Gallbladder disease is associated with insulin resistance in a high risk Hispanic population

Nervi, Flavio; Miquel, Juan Francisco; Álvarez, Manuel; Ferreccio, Catterina; García-Zattera, María José; Gonzalez, Robinson G.; Pérez-Ayuso, Rosa María; Rigotti, Attilio; Villarroel, Luís

doi:10.1016/j.jhep.2006.01.026

Cited by 146 publications

(115 citation statements)

References 62 publications

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“…Moreover, NHANES III data collection avoids the ascertainment bias that occurs in studies using selected patients and allows for a better understanding of the relationships between gallstone disease, cholecystectomy, and NAFLD. An increased prevalence of NAFLD in GB disease has been found in several previous studies ( 16 -19 ), but only one of them grouped cholecystectomized subjects separated from gallstone patients, showing a tendency for a stronger association of NAFLD with cholecystectomized subjects as compared with gallstone patients ( 19 ). In another study, cholecystectomy, but not cholelithiasis, was associated with cirrhosis and elevated serum liver enzyme levels in a study based in the cross-sectional NHANES III survey ( 20 ).…”

mentioning

confidence: 76%

Editorial : Cholecystectomy and NAFLD: Does Gallbladder Removal Have Metabolic Consequences?

Nervi

Arrese

2013

American Journal of Gastroenterology

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Pathogenesis of nonalcoholic fatty liver (NAFLD) disease and gallbladder (GB) disease secondary to cholesterol gallstones is complex, yet both conditions share similar associated risk factors, most of them related to the metabolic syndrome. Cholecystectomy, the best treatment for GB disease, is one of the most performed abdominal surgeries worldwide. In this issue of the American Journal of Gastroenterology , Ruhl and Everhart, using data from the Third United States National Health and Nutrition Examination Survey (1988 -1994), show that NAFLD is associated with cholecystectomy (odds ratio (OR) = 2.4; 1.8 -3.3), but not with gallstones (OR = 1.1; 0.84 -1.4). This fi nding suggests that cholecystectomy may itself represent a risk factor for NAFLD, which is in line with the recently undisclosed role of the GB and bile acids in systemic metabolic regulation. Thus, cholecystectomy may not be innocuous and may have a major impact on public health by contributing to NAFLD development.

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confidence: 76%

Editorial : Cholecystectomy and NAFLD: Does Gallbladder Removal Have Metabolic Consequences?

Nervi

Arrese

2013

American Journal of Gastroenterology

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“…An extended form of endothelial pathophysiology in insulin-resistant states could be microalbuminuria (Rowley et al 2003). Insulin resistance is also associated with gall bladder disease (Nervi et al 2006). Bile is typically more lithogenic when it contains a higher cholesterol:bile acids and phospholipids.…”

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confidence: 99%

Mechanisms of the components of the metabolic syndrome that predispose to diabetes and atherosclerotic CVD

Eckel

2007

Proc. Nutr. Soc.

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The metabolic syndrome represents a summation of obesity-driven risk factors for atherosclerotic CVD and type 2 diabetes. Definitions of the syndrome vary but in general agree closely in identifying subjects. The relationships between the metabolic syndrome and atherosclerotic CVD and diabetes also vary, with relative risks of approximately 1 . 5-3 . 0 and approximately 3 . 0-5 . 0 respectively. Insulin resistance appears to explain much of the pathophysiology of the syndrome. Both increased fatty acid flux and an excess of circulating proinflammatory cytokines are likely mediators. With increased waist circumference, increases in fatty acid delivery to the liver result in higher rates of hepatic glucose production and increases in the secretion of apoB-containing lipoproteins. Concomitant changes in HDL ensue, including a replacement of the cholesterol content with TAG, an accelerated clearance from the plasma and thus a reduced number of HDL particles. Typically also present are increases in small dense LDL. Hypertension in part relates to the insulin resistance, but may involve other mechanisms. Impaired fasting glucose often relates to defects in insulin secretion in addition to insulin resistance, and probably more than any other component of the syndrome predicts the increased incidence of type 2 diabetes. Although not included in the diagnostic criteria, increases in pro-inflammatory cytokines and pro-thrombotic factors, in addition to decreases in plasma adiponectin, may also contribute to the increased incidence of atherosclerotic CVD and diabetes. In general, the greater the number of metabolic syndrome components, the greater the risk for these outcomes. The cytokines and pro-thrombotic factors also appear to contribute.

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“…Este riesgo incrementa drásticamente en función del envejecimiento e incremento en los niveles de obesidad de la población. Los resultados de este estudio entregan, por primera vez, información sistemática sobre la prevalencia de SM en la etnia Mapuche urbana y rural de nuestro país y ayuda a dimensionar el riesgo de enfermedades asociadas a SM, tales como ECVs, DM2, colelitiasis e hígado graso 28,29 , en nuestras poblaciones originarias y puede ser relevante para implementar políticas de salud pública orientadas a la prevención de estas enfermedades a nivel nacional en dicho grupo étnico.…”

Section: Discussionunclassified

Prevalencia de síndrome metabólico en individuos de etnia Mapuche residentes en zonas rurales y urbanas de Chile

Ibáñez

Sanzana

Salas³

et al. 2014

Rev. méd. Chile

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Gallbladder disease is associated with insulin resistance in a high risk Hispanic population

Cited by 146 publications

References 62 publications

Editorial : Cholecystectomy and NAFLD: Does Gallbladder Removal Have Metabolic Consequences?

Editorial : Cholecystectomy and NAFLD: Does Gallbladder Removal Have Metabolic Consequences?

Mechanisms of the components of the metabolic syndrome that predispose to diabetes and atherosclerotic CVD

Prevalencia de síndrome metabólico en individuos de etnia Mapuche residentes en zonas rurales y urbanas de Chile

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