Gallbladder cancers

Cariati, Andrea; Piromalli, Elisa; Cetta, Francesco

doi:10.1097/meg.0000000000000074

Cited by 49 publications

(18 citation statements)

References 32 publications

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“…This geographic variability is most likely attributable to differences in environmental exposures and a regional intrinsic predisposition to carcinogenesis [ 7 ]. This genetic predisposition is proposed to originate from population migration patterns in Central Asia/Himalayas through Bering Strait during the last glacial era [ 12 ]. However, though such patterns of prevalence are observed, there is no true unifying factor that explains this unusual geographic distribution.…”

Section: Epidemiology and Risk Factorsmentioning

confidence: 99%

“…Patients at high risk (stones >2-3 cm, associated polyps, nonfunctioning gallbladder, porcelain gallbladder, pancreaticobiliary reflux, segmental adenomyomatosis, and xanthogranulomatous cholecystitis) may significantly benefit from prophylactic cholecystectomy, particularly those in a high risk geographical location [ 3 , 12 ]. It is also recommended that gastrectomy patients undergo a concomitant cholecystectomy as these patients are predisposed to delayed gastric emptying with increased incidence of gallstones and rarely gallbladder cancers [ 12 ]. Potentially, unnecessary patient morbidity and the increased cost however remain barriers to this practice.…”

Section: Prognosismentioning

confidence: 99%

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Gallbladder Cancer in the 21st Century

Kanthan

Senger

Ahmed

et al. 2015

Journal of Oncology

254

241

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Gallbladder cancer (GBC) is an uncommon disease in the majority of the world despite being the most common and aggressive malignancy of the biliary tree. Early diagnosis is essential for improved prognosis; however, indolent and nonspecific clinical presentations with a paucity of pathognomonic/predictive radiological features often preclude accurate identification of GBC at an early stage. As such, GBC remains a highly lethal disease, with only 10% of all patients presenting at a stage amenable to surgical resection. Among this select population, continued improvements in survival during the 21st century are attributable to aggressive radical surgery with improved surgical techniques. This paper reviews the current available literature of the 21st century on PubMed and Medline to provide a detailed summary of the epidemiology and risk factors, pathogenesis, clinical presentation, radiology, pathology, management, and prognosis of GBC.

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Section: Epidemiology and Risk Factorsmentioning

confidence: 99%

Section: Prognosismentioning

confidence: 99%

Gallbladder Cancer in the 21st Century

Kanthan

Senger

Ahmed

et al. 2015

Journal of Oncology

254

241

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“…Cystic duct adenocarcinoma is a rare entity, and is considered a GB cancer [ 7 ]. Although the risk factors of GB cancer are being reported, those of cystic duct adenocarcinoma were reported nil [ 8 ]. Cystic duct adenocarcinoma is reported that it accounts for 8% of the entire GB cancer [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

Adenocarcinoma developed from remnant cystic duct after cholecystectomy

Hyuk

Choi

2014

BMC Gastroenterol

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BackgroundCystic duct adenocarcinoma is a rare disease because the cystic duct has a short length and a narrow cavity. Cystic duct adenocarcinoma accounts for 8% of all gallbladder adenocarcinoma; of these, adenocarcinoma that develops from the remnant cystic duct after cholecystectomy is extremely rare. We report a case of incidentally detected adenocarcinoma that developed from the remnant cystic duct in a patient with history of cholecystectomy.Case presentationA 74-year-old Korean woman visited our hospital with abdominal pain. Her past medical history included cholecystectomy for acute cholecystitis with gallstones 10 years previously. Imaging of the abdomen demonstrated inflammation of the remnant cystic duct with multiple impacted stones. Complete removal of the remnant cystic duct with stones was performed. The pathologic report showed severe inflammation with abscess formation and an unexpected adenocarcinoma that appeared to invade the perimuscular connective tissue. The second operation (confirmation of the resection margin of the remnant cystic duct, wedge resection of the liver, and lymphadenectomy) was performed due to suspicion of pT2. There were no cancer cells in the resection margin of the remnant cystic duct, liver, or lymph nodes (0/6). The final histopathological diagnosis was pT2N0M0. She recovered without any complications. The patient is still living 1 year after surgery without recurrence or metastasis.ConclusionsWe report a rare case of adenocarcinoma that developed from the remnant cystic duct in a patient who underwent cholecystectomy.

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“…According to epidemiologic studies, gallstones represent the most important risk factor for GbCa, being present in as many as 96% of patients [8]. Indeed, rates of GbCa increase with the prevalence of gallstone disease, which more commonly affects certain indigenous populations, particularly in North and South America.…”

Section: Environmental Risk Factors For Gallbladder Cancermentioning

confidence: 99%

“…Apart from gallstones, obesity, inflammation in bile ducts, typhoid, salmonella and, to a lesser extent, Helicobacter infections, chronic cholecystitis, gallbladder polyps and female gender are regarded as risk factors for GbCa (Table I) [8,[25][26][27][28][29]. Presence of chronic inflammation is considered as another predisposing factor for gallbladder malignancies.…”

Section: Environmental Risk Factors For Gallbladder Cancermentioning

confidence: 99%

Modifiable Factors and Genetic Predisposition Associated with Gallbladder Cancer. A Concise Review

Liebe

Milkiewicz

Krawczyk

et al. 2015

JGLD

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Gallbladder cancer (GbCa) is the most frequent malignancy of the biliary tract. It is also the 6th most common gastrointestinal tumor. It is associated with very high lethality, mainly due to the lack of symptoms up to a very late and thus incurable state. As many as 80% of patients are diagnosed at very late stages of disease, which allow only palliative therapy. As a result, most of the patients with GbCa will die within 6 months of the diagnosis, hence the average 5-year survival does not exceed 5%. Currently, surgical resection represents the only curative option in GbCa, but this approach is feasible only at an early stage of the disease. Other oncologic therapies are of limited use. The incidence of GbCa is remarkably increased in certain populations such as Native North Americans, South Indian females and, in Europe, in the Polish population. It is not clear to date if these enhanced risk populations are the result of common environmental exposure or of shared genetic risk factors. In this review we provide an overview of the state-of-art in GbCa research with the focus on the current knowledge concerning genetic and environmental triggers of this tumor.

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Gallbladder cancers

Cited by 49 publications

References 32 publications

Gallbladder Cancer in the 21st Century

Gallbladder Cancer in the 21st Century

Adenocarcinoma developed from remnant cystic duct after cholecystectomy

Modifiable Factors and Genetic Predisposition Associated with Gallbladder Cancer. A Concise Review

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