Gallbladder cancer in Eastern Province of Saudi Arabia: A retrospective cohort study

Aldossary, Mohammed Yousef; Alayed, Amal A.; Amr, Samir S.; Alqahtani, Shareef; Alnahawi, Mamdouh; Alqahtani, Mohammed Saad

doi:10.1016/j.amsu.2018.09.020

Cited by 10 publications

(10 citation statements)

References 46 publications

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“…They also found that 75% of GBC Saudi patients had gallstones, which is a significant risk factor for GBC. 27 These findings may support our results that GBC is a significant type of cancer in the Eastern region of Saudi Arabia, which contributes to the increase of overall ASIR from 2004 to 2015. These studies also suggest reasons why the results of this study indicated the highest overall incidence of GBC among male and female Saudis were recorded in Riyadh and the Eastern province of Saudi Arabia.…”

Section: Discussionsupporting

confidence: 89%

“…25 The highest prevalence of obesity in Saudi Arabia is thought to be in Riyadh at 35%, while the rate of diabetes in Riyadh among males and females is 20 times greater than in Jazan. 26 In the Eastern region of Saudi Arabia, Aldossary et al 27 reported that 50% of GBC Saudi patients had diabetes and hypertension. They also found that 75% of GBC Saudi patients had gallstones, which is a significant risk factor for GBC.…”

Section: Discussionmentioning

confidence: 99%

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<p>Epidemiology of Gallbladder Cancer in Saudi Arabia</p>

Alqahtani

Alghamdi

2020

CMAR

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Background: Gallbladder cancer is generally rare but can be more common in some populations. The aim of this study was to present an analysis of gallbladder cancer epidemiology in Saudi Arabia. Materials and Methods: A retrospective study of gallbladder cancer cases in Saudi Arabia from 2004 to 2015 was conducted. The gallbladder cancer data were accessed through the Saudi Cancer Registry (SCR) reports for 13 administrative regions. The number of gallbladder cancer cases with percentage, the crude incidence rate (CIR) and the agestandardised incidence rate (ASIR), stratified by regions, gender, and the years of diagnoses were analysed. Results: A total of 1678 gallbladder cancer cases, 702 in males and 976 in females, were registered between 2004 and 2015. Saudi women and men in the 75 and above age-group were found to have the highest diagnosis rate of gallbladder cancer. In males, the overall ASIR among Saudi males was 1.1 per 100,000 (95% CI, 0.9 to 1.2). The Eastern region had the highest overall ASIR at 1.5 per 100,000 males, followed by Tabuk and Riyadh at 1.4 and 1.3 higher than other regions (F(12,143)=1.930, P<0.001). The overall ASIR among Saudi females was 1.6 per 100,000 (95% CI, 1.4 to 1.7). Riyadh had the highest overall ASIR at 2.4 per 100,000 females, followed by the Eastern region, and Qassim at 1.9 and 1.5, respectively, all higher than other provinces of the country (F(12,143)=2.496, P<0.005). The ASIR and CIR were lower among males than females (ratio 0.7). Conclusion: Gallbladder cancer incidence is relatively low in Saudi Arabia. The rates were higher in females than males. ASIR showed variations between different provinces of Saudi Arabia. In females, the highest ASIR was in Riyadh. In males, ASIR was highest in the Eastern region of Saudi Arabia.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

<p>Epidemiology of Gallbladder Cancer in Saudi Arabia</p>

Alqahtani

Alghamdi

2020

CMAR

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“…Our reversed ratio (about 1:3) mirrors the population profile in Qatar (21% females, 79% males) [3]. Although our number of GC cases among Qataris was small (3 patients), yet it comprised 2 females and 1 male, agreeing with the gender ratio seen worldwide, and also in line with that of other Middle Eastern countries (Jordan) where the ratios ranged between 3:2 and 3.7:1, and with Saudi Arabia where females comprsied 62% of the GC patients [[15], [16], [17]]. .…”

Section: Discussionsupporting

confidence: 77%

“…Our patients were also younger than those reported from other neighboring countries e.g. Saudi Arabia, where most patients were 66–70 years old [17]. The reasons behind our younger age patients are difficult to speculate, but demographic and ethnic factors might play a role.…”

