Gallic Acid Attenuated LPS-Induced Neuroinflammation: Protein Aggregation and Necroptosis

Liu, Yuling; Hsu, Chia Chi; Huang, Hui-Ju; Chang, Chi-Jen; Sun, Shuhui; Lin, Anya Maan-Yuh

doi:10.1007/s12035-019-01759-7

Cited by 83 publications

(61 citation statements)

References 29 publications

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“…It is also hepatoprotective and antihyperglycaemic 7 . like many natural antioxidants, it is a potent scavenger of trichloromethyl radicals that prevents lipid peroxidation through the generation of tocopheryl radicals scavengers; it also averts H 2 O 2 induced lipid peroxidation as well as the production of OH-deoxyguanosine 8 . Despite having all the aforementioned therapeutic properties, gallic acid use is restricted by its poor absorption, rapid elimination, and low bioavailability 9 , 10 .…”

Section: Introductionmentioning

confidence: 99%

Preparation, characterization and therapeutic properties of gum arabic-stabilized gallic acid nanoparticles

Hassani

Azarian

Ibrahim

et al. 2020

Sci Rep

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Gallic acid (GA) is a natural phenolic compound with therapeutic effects that are often challenged by its rapid metabolism and clearance. Therefore, GA was encapsulated using gum arabic into nanoparticles to increase its bioavailability. The formulated nanoparticles (GANPs) were characterized for physicochemical properties and size and were then evaluated for antioxidant and antihypertensive effects using various established in vitro assays, including 1,1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide scavenging (NO), β-carotene bleaching and angiotensin-converting enzyme (ACE) inhibitory assays. The GANPs were further evaluated for the in vitro cytotoxicity, cell uptake and cell migration in four types of human cancer cell lines including (MCF-7, MDA-MB231) breast adenocarcinoma, HepG2 hepatocellular cancer, HT-29 colorectal adenocarcinoma, and MCF-10A breast epithelial cell lines. The GANPs demonstrated potent antioxidant effects and have shown promising anti-cancer properties in a dose-dependent manner with a predilection toward HepG2 and MCF7 cancer cells. The uptake of GANPs was successful in the majority of cancer cells with a propensity to accumulate in the nuclear region of the cells. The HepG2 and MCF7 cancer cells also had a significantly higher percentage of apoptosis and were more sensitive to gallic acid nanoparticle treatment in the cell migration assay. This study is the first to confirm the synergistic effects of gum arabic in the encapsulation of gallic acid by increasing the selectivity towards cancer cells and enhancing the antioxidant properties. The formulated nanoparticles also had remarkably low toxicity in normal cells. Based on these findings, GANPs may have promising therapeutic applications towards the development of more effective treatments with a probable targeting precision in cancer cells.

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Section: Introductionmentioning

confidence: 99%

Preparation, characterization and therapeutic properties of gum arabic-stabilized gallic acid nanoparticles

Hassani

Azarian

Ibrahim

et al. 2020

Sci Rep

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“…The stilbene group is best exemplified by resveratrol, a well-known phenolic compound found in red wine, grape, and virgin olive oil, which has shown remarkable neuroprotective and anti-aging properties in a plethora of experimental models [ 50 , 58 , 59 , 65 , 69 , 97 , 98 , 99 , 100 , 101 , 102 ]. Finally, phenolic acids, which can be subdivided into hydroxybenzoic acids (such as syringic and gallic acids) [ 103 , 104 , 105 ] and hydroxycinnamic acids (such as ferulic, caffeic, and chlorogenic acids, including the derivatives rosmarinic acid, salvianolic acid, and curcumin), have shown encouraging results in various experimental models of neurodegeneration, neurotoxicity and neurological insults [ 3 , 54 , 57 , 62 , 66 , 70 , 106 , 107 ].…”

