Gallbladder metastasis of non-small cell lung cancer presenting as acute cholecystitis

Jeong, Yusook; Han, Hye‐Suk; Lim, Sung Cil; Kim, Mi Jin; Han, Joung-Ho; Kang, Minho; Ryu, Dong Hee; Lee, Ok-Jun; Lee, Ki-Hyeong; Kim, Seung-Taik

doi:10.1007/s11670-012-0249-x

Cited by 13 publications

(11 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most gallbladder metastases by lung cancer are often detected metachronously. GM from non-small cell lung cancer (NSCLC) can be frequently symptomatic presenting as acute cholecystitis [ 53 ]. This finding may be due to the aggressiveness of the primary tumor.…”

Section: Lung Cancermentioning

confidence: 99%

Imaging of gallbladder metastasis

et al. 2021

View full text Add to dashboard Cite

Gallbladder metastasis (GM) is a rare condition, often with a late diagnosis or detected upon autopsy. There is no extensive literature on the imaging diagnosis of GM. Here we present a comprehensive review of the literature with the aim of helping to interpret the clinical findings and imaging features of such patients. Few studies on GM are reported in literature. GM by melanoma accounts for about 55.6% of cases. The remaining cases origin from breast cancer (13.6%), hepatocellular carcinoma (13.6%), renal cell carcinoma (6.8%), lung cancer (4.5%), lymphoma (3.5%) and gastric cancer (2.4%). The most common clinical presentation of GM is abdominal pain from cholecystitis due to obstruction of the cystic duct. The main ultrasound (US), computed tomography (CT) and magnetic resonance imaging (MRI) findings that clinicians and radiologists should consider in their everyday medical activity were discussed. The diagnosis of GM was often achieved through a combination of more than one imaging modality. In more than 90% of cases, the diagnosis of GM is often late and combined with other organs involvement in the terminal stage of the malignancy. The knowledge of the clinical features and different imaging techniques through careful evaluation of the gallbladder can help to achieve early diagnosis and avoid misdiagnosis or false negative results.

show abstract

Section: Lung Cancermentioning

confidence: 99%

Imaging of gallbladder metastasis

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Uncommon metastases to the gallbladder include prostate carcinoma (Colombat et al 1999;Maxwell et al 2009), gastric carcinoma (Bellucci 1967;Bilici et al 2012), rectal carcinoma (Abacheril and Metzger 2008), squamous cell carcinoma of the lung (Jeong et al 2012), pulmonary large cell carcinoma (Tanaka et al 2009) and other non-small cell carcinomas of the lung (Nassenstein and Kissler 2004), osteoclast-like giant cell tumor of the pancreas (Sun et al 1998), carcinoma of the uterine cervix (Martinez-Roman et al 2005), medullary plasmocytoma (Schuster et al 2007), and perivascular epithelioid tumors (Sendo et al 2013). Similar to more common types of metastases, rare metastatic gallbladder neoplasms can also cause acute cholecystitis, e.g., carcinoma of the stomach (Bilici et al 2012).…”

Section: Rare Types Of Metastasesmentioning

confidence: 99%

Melanocytic, Neuroectodermal, Germ Cell, Rhabdoid, Perivascular Epithelioid Cell, Hemolymphatic, and Metastatic Tumors of the Gallbladder

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

View full text Add to dashboard Cite

The gallbladder is involved by a wide variety of non-epithelial tumors, apart from mesenchymal neoplasms. Visceral malignant melanoma develops in the biliary tract, including the gallbladder. As both primary and metastatic gallbladder melanomas may show similar of the same growth patterns, the differential diagnosis between these two conditions is often difficult. Primary gallbladder melanoma is more likely if the tumor shows a polypoid or lobulated and in particular papillary growth pattern, is a solitary lesion, and is associated with junctional activity in the adjacent mucosa. In contrast, metastatic lesions are more commonly multiple, flat, and without junctional changes. Apart from neuroendocrine tumors, other neuroectodermal neoplasms can develop as primary tumors in the gallbladder. Rare primary neoplasms in this organ include germ cell tumors, rhabdoid tumors, perivascular epithelioid cell tumors, and hemolymphatic neoplasms. Apart from malignant melanoma, numerous other malignancies can metastasize to the gallbladder, renal cell carcinoma being a particularly common metastasizing tumor. Malignant Melanoma of the Gallbladder Pathogenic Pathways Few melanocytes are present in the normal gallbladder mucosa, and it has been suggested that malignant melanomas take their origin from these cells that have spread from the neural crest to the gallbladder during oncogenesis. Primitive Neuroectodermal Tumor (PNET) of the Gallbladder Differential Diagnosis Differential diagnosis on conventionally stained sections mainly includes other small cell tumors occurring in the gallbladder, e.g., small cell carcinoma or lymphoma. Differential Diagnosis Gallbladder paraganglioma may occur as a component of multiple paragangliomas, involving the common bile duct and the liver in addition to the gallbladder (Ferrell et al. 1990).

show abstract

“…Such successful treatment outcomes of these small intestinal metastases may be attributable to the presence of only single intestinal lesions without abdominal lymph node involvement [ 1 , 8 ]. Reports of isolated gallbladder metastases from a primary lung cancer are even less common [ 9 , 10 ], and no report is available on the successful resection of both isolated small intestinal and gallbladder metastases via minimally invasive surgery.…”

Section: Case Presentationmentioning

confidence: 99%

Usefulness of immunohistochemical studies in diagnosing metachronous gallbladder and small intestinal metastases from lung cancer with gastrointestinal hemorrhage: a case report

et al. 2015

View full text Add to dashboard Cite

Isolated metachronous gastrointestinal metastases from advanced-stage lung cancer are rarely diagnosed on the basis of symptoms and resected. In this report, we present a case of resectable metachronous gallbladder and small intestinal metastases of lung cancer. An 86-year-old woman was treated for lung cancer with resection of the right inferior lobe. Five months after the surgery, she was re-admitted because of melena and anemia. Ultrasonography showed a gallbladder tumor with gastrointestinal hemorrhage, and laparoscopic-assisted cholecystectomy was subsequently performed. However, 2 months after this event, the patient presented again with melena and anemia and was diagnosed with a small intestinal tumor. Therefore, laparoscopic-assisted partial resection of the small intestine was performed. Immunohistochemical staining for thyroid transcription factor-1 and cytokeratin 7 confirmed that the two resected tumors were metachronous metastases of the primary lung cancer. The patient died of liver metastases 5 months after the last surgery. Our experience with this case suggests that surgical resection might not be curative but palliative for patients with isolated gallbladder and small intestinal metastases diagnosed on the basis of melena that is resistant to conservative treatment.

show abstract

Gallbladder metastasis of non-small cell lung cancer presenting as acute cholecystitis

Cited by 13 publications

References 13 publications

Imaging of gallbladder metastasis

Imaging of gallbladder metastasis

Melanocytic, Neuroectodermal, Germ Cell, Rhabdoid, Perivascular Epithelioid Cell, Hemolymphatic, and Metastatic Tumors of the Gallbladder

Usefulness of immunohistochemical studies in diagnosing metachronous gallbladder and small intestinal metastases from lung cancer with gastrointestinal hemorrhage: a case report

Contact Info

Product

Resources

About