction in chronic diabetics (type 2): an ultrasonography based prospective study

Garjesh, S.; Baghel, Vijay; Rai, Tina; Vyas, Mahendra Mohan

doi:10.18203/2320-6012.ijrms20160084

Cited by 6 publications

(7 citation statements)

References 14 publications

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“…Suggested that, hepatobiliary ultrasonography in chronic diabetics can be used as screening tool for early diagnosis of complication and to avoid its serious consequences when presents in emergency and undergone for surgery. [15] In our study the fasting GB Volume (cm 3 ) difference was not statistically significant between T2DM patients without complications and T2DM patients with complications, but there was significant difference between the two in the post fatty gallbladder volume with a mean value of 12 cm 3 in patients without complications and a mean value of 18.2 cm 3 in patients with complications. Furthermore, percentage of ejection fraction showed significant difference with a mean value of 56.91% in patients without complications and a mean value of 41.43 % in patients with complications.…”

Section: Discussioncontrasting

confidence: 62%

Evaluation of Gall Bladder Volume in Type 2 Diabetes Mellitus Patients Using Real Time Ultrasonography

Patil

2020

AJMRR

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Background: Diabetes mellitus is a group of metabolic diseases characterized by chronic hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Autonomic neuropathy manifests as esophageal dysfunction, nocturnal diarrhea, gall bladder dysfunction, sphincter disturbances, atonic bladder and orthostatic hypotension. The present study aimed to evaluate and compare the gall bladder volume in fasting and post prandial state by real time ultrasound in Type 2 Diabetes Mellitus (T2DM) patients and healthy controls. Subjects and Methods: In this cross sectional study, 90 subjects were included. Among them, 45 were type 2 diabetes mellitus patients included as cases and 45 age and sex matched healthy controls, who attended the Department of Medicine and Radio-diagnosis, Akash Institute of Medical Sciences & Research Centre, Devanahalli, Bengaluru, Karnaaka. All the study subjects were underwent detailed general and systemic examinations. Under aseptic conditions, 3ml fasting blood samples were collected and used for the estimation of fasting blood sugar, post prandial blood sugar. Gall bladder volume evaluation in fasting and 45 minutes post prandial (standardized fatty meal) state were done in T2DM patients and controls using real time ultrasound (GE Voluson P8 Mechine). Results: In the present study, BMI (24.78 2.31 kg/m2), FBS (160.98 27.99 mg/dl), PPBS (244.31 38.91 mg/dl), Fasting gall bladder volume (33.33 6.42 cm3), post fatty meal gall bladder volume (15.21 6.39 cm3), ejection fraction (49.34 17.29 cm3) were significantly increased in type 2 diabetes mellitus patients compared with healthy controls. Conclusion: The study results conclude that, fasting and post-prandial gallbladder volumes are indicative of gallbladder function. Patients with type 2 diabetes mellitus showed statistically significant impairment of gallbladder function. Gallbladder function may be evaluated routinely in type 2 diabetes mellitus patients.

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Section: Discussioncontrasting

confidence: 62%

Evaluation of Gall Bladder Volume in Type 2 Diabetes Mellitus Patients Using Real Time Ultrasonography

Patil

2020

AJMRR

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“…Long-term complications of HGB can include malignant conversion [4]. Several studies in the literature have uncovered that the risk of gallbladder disease overall is increased in those with diabetes mellitus [5-7]. A recent meta-analysis found that the risk of gallbladder diseases is increased by 56% amongst diabetic patients compared to the general population [5].…”

Section: Discussionmentioning

confidence: 99%

“…A recent meta-analysis found that the risk of gallbladder diseases is increased by 56% amongst diabetic patients compared to the general population [5]. Chronicity of diabetes itself has a positive correlation for this increased prevalence and progressive increase in gallbladder volume leading to hydrops [7].…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Perforation of an Acalculous Hydropic Gallbladder in a Diabetic Patient With Neuropathy: An Underdiagnosed Entity

2019

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Gallbladder hydrops (HGB) is often under-diagnosed due to the various diagnostic criteria used throughout the globe. It can be described as a progressive increase in the volume of the gallbladder in the absence of inflammation, or bacterial infection. The underlying mechanism involves biliary ductal obstruction due to gallstones. We describe a unique case of a diabetic patient who presented with symptoms of viral gastroenteritis and was incidentally found to have a non-traumatic spontaneous rupture of a hydropic gallbladder which resulted in septic shock and eventual death of the patient. We present this case together with a comprehensive literature review on why diabetic patients are at high risk of HGB and subsequent spontaneous perforation compared to the general population.