Section: An Overview Of Neuroprotective Phytochemical Classesmentioning

confidence: 99%

“…In the last decades, the search for an effective and potentially safe strategy to combat oxidative stress-mediated neuronal damage has increasingly prompted the investigation of naturally occurring compounds as antioxidant agents. The attenuation of oxidative stress by bioactive compounds belonging to different classes of phytochemicals including (i) flavonoids (quercetin, kaempferol and myricetin, scutellarin, baicalin, apigenin, catechins, epigallocatechin, and genistein) [ 52 , 61 , 81 , 82 , 83 , 88 , 94 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 ]; (ii) phenolic acids (syringic, gallic, caffeic, chlorogenic and salvianolic acids, and curcumin) [ 70 , 103 , 104 , 105 , 138 , 139 , 140 , 141 , 142 , 143 ]; (iii) flavonolignans (silymarin) [ 96 ]; (iv) stilbenes (resveratrol) [ 59 , 65 , 97 , 98 , 144 ]; (v) terpenes (bacosides/bacopasides, withanolides, and the carotenoids lutein and zeaxanthin) [ 7 , 110 , 113 , 115 , 145 , 146 , 147 ]; (vi) alkaloids (berberine and caffeine) [ 148 , 149 ]; (vii) glucosinolates (sulforaphane) and polyamines (spermine/spermidine) [ 123 , 124 ,…”

Section: Phytochemicals and Oxidative Stressmentioning

confidence: 99%

Merging the Multi-Target Effects of Phytochemicals in Neurodegeneration: From Oxidative Stress to Protein Aggregation and Inflammation

et al. 2020

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Wide experimental evidence has been provided in the last decade concerning the neuroprotective effects of phytochemicals in a variety of neurodegenerative disorders. Generally, the neuroprotective effects of bioactive compounds belonging to different phytochemical classes are attributed to antioxidant, anti-aggregation, and anti-inflammatory activity along with the restoration of mitochondrial homeostasis and targeting alterations of cell-clearing systems. Far from being independent, these multi-target effects represent interconnected events that are commonly implicated in the pathogenesis of most neurodegenerative diseases, independently of etiology, nosography, and the specific misfolded proteins being involved. Nonetheless, the increasing amount of data applying to a variety of neurodegenerative disorders joined with the multiple effects exerted by the wide variety of plant-derived neuroprotective agents may rather confound the reader. The present review is an attempt to provide a general guideline about the most relevant mechanisms through which naturally occurring agents may counteract neurodegeneration. With such an aim, we focus on some popular phytochemical classes and bioactive compounds as representative examples to design a sort of main highway aimed at deciphering the most relevant protective mechanisms which make phytochemicals potentially useful in counteracting neurodegeneration. In this frame, we emphasize the potential role of the cell-clearing machinery as a kernel in the antioxidant, anti-aggregation, anti-inflammatory, and mitochondrial protecting effects of phytochemicals.

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“…The biological effect of GA has been previously studied. Liu et al (2020a) investigate the neuroprotective effect of daily orally administered GA. Adult male Sprague Dawley rats (250-350 g) were randomly divided into three groups (n = 7/group) treated either with saline solution (control group) or orally administrated GA at 50 mg/kg or 100 mg/kg via an intragastric needle 1 h prior to an intranigral infusion of lipopolysaccharides (LPS), 4µg/µL, to induce neuroinflammation.…”

Section: Phenolic Acidsmentioning

confidence: 99%

Pomegranate as a natural source of phenolic antioxidants: a review

Arruda¹,

Lima²,

Casarotti³

et al. 2020

Journal of Food Bioactives

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Pomegranate, a recognized source of phenolic compounds, has been associated with health-promoting benefits, mostly due to its antioxidant activity. Ellagic and gallic acids, anthocyanins, and ellagitannins are the main phenolics in pomegranate, showing antioxidant activity. For this reason, pomegranate has been used in foods, such as meat products, as an attempt to retard lipid oxidation and increase shelf-life. In recent years, in vitro, in vivo, and human studies reported the antioxidant activity of pomegranate, especially its peels, with reduced incidence of chronic diseases (e.g., cardiovascular ailments, cancer, neurodegenerative disease, type 2 diabetes, chronic kidney disease). This review aims to present the main antioxidant compounds on pomegranate and their biological effects, the antioxidant activity of pomegranate-based foods, the application of pomegranate as a natural antioxidant food additive, the role of pomegranate in the prevention and management of chronic diseases, as well as the trends and prospects regarding the application of pomegranate in innovative food and health.

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Gallic Acid Attenuated LPS-Induced Neuroinflammation: Protein Aggregation and Necroptosis

Cited by 83 publications

References 29 publications

Preparation, characterization and therapeutic properties of gum arabic-stabilized gallic acid nanoparticles

Preparation, characterization and therapeutic properties of gum arabic-stabilized gallic acid nanoparticles

Merging the Multi-Target Effects of Phytochemicals in Neurodegeneration: From Oxidative Stress to Protein Aggregation and Inflammation

Pomegranate as a natural source of phenolic antioxidants: a review

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