Gallbladder carcinoma: An analysis of the national cancer data base to examine hispanic influence

Liu, Chrissy; Berger, Nicholas G.; Rein, Lisa; Tarima, Sergey; Clarke, Callisia N.; Mogal, Harveshp; Christians, Kathleen K.; Tsai, Susan; Gamblin, T. Clark

doi:10.1002/jso.25050

Cited by 5 publications

(2 citation statements)

References 20 publications

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“…Previously, a National Cancer Database (NCDB) study analyzing the impact of Hispanic race/ethnicity on OS suggested that survival outcomes were better at ACCs vs CCCs in treatment of GBC 6 . However, this study was not propensity matched to account for imbalance among demographics and clinical pathologic traits.…”

Section: Introductionmentioning

confidence: 99%

Comparison of overall survival in gallbladder carcinoma at academic versus community cancer centers: An analysis of the National Cancer Data Base

Liu

Rein

Clarke

et al. 2020

Journal of Surgical Oncology

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Background and Objectives Gallbladder carcinoma (GBC) has a poor prognosis. Studies demonstrated that teaching facilities may provide a lower risk of mortality in patients undergoing pancreatic and colon resection vs nonteaching facilities. We hypothesized that survival rates are higher in academic cancer centers (ACCs) vs community cancer centers (CCCs). Methods Patients with all stages of GBC were identified from the National Cancer Database (2007‐2012). Propensity score matching adjusted for selection bias. Descriptive statistics were calculated for all variables. Overall survival (OS) was compared by facility type (ACC vs CCC) and case volume (low vs high) via multivariable Cox proportional hazards regression. Results A total of 7967 patients met the inclusion criteria. Following propensity matching, 2801 patients were analyzed from each facility type. Median OS following surgery was higher for ACC (20.99 months, 95% confidence interval [CI], 19.61‐22.64, P = .002) than CCC (17.68 months, 95% CI, 16.46‐19.25). Following Cox modeling, GBC treatment at ACCs was a protective factor for OS (adjusted hazard ratio 0.876, 95% CI, 0.801‐0.958, P = .004). Discussion GBC treatment at ACCs is an independent predictor of OS. High volume ACCs are associated with improved OS compared with low volume ACCs. The site of care and case volume in ACCs may contribute to improved survival outcomes.

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Section: Introductionmentioning

confidence: 99%

Comparison of overall survival in gallbladder carcinoma at academic versus community cancer centers: An analysis of the National Cancer Data Base

Liu

Rein

Clarke

et al. 2020

Journal of Surgical Oncology

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“…However, Japanese and Asian patients diagnosed with gastric cancer have been reported to have better overall survival compared to White patients [12]. For patients diagnosed with gallbladder cancer Hispanic ethnicity, although, showed better overall survival, but after adjusting for covariates such as treatment at an academic facility and year of diagnosis, this effect turned out to be non-signi cant [13]. Furthermore, it has also been reported that whites when compared to African Americans experienced better survival in small intestinal and anal cancer survival [14].…”

Section: Introductionmentioning

confidence: 96%

Gastrointestinal Cancers: Racial and Ethnicity Differences

Singh

Konduri

Datta

et al. 2021

Preprint

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Objective: The purpose of this study was to examine race and ethnicity for overall survival (OS) and percent survival after 5- and 10-years for patients diagnosed with one of the gastrointestinal (GI) cancers.Method: We used national data for 12 types of GI cancers (esophagus, stomach, gallbladder, intrahepatic bile duct, extrahepatic bile duct, liver, pancreas, small intestine, colon, rectosigmoid, rectum, and anal) for the years 2004-2016. Results: A total of 2,249,213 patients diagnosed with one of the GI tract cancers with median age of 67 years were included in this study. There were 55% male, 77% non-Hispanic White (NHW), 12% were non-Hispanic Black (NHB), 6% were Hispanic, and the rest were classified as ‘Other’ race (4%). OS was higher for the Hispanics, followed by the ‘Other’, NHW and NHB (P <0.001). After adjusting for sex, income, insurance status, grade differentiation, age, and for Charlson-Dayo index, Hispanics and ‘Other’ race category had lower mortality compared to NHW (HR=0.93, 0.92-0.94, p <0.001; HR=0.92, 0.91-0.93, p <0.001), whereas NHB had higher risk compared to NHW (HR=1.09,1.08-1.09 p <0.001). Hispanics had lower mortality than NHW for 11 or 12 types (except esophagus), and ‘Other’ race category had lower risk for 10 of 12 types (except anal and small intestine). Five- and 10-year survival rates were higher for Hispanic patients (47%, 36%) followed by ‘Other’ (42%, 31%), NHW (40%, 28%), and for NHB (38%, 28%).Conclusion: Hispanics and the patients from ‘Other’ race category diagnosed with one of the GI cancers had longer survival probability and lower risk of mortality compared to NHW and NHB.

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High-Quality Surgery for Gallbladder Carcinoma: Rare, Associated with Disparity, and Not Substitutable by Chemotherapy

Salehi

Vega

Mellado

et al. 2022

Journal of Gastrointestinal Surgery

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Gallbladder carcinoma: An analysis of the national cancer data base to examine hispanic influence

Abstract: Hispanic ethnicity exhibits the highest OS for GBC, but after adjusting for covariates, this influence is not significant.

Cited by 5 publications

References 20 publications

Comparison of overall survival in gallbladder carcinoma at academic versus community cancer centers: An analysis of the National Cancer Data Base

Comparison of overall survival in gallbladder carcinoma at academic versus community cancer centers: An analysis of the National Cancer Data Base

Gastrointestinal Cancers: Racial and Ethnicity Differences

High-Quality Surgery for Gallbladder Carcinoma: Rare, Associated with Disparity, and Not Substitutable by Chemotherapy

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