Gallbladder wall inflammatory cells in pediatric patients with biliary dyskinesia and cholelithiasis: a pilot study

Rau, Beate; Friesen, Craig A.; Daniel, J.; Qadeer, Adnan; You-Li, Ding; Roberts, Charles S.; Holcomb, George

doi:10.1016/j.jpedsurg.2006.05.015

Cited by 22 publications

(22 citation statements)

References 26 publications

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“…We have previously found that BD and symptomatic CL are associated with a 9- to 12-fold increase in gallbladder wall MCs when compared to controls [7]. In the current study, we confirmed that MCs are frequently present in the gallbladder wall at counts very similar to what was observed in our previous study.…”

Section: Discussionsupporting

confidence: 91%

“…The percentage of patients with elevated peak and mean cell densities, respectively, was determined. The upper limit of normal was determined as the mean + 2 SD from previous control data with upper limits defined as mean > 3.5/hpf in the LP, peak > 5.78/hpf in the LP, mean > 1.66/hpf in the MM, and peak > 4.19 in the MM [7]. MC densities were compared between BD and CL patients by the student's t test.…”

Section: Methodsmentioning

confidence: 99%

“…Previously we evaluated gallbladder wall inflammatory cells in children with symptomatic CL and BD [7]. These two conditions were associated with a 9 to 12-fold increase in mucosal MC density.…”

Section: Introductionmentioning

confidence: 99%

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Mast cell activation and clinical outcome in pediatric cholelithiasis and biliary dyskinesia

et al. 2011

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BackgroundThe current study was undertaken to determine the degree of activation of gallbladder mucosal mast cells, whether mast cell (MC) density or activation differ between patients with and without a positive clinical response to cholecystectomy, and whether either density or activation correlate with gallbladder emptying.ResultsFifteen biliary dyskinesia (BD) and 13 symptomatic cholelithiasis (CL) patients undergoing cholecystectomy were prospectively enrolled. Gallbladder wall MC density (by immunohistochemistry) and activation (by electron microscopy) were determined. Clinical response was evaluated 30 days post-cholecystectomy on a 5-point Likert-type scale. A complete or nearly complete clinical response was seen in 100% of CL and in 87% of BD patients. The overall degranulation indices were 49.4 ± 18.7% for CL patients and 44.2 ± 16.8% for BD patients. Neither MC density nor activation correlated with the gallbladder ejection fraction. A complete clinical response was associated with lower epithelial MC density.ConclusionCholecystectomy is efficacious in relieving pain in both CL and BD patients. BD and CL are associated not only with increased MC density but a moderate to high degree of MC activation. A possible relationship between MC density and outcome for BD warrants further investigation.

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Section: Discussionsupporting

confidence: 91%

Section: Methodsmentioning

confidence: 99%

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Mast cell activation and clinical outcome in pediatric cholelithiasis and biliary dyskinesia

et al. 2011

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“…Hydrophobic bile acids may also play a role in the mast cell activation and, in murine colon, induce histamine and, to a lesser degree, PG release by mast cells 17 . The GB wall is rich in histamine‐containing mast cells, which are distributed in the mucosa and muscularis/serosa layers 18 . Besides the other mediators involved in the regulation of GB motility, previous studies have focused on the role of histamine.…”

Section: Introductionmentioning

confidence: 99%

Effect of ursodeoxycholic acid on inflammatory infiltrate in gallbladder muscle of cholesterol gallstone patients

Carotti

Guarino

Cicala

et al. 2010

Neurogastroenterology Motil

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An inflammatory monocyte/macrophage, mast cell and granulocyte infiltrate is present in the GB muscle layer of GS patients. Ursodeoxycholic acid decreases macrophages, degranulated mast cells and COX-2 expression. These results suggest that monocytes/macrophages and degranulating mast cells contribute to muscle cell dysfunction in cholesterol GS patients and support the anti-inflammatory effect of UDCA.

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“…more prevalent in the gallbladders (GBs) of children with acalculous cholecystitis as compared with controls, but little else has been reported [3]. There are several factors that contribute to the lack of understanding of CAGD, including the nonspecific nature of the symptom complex, poor understanding of the natural history and pathophysiology involved, and high incidence of nonspecific abdominal pain in childhood [1,2,4].…”

mentioning

confidence: 99%

Cholecystokinin receptor positivity in children with chronic acalculous gallbladder dysfunction: a pilot study to investigate the etiology of chronic acalculous gallbladder dysfunction

Karplus

Ruiz

Thomas

et al. 2008

Journal of Pediatric Surgery

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Gallbladder wall inflammatory cells in pediatric patients with biliary dyskinesia and cholelithiasis: a pilot study

Cited by 22 publications

References 26 publications

Mast cell activation and clinical outcome in pediatric cholelithiasis and biliary dyskinesia

Mast cell activation and clinical outcome in pediatric cholelithiasis and biliary dyskinesia

Effect of ursodeoxycholic acid on inflammatory infiltrate in gallbladder muscle of cholesterol gallstone patients

Cholecystokinin receptor positivity in children with chronic acalculous gallbladder dysfunction: a pilot study to investigate the etiology of chronic acalculous gallbladder dysfunction

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