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“…Garjesh S Rai [26] et al compared gallbladder contractility in type 2 diabetes mellitus and nondiabetic patients. Their results showed that gallbladder contractility is reduced in diabetic patients more than nondiabetic patients.…”

Section: Discussionmentioning

confidence: 99%

Role of 99mTc-HIDA Scan for Assessment of Gallbladder Dyskinesia and Comparison of Gallbladder Dyskinesia with Various Parameters in Laparoscopic Cholecystectomy Patients

Thiyagarajan

Kamaraj

Navrathan

et al. 2019

Minimally Invasive Surgery

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Objectives. Pathogenesis of gallstone includes bile stasis due to defect in the gallbladder muscle contraction. Our aim of the study is to find out the role of 99mTc-HIDA scan in assessment of gallbladder dyskinesia in cholelithiasis patients before laparoscopic cholecystectomy and compare the gallbladder dyskinesia with various parameters like symptoms of patients, diabetic status of patients, gallstones size and number, and cholecystitis features in histopathology report after surgery. Material and Method. This is a prospective observational study conducted at our hospital for three years. Totally 40 patients with gallstone were subjected to 99mTc-HIDA scan, to assess the ejection fraction of gallbladder. For all these patients detailed clinical history, presence of comorbid illness like diabetics, and symptomatology were elicited. For all patients, ultrasonogram of abdomen was done to assess number and size of stones. All parameters were tabulated and correlated. Result. While comparing 99mTc-HIDA scan findings with symptoms of patients, 21.2% were asymptomatic and 78.8% symptomatic patients who had ejection fraction less than 80%. All patients in EF >80% group were symptomatic only. It is not statistically significant. On comparing 99mTc-HIDA scan findings with diabetic status of the patients, 42.4% of diabetic and 57.6 % of nondiabetic patients had ejection fraction less than 80%. It is not statistically significant (0.681). While comparing 99mTc-HIDA scan findings with size of the gallstone in ultrasound, 63.6% patients with size less than 1cm and 36.4% with size more than 1cm had ejection fraction < 80%. It is statistically significant (0.048). On comparing 99mTc-HIDA scan findings with number of stones in ultrasound, 18.2% single gallstone patients and 81.8% multiple gallstone patients had EF less than 80% which is statistically significant (0.001). While comparing the 99mTc-HIDA scan findings with histopathology report after laparoscopic cholecystectomy, 21.2% non-cholecystitis patients and 78.8% cholecystitis patients had EF less than 80%, which is statistically (0.017) significant. Conclusion. 99mTc-HIDA scan can be an accurate method to diagnose the gallbladder dyskinesia. Gallbladder dyskinesia in 99mTc-HIDA scan can be used to predict large size stones and multiple stones before surgery. The sensitivity can be improved by 99mTc-HIDA scan in diagnosing cholecystitis patients.

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Gall bladder dysfunction in chronic diabetics (type 2): an ultrasonography based prospective study

Cited by 6 publications

References 14 publications

Evaluation of Gall Bladder Volume in Type 2 Diabetes Mellitus Patients Using Real Time Ultrasonography

Evaluation of Gall Bladder Volume in Type 2 Diabetes Mellitus Patients Using Real Time Ultrasonography

Spontaneous Perforation of an Acalculous Hydropic Gallbladder in a Diabetic Patient With Neuropathy: An Underdiagnosed Entity

Role of 99mTc-HIDA Scan for Assessment of Gallbladder Dyskinesia and Comparison of Gallbladder Dyskinesia with Various Parameters in Laparoscopic Cholecystectomy Patients

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