Gallbladder cancer in Africa: A higher than expected rate in a “low-risk” population

Khan, Zafar Ahmed; Khan, Muhammed Uzayr; Brand, Martin

doi:10.1016/j.surg.2021.09.016

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…In South Africa, there were 574 histologically confirmed new cases and 287 deaths in 2018 [ 7 ]. However, a recent study evaluating records from 2003 to 2015 has suggested that there is a higher incidence of GBC in South Africa [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Proteomic analysis identifies dysregulated proteins and associated molecular pathways in a cohort of gallbladder cancer patients of African ancestry

et al. 2023

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Background Gallbladder cancer (GBC) is a lethal cancer with a poor prognosis. The lack of specific and sensitive biomarkers results in delayed diagnosis with most patients presenting at late stages of the disease. Furthermore, there is little known about the molecular mechanisms associated with GBC, especially in patients of African ancestry. This study aimed to determine dysregulated proteins in South African GBC patients to identify potential mechanisms of the disease progression and plausible biomarkers. Methods Tissues (27 GBC, 13 Gallstone disease, and 5 normal tissues) and blood plasma (54 GBC and 73 Benign biliary pathology) were obtained from consenting patients. Protein extraction was performed on all tissues and liquid chromatography-mass spectrometry was used for proteomic profiling. A project-specific spectral library was built using the Pulsar search algorithm. Principal component and Spearman’s rank correlation analyses were performed using PAST (V4.07b). Pathway and Network analyses were conducted using REACTOME (v3.7) and stringAPP (v1.7.0), respectively. Results In the tissue sample group, there were 62 and 194 dysregulated proteins in GBC compared to normal and gallstone groups, respectively. In the plasma group, there were 33 altered proteins in GBC compared to the benign biliary pathology group. We found 9 proteins (APOA1, APOA2, RET4, TTR, HEMO, HBB, HBA, PIGR, and APOE) to be commonly dysregulated in both tissue and plasma. Furthermore, a subset analysis demonstrated that 2 proteins, S100A8 and S100A9, were downregulated in GBC patients with GD history compared to those without. Pathway analysis showed that the dysregulated proteins in GBC patients were enriched in pathways involved in smooth muscle contraction, metabolism, ECM organization, and integrin cell surface interactions. Conclusion The identified dysregulated proteins help in understanding GBC molecular mechanisms in our patient group. Furthermore, the alteration of specific proteins in both tissue and plasma samples suggests their potential utility as biomarkers of GBC in this sample cohort.

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Section: Introductionmentioning

confidence: 99%

Proteomic analysis identifies dysregulated proteins and associated molecular pathways in a cohort of gallbladder cancer patients of African ancestry

et al. 2023

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“…[4–7] In addition, its incidence is relatively high, with a significant geographic variation. [8–13] The most frequent risk factors associated with GBC are cholelithiasis, [14] sex, age, obesity, [15] occupation, [16,17] chronic gallbladder inflammation, [18] and genetic predisposition. [19,20]…”

Section: Introductionmentioning

confidence: 99%

“…[4][5][6][7] In addition, its incidence is relatively high, with a significant geographic variation. [8][9][10][11][12][13] The most frequent risk factors associated with GBC are cholelithiasis, [14] sex, age, obesity, [15] occupation, [16,17] chronic gallbladder inflammation, [18] and genetic predisposition. [19,20] Previous studies have reported that complete surgical resection is one of the most effective modalities for patients with GBC.…”

Section: Introductionmentioning

confidence: 99%

Target nursing care on anxiety and depression in patients with gallbladder cancer during perioperative period

Liu¹,

Zhang²,

Guan³

et al. 2022

Medicine

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Background: This study retrospectively investigated the effects of target nursing care (TNC) on anxiety and depression in patients with gallbladder cancer (GBC) during the perioperative period.Methods: This retrospective study analyzed the data of 80 patients with GBC during perioperative period. These records were divided into an intervention group (n = 40) or a control group (n = 40). All 80 patient records in both groups were administered routine nursing care (RNC). The patients in the intervention group also underwent TNC. The primary outcomes were depression (measured using the Hamilton Depression Scale, HAMD) and anxiety (assessed using the Hamilton Anxiety Scale, HAMA). The secondary outcomes were quality of life (assessed using the 36-Item Short Form Health Survey, SF-36) and adverse events. We collected and analyzed the outcome data before and after treatment.Results: After treatment, patients in the intervention group showed more promising effects on depression (HAMD, P < .01) and anxiety (HAMA, P < .01) than those in the control group did. However, there were no significant differences in the quality of life before and after treatment. No TNC-or RNC-associated adverse events were reported in patient records.Conclusion: This study found that TNC was more effective than RNC in relieving depression and anxiety. Future studies should be conducted to validate the present findings.

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Can the sampling method affect the detection of incidental gallbladder carcinoma? Comparative analysis of two sampling methods

Hacıhasanoğlu

Paşaoğlu

Cin³

et al. 2023

Annals of Diagnostic Pathology

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Gallbladder cancer in Africa: A higher than expected rate in a “low-risk” population

Cited by 4 publications

References 15 publications

Proteomic analysis identifies dysregulated proteins and associated molecular pathways in a cohort of gallbladder cancer patients of African ancestry

Proteomic analysis identifies dysregulated proteins and associated molecular pathways in a cohort of gallbladder cancer patients of African ancestry

Target nursing care on anxiety and depression in patients with gallbladder cancer during perioperative period

Can the sampling method affect the detection of incidental gallbladder carcinoma? Comparative analysis of two sampling methods

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