Gallic acid attenuates thymic involution in the d-galactose induced accelerated aging mice

Guo, Li; Cao, Jiahui; Wei, Tingting; Li, Jie-Han; Feng, Yuan‐kang; Wang, Liping; Sun, Yunguang; Chai, Yurong

doi:10.1016/j.imbio.2019.11.005

Cited by 20 publications

(10 citation statements)

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“…that gallic acid treatment increased the expression of FoxN1 and FoxN1 might be related to thymic senescence (Guo et al, 2020). In the current study, it was found that FoxN1's expression was elevated after RSV supplementation through IHC and qRT-PCR analysis.…”

Section: Discussionsupporting

confidence: 49%

“…The detailed mechanism of thymic involution is still unclear. Some interventions are currently being studied to prevent the involution of the thymus and restore the immune function with aging (Guo et al, 2020). Resveratrol (RSV) was one of the polyphenolic compounds found in plants including red wine, grapes, berries, nuts, and other foods at present (Prasad, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Dosage effects of resveratrol on thymus involution in D‐galactose‐treated mice

et al. 2021

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The thymus regulates a specific microenvironment for the growth and maturation of naive T cells. