Gallbladder Burkitt’s lymphoma mimicking gallbladder cancer: A case report

Abstract

BACKGROUND Malignant lymphoma is a rare form of gallbladder malignancy. Most of these malignancies are diffuse large B-cell lymphomas or mucosa-associated lymphoid tissue-type lymphomas; however, Burkitt’s lymphoma of the gallbladder is extremely rare, and only two previous reports are available in the literature. Herein, we report a rare case of Burkitt’s lymphoma of the gallbladder mimicking gallbladder adenocarcinoma. CASE SUMMARY An 83-year-old man with no abdominal complaints was found to have a gallbladder tumor and periportal lymph node enlargement on computed tomography (CT) performed for hypertension screening. His laboratory data revealed slightly elevated serum levels of carcinoembryonic antigen and soluble interleukin 2 receptor. Imaging examinations revealed two irregular and contrast-enhanced masses extending into the gallbladder lumen, but these did not infiltrate the serosa. Moreover, a periportal lymph node had enlarged to 30 mm. Based on these findings, we diagnosed the patient as having gallbladder adenocarcinoma with lymph node metastasis, which was treated using bile duct resection with gallbladder bed resection and periportal lymph node dissection. However, the patient was finally diagnosed as having Burkitt’s lymphoma. Although the surgical margin was pathologically negative, recurrence was noted at the hepatic radical margin and superior pancreaticoduodenal lymph nodes on positron emission tomography/CT soon after discharge. Thus, he was referred to a hematologist and started receiving treatment with reduced-dose cyclophosphamide, doxorubicin, vincristine, and prednisone. CONCLUSION Burkitt’s lymphoma can occur in the gallbladder. Biopsy can be useful in cases with findings suggestive of gallbladder malignant lymphoma.

Burkitt lymphoma in a scalp region: a case report of it’s recurrence in a 13-year-old child

“…Hosoda et al . 9 recounted a case of an 83-year-old man who had no symptoms about his abdomen but whose CT scan revealed an expansion of the periportal lymph node and a gallbladder tumor. The scan was done as part of a hypertension screening.…”

Gallbladder Burkitt’s Lymphoma in a Child Living with HIV: A Case Report

“…Malignant lymphoma of the gallbladder is a rare type of gallbladder malignancy, which encompasses 0.1%-0.2% of all gallbladder tumors [1][2][3][4]. In prior reports, the majority of them were described to be DLBCL or MZL [3,5].…”

“…That is because preoperative diagnosis is exceedingly challenging. Although several reports have documented malignant gallbladder lymphomas, most of these malignancies are diffuse large B-cell lymphomas (DLBCL) or Marginal Zone Lymphomas (MZL) [3,[5][6], and only three reports have previously documented gallbladder Burkitt's lymphoma (BL) [1,[7][8]. Herein, we report the first case of a child with gallbladder BL.…”

“…Malignant gallbladder lymphoma is particularly uncommon [1][2][3][4][5]. Mostly, patients diagnosed with this disease are referred for surgery with the diagnostic hypothesis of gallbladder adenocarcinoma or cholecystitis.…”

Typical and Atypical Imaging Features of Malignant Lymphoma in the Abdomen and Mimicking Diseases

“…Additionally, malignant lymphomas are aggressive and often involve extranodal sites at the time of initial diagnosis, but encase vessels without definite luminal narrowing ( Fig. 24 ) ( 14 41 47 ).…”