Gallbladder pressure-volume response to gastrointestinal hormones

Ryan, J.F.; Cohen, Sidney

doi:10.1152/ajplegacy.1976.230.6.1461

Cited by 60 publications

(31 citation statements)

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“…Indeed, the nonlinear behaviour is shown in guinea-pig gallbladders (Ryan and Cohen 1976;Bertuzzi et al 1992). The work of (Bertuzzi et al 1992) further showed that such an effect can be significant in gallbladder wall.…”

Section: Introductionmentioning

confidence: 91%

Anisotropic behaviour of human gallbladder walls

Hill

Ogden

et al. 2013

Journal of the Mechanical Behavior of Biomedical Materials

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Inverse estimation of biomechanical parameters of soft tissues from non-invasive measurements has clinical significance in patient-specific modelling and disease diagnosis.In this paper, we propose a fully nonlinear approach to estimate the mechanical properties of the human gallbladder wall muscles from in vivo ultrasound images. The iteration method consists of a forward approach, in which the constitutive equation is based on a modified Hozapfel-Gasser-Ogden law initially developed for arteries. Five constitutive parameters describing the two orthogonal families of fibres and the matrix material are determined by comparing the computed displacements with medical images. The optimization process is carried out using the MATLAB toolbox, a Python code, and the ABAQUS solver. The proposed method is validated with published data in artery and subsequently applied to ten human gallbladder samples. Results show that the human gallbladder wall is anisotropic during passive refilling phase, and that the peak stress is 1.6 times greater than that calculated using the linear mechanics. This discrepancy arises because the wall thickness reduces by 1.6 times during the deformation, which is not predicted by conventional linear elasticity. If the change of wall thickness is accounted for, then the linear model can used to predict the gallbladder stress and its correlation with pain. This work provides further understanding of the nonlinear characteristics of human gallbladder.

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Section: Introductionmentioning

confidence: 91%

Anisotropic behaviour of human gallbladder walls

Hill

Ogden

et al. 2013

Journal of the Mechanical Behavior of Biomedical Materials

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“…25 It has been shown that the active stress of gallbladder smooth muscle due to a stimulus is highly time-dependent 7,56 and probably quite patient specific. 18 Even though the gallbladder pressure-volume response to various continuous intravenous infusions of CCK has been observed 42 and a dynamic method has been proposed for describing gallbladder tone in an in situ baboon model, 43 to date, very few studies have aimed at estimating the action stress in primate gallbladder smooth muscles.…”

Section: Introductionmentioning

confidence: 99%

A Mechanical Model for CCK-Induced Acalculous Gallbladder Pain

Luo

Hill

et al. 2010

Ann Biomed Eng

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Abstract-This study investigates the potential correlation between acalculous biliary pain and mechanical stress during the bile-emptying phase. This study is built on the previously developed mathematical model used to estimate stress in the gallbladder wall during emptying [Li, W. G., X. Y. Luo, et al. Comput. Math. Methods Med. 9(1):27-45, 2008]. Although the total stress was correctly predicted using the previous model, the contribution from patient-specific active stress induced by the cholecystokinin (CCK) test was overlooked. In this article, we evaluate both the active and passive components of pressure in a gallbladder, which undergoes isotonic refilling, isometric contraction and emptying during the infusion of CCK. The pressure is estimated from in vivo ultrasonographical scan measurements of gallbladder emptying during CCK tests, assuming that the gallbladder is a thin ellipsoidal membrane. The passive stress is caused by the volume and shape changes during refilling at the gallbladder basal pressure, whereas the active stress arises from the pressure rise during the isometric gallbladder contraction after the CCK infusion. The effect on the stress estimates of the gallbladder to the liver is evaluated to be small by comparing numerical simulations of a gallbladder model with and without a rigid 'flat top' boundary. The model was applied to 51 subjects, and the peak total stress was found to have a strong correlation with the pain stimulated by CCK, as measured by the patient pain score questionnaires. Consistent with our previous study for a smaller sample, it is found that the success rate in predicting of CCK-induced pain is over 75%.