Section: Discussionmentioning

confidence: 50%

Gallbladder cancer: 7-Year experience from Qatar

Sulieman

Elmoghazy

Ansari

et al. 2019

Annals of Medicine and Surgery

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Background Gallbladder cancer (GC) is a relatively rare disease. To date, there are no studies describing the epidemiology of this disease in Qatar. Objective To study the epidemiology of Gallbladder Cancer in Qatar. Methods A retrospective analysis of the cases of GC in Hamad General Hospital in Qatar from 2009 to 2016. Results Thirty-five patients presented with GC during the study period, 10 females (28.6%) and 25 males (71.4%). Fourteen patients (40%) were diagnosed incidentally after laparoscopic cholecystectomy, 16 (48.6%) were diagnosed pathologically, and 4 (11.4%) were diagnosed radiologically. The median age at diagnosis was 54 years (31–78). 74.3% of the disease occurred in patients less than 60 years old. Metastatic disease was discovered in 25 patients (71.4%) versus no metastasis in 10 patients (28.6%). The most common sites for metastasis were the liver (42.9%), peritoneum (25.7%), and lymph nodes (25.7%). Curative central hepatic resection was done in 8 patients (22.9%). Pathology showed adenocarcinoma in 27 patients (77.1%), neuroendocrine tumor in 3 patients (8.6%) and high-grade dysplasia in 1 patient (2.9%). No histopathology was available for 4 patients (11.4%). Twenty-eight patients (80.0%) had regular follow up, with 22 (62.9%) still alive. Six patients (17.1%) died during follow up with survival after diagnosis ranging from 42 days to 6.8 years. Conclusions In Qatar, due to the unique demographics, GC is more common in males and younger age groups. Most of the patients present late with metastasis, but curative resection is associated with long-term survival.

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“…Many publications report different mean ages for GBC. Besides, the mean age was reported to be 62.4 years in the study of Aldossary et al and 52.4 years in the study conducted by Charfi et al [8][9][10]. The mean age varies depending on regions and the number of cases in the study population.…”

Section: Discussionmentioning

confidence: 82%

Analysis of Incidental Gallbladder Cancer in Cholecystectomies

Kanlıöz¹,

Ekici

Ayva

2019

Cureus

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Objective: To study incidental gallbladder cancer (IGBC) incidence in patients who underwent cholecystectomy. Methods: The records of patients who underwent cholecystectomy between 2004-2019 were retrospectively reviewed. The demographic information, preoperative radiological findings of the patients diagnosed with gallbladder cancer (GBC), as a result of routine histopathological examination and operation records, were reviewed and findings were recorded. The preoperative radiological records of the patients with GBC and, if any, findings of GBC suspected during surgery were recorded. Results: Between 2004-2019, a total of 6314 patients underwent cholecystectomy. Of the patients, 5404 (85.59%) were female and 910 (14.41%) were male. The median age was 47 years (min:19, max:94) and the mean age was 47.28±14.60 years. Nine out of 6314 patients (0.14%) were diagnosed with GBC by postoperative histopathological examination. All patients with GBC were female and their mean age was 64.33±11.08 years. Two out of nine GBC cases were prediagnosed with GBC in preoperative radiological findings; the remaining seven (0.11%) had IGBC without any preoperative findings. Conclusion: Asian populations are reported to have a higher incidence of GBC. Turkey is located in the transition zone between Asia and Europe. However, the GBC rates in our study remain far below the rates reported in Asian publications. We believe that our results may be affected by the predominantly Mediterranean-type diet and the relatively higher socioeconomic level of the region where we conducted our study. Consequently, we recommend routine histopathological examination after cholecystectomies in regions with a high incidence of GBC.

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Gallbladder cancer in Eastern Province of Saudi Arabia: A retrospective cohort study

Cited by 10 publications

References 46 publications

<p>Epidemiology of Gallbladder Cancer in Saudi Arabia</p>

<p>Epidemiology of Gallbladder Cancer in Saudi Arabia</p>

Gallbladder cancer: 7-Year experience from Qatar

Analysis of Incidental Gallbladder Cancer in Cholecystectomies

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