Gallbladder Cancer: The Role of Laparoscopy and Radical Resection

Singh, Sapna; Agarwal, Anil

doi:10.1097/sla.0b013e3181b490d9

Cited by 7 publications

(3 citation statements)

References 9 publications

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“…Clinically, most gallbladder polyps are benign, and only a minority are malignant polyps. Unfortunately, the prognosis and clinical management of them are quite different (3)(4)(5). Thus, it is crucial to differentiate benign and malignant GPs preoperatively.…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of a Preoperative Nomogram for Predicting Benign and Malignant Gallbladder Polypoid Lesions

Han

Liu

et al. 2022

Front. Oncol.

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PurposeThe purpose of this study was to develop and validate a preoperative nomogram of differentiating benign and malignant gallbladder polypoid lesions (GPs) combining clinical and radiomics features.MethodsThe clinical and imaging data of 195 GPs patients which were confirmed by pathology from April 2014 to May 2021 were reviewed. All patients were randomly divided into the training and testing cohorts. Radiomics features based on 3 sequences of contrast-enhanced computed tomography were extracted by the Pyradiomics package in python, and the nomogram further combined with clinical parameters was established by multiple logistic regression. The performance of the nomogram was evaluated by discrimination and calibration.ResultsAmong 195 GPs patients, 132 patients were pathologically benign, and 63 patients were malignant. To differentiate benign and malignant GPs, the combined model achieved an area under the curve (AUC) of 0.950 as compared to the radiomics model and clinical model with AUC of 0.929 and 0.925 in the training cohort, respectively. Further validation showed that the combined model contributes to better sensitivity and specificity in the training and testing cohorts by the same cutoff value, although the clinical model had an AUC of 0.943, which was higher than 0.942 of the combined model in the testing cohort.ConclusionThis study develops a nomogram based on the clinical and radiomics features for the highly effective differentiation and prediction of benign and malignant GPs before surgery.

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Section: Introductionmentioning

confidence: 99%

Development and Validation of a Preoperative Nomogram for Predicting Benign and Malignant Gallbladder Polypoid Lesions

Han

Liu

et al. 2022

Front. Oncol.

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“…However, due to the rapid growth of the tumor and the rarity of IGBC, the management of IGBC is still difficult and no clear guidelines have been well established. Based on current literature, there is a consensus among hepatobiliary surgeons that radical second resection should be performed in patients with IGBC with T2 or more advanced tumors [8][9][10]; however, radical second resection for management of T1b carcinomas is still discussed controversially [11,12]. Complete surgical resection of tumor is the only potential curative treatment option for patients with IGBC; however, patients received curative resection, and many of them showed poor outcome due to high recurrence rate [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Surgical Treatment of Incidental Gallbladder Cancer Discovered During or Following Laparoscopic Cholecystectomy

Tian

Liu

et al. 2014

World j. surg.

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Simple LC is appropriate for T1a patients with clear margin and unbroken gallbladder, whereas extended radical resection is recommended for patients with T1b or more advanced IGBC. An intact surgical specimen and the use of plastic retrieval bags are important to reduce the risk of port-site recurrences and disease relapse. Early diagnosis, meticulous perioperative assessment, and precise surgery are essential factors to obtain good results in IGBC treatment.

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“…IGBC is typically associated with a more favorable prognosis than non‐IGBC, as most cases of IGBC are diagnosed at an early stage 21‐23 . Patients with IGBC can, however, have poor long‐term outcomes and are susceptible to recurrence and disease‐specific death.…”

Section: Discussionmentioning

confidence: 99%

Identification of patients who may benefit the most from adjuvant chemotherapy following resection of incidental gallbladder carcinoma

Xiang

Zhang

Weber

et al. 2021

Journal of Surgical Oncology

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Background To develop a scoring system to identify the subset of patients who may benefit the most from adjuvant chemotherapy following curative‐intent resection for incidental gallbladder cancer (IGBC). Methods A novel scoring system was utilized to stratify patients relative to overall survival (OS), as well as potential benefit from adjuvant chemotherapy following curative resection for IGBC. Results Among 266 patients with IGBC, a total of 99 (37.2%) patients received adjuvant chemotherapy. Five risk factors were used to develop an integer‐based score to predict OS. Risk of death at 5‐years incrementally increased among patients in the low (n = 42, 69.0%), medium (n = 64, 56.3%) and high‐risk groups (n = 40, 30.0%) (median OS, 99.4 vs. 33.5 vs. 15.6 months, all p < .001). Use of adjuvant chemotherapy did not provide a survival benefit among patients in the low‐risk group (median survival, 99.4 vs. 60.7 months, p = .56). In contrast, utilization of adjuvant chemotherapy was associated with an improvement in survival among medium‐ (median survival, 21.7 vs. 59.5 months, p = .04) and high‐risk patients (median survival, 11.6 vs. 20.1 months, p = .01). Conclusions While low‐risk patients did not benefit from adjuvant chemotherapy, individuals with medium or high‐risk scores had an improved survival with the utilization of adjuvant chemotherapy.

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Gallbladder Cancer: The Role of Laparoscopy and Radical Resection

Abstract: REFERENCE 1. Shih SP, Schulick RD, Cameron JL, et al. Gallbladder cancer. The role of laparoscopy and radical resection. Ann Surg. 2007;245:893-901.

Cited by 7 publications

References 9 publications

Development and Validation of a Preoperative Nomogram for Predicting Benign and Malignant Gallbladder Polypoid Lesions

Development and Validation of a Preoperative Nomogram for Predicting Benign and Malignant Gallbladder Polypoid Lesions

Surgical Treatment of Incidental Gallbladder Cancer Discovered During or Following Laparoscopic Cholecystectomy

Identification of patients who may benefit the most from adjuvant chemotherapy following resection of incidental gallbladder carcinoma

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