Gallbladder cancer in a regional hospital

Ocón, Francisco José Morera; Vicente, Javier Ballestín; Orts, Francisco Ripoll; Molina, Francisco Landete; Ximénez, Mario García-Granero; Tarín, José Millán; Rispoldi, Leonardo de Tursi; Sprekelsen, Juan Carlos Bernal

doi:10.1016/s2173-5077(09)70091-2

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…Literature review revealed that 0.3% to 4.6% of the patients who underwent cholecystectomy for presumed benign disease were found to have GBC with more common incidence in eastern than western countries. The proportion of GBC detected in patients undergoing cholecystectomy for cholelithiasis in our study was 0.5% and is quite comparable with other literature (Table 3) [17][18][19][20]. In the present retrospective study, reviewing 10 patients with GBC surgical treatment remains the only treatment modality associated with a benefit in terms of survival.…”

Section: Discussionsupporting

confidence: 89%

Incidental gallbladder carcinoma in laparoscopic cholecystectomy: Five years local experience

Ghnnam

Elbeshry²,

Malek³

et al. 2014

El Med J

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Section: Discussionsupporting

confidence: 89%

Incidental gallbladder carcinoma in laparoscopic cholecystectomy: Five years local experience

Ghnnam

Elbeshry²,

Malek³

et al. 2014

El Med J

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“…The incidence of GB Ca concurrent with XGC displayed little geographical variation, being present in 5.2% of XGC patients in the pooled cohort. This is higher than the reported incidence of GB Ca within cholecystectomy specimens which does vary according to geographical location and has been reported as being: in Europe 0.09 to 1.1% of patients, in India 0.59 to 1.9% and in the Far East as 0.3 to 4.7% . Gall stones were present in the majority of patients with XGC but not in every patient suggesting a causal role together with other as yet unidentified factors.…”

Section: Discussionmentioning

confidence: 99%

Xanthogranulomatous cholecystitis: a European and global perspective

Hale

Roberts

Hodson

et al. 2014

HPB

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XGC is a global disease and is associated with GB Ca. Characteristic pathological, radiological and clinical features are shared with GB Ca and contribute to considerable treatment inaccuracy. Tissue sampling by pre-operative endoscopic ultrasound or intra-operative frozen section is required to accurately diagnose gallbladder pathology and should be performed before any extensive resection is performed.

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“…These data were modeled against previously published mortality rates from laparoscopic cholecystectomy, 2,3 rates of common bile duct injury, [3][4][5][6][7][8][9] and rates of incidental gallbladder cancer. [10][11][12][13][14][15] Extrapolated costs of surveillance were then compared against previously published data regarding costs of treatment of cancer in the United Kingdom.…”

Section: Methodsmentioning

confidence: 99%

Risk and Cost-effectiveness of Surveillance Followed by Cholecystectomy for Gallbladder Polyps

Cairns¹,

Neal²,

Dennison³

et al. 2012

Arch Surg

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Main Outcome Measures: Demographic data and size and number of polyps were recorded as well as size increase and histological findings. Detection rates for potentially neoplastic and frankly neoplastic polyps were recorded and compared with complication rates from cholecystectomy. Cost-effectiveness of ultrasonography surveillance was examined. Results: Nine hundred eighty-six patients were identified and 467 patients underwent further follow-up. Only 6.6% of polyps exhibited an increase in size over the surveillance period. Polyps that subsequently progressed in size on surveillance had a significantly greater diameter at first presentation than those polyps that remained static (7 mm vs 5 mm, respectively) (PϽ.05). Only 3.7% of resected polyps had malignant or potentially malignant histology. Size greater than 10 mm and increase in size during surveillance predicted neoplastic potential. Conclusions: A surveillance with or without selective surgery policy could potentially detect and prevent 5.4 gallbladder cancers per 1000 individuals per year with a cost saving of more than £130 000 (US $201 676) per year. Cancer prevention benefits would exceed the risk ratios from cholecystectomy complications. Polyps greater than 10 mm should be resected; those between 5 and 10 mm should be under ultrasonography surveillance.

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Gallbladder cancer in a regional hospital

Cited by 4 publications

References 17 publications

Incidental gallbladder carcinoma in laparoscopic cholecystectomy: Five years local experience

Incidental gallbladder carcinoma in laparoscopic cholecystectomy: Five years local experience

Xanthogranulomatous cholecystitis: a European and global perspective

Risk and Cost-effectiveness of Surveillance Followed by Cholecystectomy for Gallbladder Polyps

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