Galli Gigerii Endothelium Corneum derived fluorescent carbon dots and their application as sensing platform for nitroimidazoles and cell imaging

An overview on animal/human biomass-derived carbon dots for optical sensing and bioimaging applications

“…6. 216 The N-CDs in this report showed a small average particle size (∼2.46 nm) and good QY (19.45%) due to the effective graphitization of the core and increased N content in the core graphene, which resulted in more PL contribution from the core state rather than the molecular state. X-ray photoelectron spectroscopy (XPS) analysis also validated the low amino N-content compared to the graphene N-content in the synthesized N-CDs.…”

“…Animal/human biomass-derived doped CDs have been successfully applied to detect various drug molecules such as curcumin, 131 lidocaine hydrochloride (C 14 H 22 N 2 O·HCl, LH), 223 ceftriaxone (CFX), 180,214 tetracyclines (TCs), 195,233 6-thioguanine (6-TG), 213 nitroimidazoles, 216 thiamphenicol (TAP), 185 and clozapine (CLZ) 243 via the turn on–off-based quenching process (Table 2). Noticeably, the LOD of CFX drug with chicken drumstick-derived N-CDs (0.44 nM) 214 was much improved compared to the previously reported crab shell-derived N-CDs (9.0 nM).…”

Recent Advances in Synthesis, Modification, Characterization, and Applications of Carbon Dots

“…The M-CDs-conjugated HTC-116 cells emitted blue, green, and red light when excited through 405, 488, and 555 nm filters, respectively. An efficient and environmentally friendly process for the preparation of nitrogen-doped carbon dots (N-CDs) was reported, using chicken waste Galli Gigerii Endothelium Corneum (GGEC) as a precursor [ 166 ]. Surprisingly, N-CDs can be used as a sensor for the selective and sensitive detection of nitroimidazoles, such as metronidazole, tinidazole, ornidazole, and secnidazole, using internal filtration effect (IFE) and static quenching mechanisms.…”

Rapid microwave-assisted synthesis of nitrogen-doped carbon quantum dots as fluorescent nanosensors for the spectrofluorimetric determination of palbociclib: application for cellular imaging and selective probing in living cancer cells

“…The construction of a novel multifunctional uorescence platform as carbon quantum dots (CQDs) is gaining great attention in the determination of different pharmaceutical compounds, metals, and biological compounds, as well as cellular imaging. [10][11][12][13][14][15][16][17][18][19][20][21] They are similar in size and photo-electrochemical properties; however, they vary in the internal structure and surface chemical groups. They are mono-disperse spherical nanoparticles with a carbon-based skeleton and a large number of oxygen-containing groups on the surface.…”