Gallenpassage von Antibiotika; Persönliche Studie der biliären Elimination der β-Lactam-Antibiotika

Jm, Brogard; Pinget, M.; Dauchel, J; Lavillaureix, J

doi:10.1007/978-3-642-72332-2_28

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“…In order to define more accurately the place of ceftizoxime among other cepha losporins, we compared its biliary concen trations in patients with a T-tube drainage with those of 8 other derivatives of the same group studied previously by a simi lar procedure [2][3][4][5]. Even if one takes into account the fact that the dosage of cefti zoxime was higher than that of the other 8 derivatives (2 g compared with 0.5 or 1 g), it appears that the biliary levels obtained after injection of this new antibiotic ( fig.…”

Section: Discussionmentioning

confidence: 99%

Biliary Excretion of Ceftizoxime in Humans

Jm¹,

Arnaud²,

Timmler³

1984

Chemotherapy

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Biliary concentrations of a new cephalosporin, ceftizoxime, were measured in bile collected in 8 cholecystectomized patients provided with T-tube drainage and in 14 patients where bile was obtained by puncture of the gall bladder and choledochus during cholecystectomy. In patients with external biliary drainage, a mean biliary peak of 150.3 ± SEM 49.8 μg/ml has been observed 2 h after intravenous injection of 2 g of ceftizoxime; the antibiotic activity amounted still to 17.3 ± 6.0 μg/ml after 6 h. Assays performed during operation showed the following simultaneous concentrations 1 h after 2g of ceftizoxime given intravenously: serum: 85.3 ± 8.1 μg/ml; main duct bile: 279.8 ± 40.0 μg/ml; gallbladder bile: 119.9 ± 19.4 μg/ml. These findings were compared with the biliary excretion of 8 other cephalosporins studied previously under the same conditions. The results of the present study suggest that administration of ceftizoxime may be effective in the treatment of biliary tract infections.

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Section: Discussionmentioning

confidence: 99%