Gallbladder cancer presenting with acute cholecystitis: a population-based study

Lam, Chi‐Ming; Yuen, Albert; Wai, Abraham Ka Chung; Leung, Rachel; Lee, A. Y.; Ng, Kelvin K.; Fan, Sheung Tat

doi:10.1007/s00464-004-9116-2

Cited by 51 publications

(39 citation statements)

References 8 publications

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“…The risk of gallbladder cancer is approximately 4-5 times higher in patients with gallstones than without gallstones, especially in susceptible populations such as the natives of South and North America and the Maori population of New Zealand [123]. A retrospective analysis by Lam and coworkers [124] concluded an increase in gallbladder cancer presenting with acute cholecystitis to be higher when compared with the same finding in patients undergoing elective cholecystectomy for cholelithiasis. Not only can an untreated case of cholelithiasis present clinically with the recurrence of the same symptoms, leading to chronic cholecystitis, but it can also lead to a variety of other complications, the most common being acute cholecystitis, acute pancreatitis, ascending cholangitis, and gangrenous gallbladder [125].…”

Section: Complicationsmentioning

confidence: 96%

Reactive Oxygen Species and the Hypomotility of the Gall Bladder as Targets for the Treatment of Gallstones with Melatonin: A Review

et al. 2008

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Free radical-mediated damage of the gall bladder epithelium predisposes to the development of both gall bladder inflammation and gallstone formation, which often coexist. Melatonin, a pineal and gut secretory product, due to its antioxidant activity along with its effect on the aging gall bladder myocytes, inhibits gallstone formation. Melatonin reduces the biliary levels of cholesterol by inhibiting cholesterol absorption across the intestinal epithelium and by increasing the conversion of cholesterol to bile acids. The incidence of gallstones is increasing and is expected to rise dramatically with the increase in the longevity and the risk factors such as obesity. The change in the prevalence of cholelithiasis is associated with a proportionate rise in the incidence of cholangiocarcinoma. In an attempt to improve the quality of life of the rapidly increasing aging population, this article reviews up-to-date information on the pathophysiology of the gall bladder function and discusses the development of new therapies with potential good patient compliance and lower cost than the current treatments.

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Section: Complicationsmentioning

confidence: 96%

Reactive Oxygen Species and the Hypomotility of the Gall Bladder as Targets for the Treatment of Gallstones with Melatonin: A Review

et al. 2008

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“…Currently, there are more studies that have began to focus on UGC [24,25] , but early diagnosis of gallbladder carcinoma is still difficult [26][27][28][29][30] . In order to improve the diagnosis of gallbladder carcinoma, epidemiological and clinicopathological studies should be conducted.…”

Section: Discussionmentioning

confidence: 99%

A clinicopathological analysis in unsuspected gallbladder carcinoma: A report of 23 cases

Zou²

2007

WJG

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AIM:To study the clinicopathological characteristics of unsuspected gallbladder carcinoma (UGC). METHODS:We retrospectively studied 23 cases of UGC in Tongji Hospital, and compared their clinicopathological characteristics with 33 cases of preoperatively diagnosed gallbladder carcinoma (PDGC). RESULTS:The proportion of UGC coexisting with cholecystolithiasis was significantly higher than that of PDGC (χ 2 = 13.53, P < 0.01). The infection rate of hepatitis B virus was 21.74% (5/23) in UGC and 30.30% (10/33) in PDGC. Nine (39.13%) of 23 patients with UGC and 8/33 (24.24) PDGC had contact with schistosome pestilent water. The rate of multiple pregnancies was 56.52% (13/23) in the patients with UGC and 42.42% (14/33) in PDGC. The primary location of the UGC was mostly in the neck and body of the gallbladder, and that of the PDGC was often in the body and bottom. The incidence of Nevin stageⅠand Ⅱ UGC was significantly higher than that of PDGC (χ 2 = 4.44, P < 0.05 and χ 2 = 4.96, P < 0.05) while that of Nevin stage Ⅴ UGC was significantly lower than that of PDGC (χ 2 = 7.59, P < 0.01).According to the grading of carcinoma, the incidence of well-differentiated UGC was significantly higher than that of PDGC (χ 2 = 4.16, P < 0.05), and that of poorlydifferentiated UGC was significantly lower than that of PDGC (χ 2 = 4.48, P < 0.05). CONCLUSION:There are different characteristics between UGC and PDGC, such as in primary location, malignant degree and incidence of coexistence with cholecystolithiasis. Cholecystolithiasis, hepatitis B, schistosome and multiple pregnancies were high risk factors for gallbladder carcinoma.

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“…Wang et al (2012) observed that early diagnosis and timely radical surgery are directly correlated to the prognosis of the patients. Incidental detection of gall bladder cancer in cholecystectomy specimen do has been reported in 0.3-2% of all cholecystectomy performed for benign conditions (Lam et al, 2005;Sun et al 2005;Misra et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Impact of Routine Histopathological Examination of Gall Bladder Specimens on Early Detection of Malignancy - A Study of 4,115 Cholecystectomy Specimens

Kalita

Pant²,

Singh³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Gallbladder cancer presenting with acute cholecystitis: a population-based study

Cited by 51 publications

References 8 publications

Reactive Oxygen Species and the Hypomotility of the Gall Bladder as Targets for the Treatment of Gallstones with Melatonin: A Review

Reactive Oxygen Species and the Hypomotility of the Gall Bladder as Targets for the Treatment of Gallstones with Melatonin: A Review

A clinicopathological analysis in unsuspected gallbladder carcinoma: A report of 23 cases

Impact of Routine Histopathological Examination of Gall Bladder Specimens on Early Detection of Malignancy - A Study of 4,115 Cholecystectomy Specimens

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