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“…Ali these techniques are based on either perfusion of the gallbladder (85,86,87,89,90) This decrease was manifested by significant reductions in gallbladder contraction amplitude and integrated contraction, which IS a measure of both Ceruletlde is a decapeptide Isolated fram frog skin that has numerous structural similaritles with cholecystokinln(9). In certain animal models, ceruletide has been shown to be as much as ten times more pote nt th an cholecystokinin in inducing gallbladder contraction (9).…”

Section: Spontaneous Gallbladder Activitymentioning

confidence: 99%

“…There exist several in vitro and in vivo models for evaluatlng gallbladder contractility (4,83,84,85,86,87,88,89,90,91 Several invasive in vivo models have been described (83,84,87) Includlng sorne that allow for chronic studies (87,89). Ali these techniques are based on either perfusion of the gallbladder (85,86,87,89,90) Direct measurement of gallbladder tension utilizes simple equipment (83,88).…”

Section: Spontaneous Gallbladder Activitymentioning

confidence: 99%

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Nifedipine inhibits cholecystokinin-induced gallbladder contraction

Clas

Hould

Rosenthall

et al. 1989

Journal of Surgical Research

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MSc Surgery David Clas ExpenmentalNifedipine Inhibits Cholecystokinin-Induced Gallbladder Contraction.The pur pose of this study was to show that mfedlpine, a calcium channel blocker, can decrease:: gallbladder contractllity in gUlnea plgs and ln man The Importance of calcium fluxes ir smooth muscle contraction is weil reGognlzed. In contrast to the action potential of sk€letal muscle, the action potentlal of smooth muscl& IS calcium dependent.Nlfedlpine 13 one of a group of calcium channel blocklng drugs that has been used chnlcally ln the management of angina and hypertension. Calcium channel blockers cause their clinical effect by acting on the smooth muscle of the blood vessels. The entire gastrointestinal tract, including the gallbladder, contains smooth muscle. Although the use of nifedipine has been studied in the treatment of a vanety of gastrointestinal motlilty disturbances, its effect on gallbladder rTIotlhty has not yet been weil characterized.The purpose of this study was to Investigate, both in an in vivo animal model and in man, the effects of the calcium channel blocker nifedipine on the cholecystoklnln-Induced contraction of the gallbladder. We hypothesized that nlfedlpine dlmlnlshes gallbladder contractility. ThiS effect may be potentially useful chnlcally ln the management of bihary collc. As motility disorders of the gallbladder are Imphcated ln ga"stone formation, any decreased gallbladder motility due to calcium channel blockers used for other therapeutic purposes may cause galistonE? disease ln the many patients on these drugs.ln man, the gallbladder is a ~ollow pear shaped appendage of the extrahepatic biliary tree. It is found on the undereurface of the hver in a de pression on the right lObe. It 15 normally from 7 ta 1 0 cm long and 2 to 3 cm wide. The volume of the gallbladder vanes but is usually from 35 to 50 ml (3). The gallbladder is Il 1 l il divided into three regions, the fundus, the body, and the neck, whlch JOins tlle eystic duet and ultlmately combines wlth the eommon hepatlc duet ta form the common bile duct. The common bile duct JOins wlth the main pancreatlc duct to drain Into the duodenum This terminai segment IS known as the ampulla ofVater. It 13 surrounded by smooth muscle, the sphincter of Oddl Dehvery of bile mto the duodenum IS not only controlled by contraction of the gallbladder but also by the motlhty of the sphincter of Oddl (4) The gallbladder wall is composed of five layers, the innermost mucous layer, the lamina propna, the muscular layer whlch consists of Irregularly onented smooth muscle fibre bundles, the penmuscular connective tissue layer. and an outermost serous layer.The blood supply of the human gallbladder usually anses trom a single cystlc art~ry, a branch of the nght hepatlc arlery There are numerous anatomlc val iatlons whlch are of greater surglcal Importance than physlologlc significance. The organ also recelves blood dlrectly from the hepatlc surface of the liver. There IS no major cystlc vein Venous return runs elther directly to the liver or ...

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Gallbladder pressure-volume response to gastrointestinal hormones

Cited by 60 publications

References 0 publications

Anisotropic behaviour of human gallbladder walls

Anisotropic behaviour of human gallbladder walls

A Mechanical Model for CCK-Induced Acalculous Gallbladder Pain

Nifedipine inhibits cholecystokinin-induced gallbladder contraction

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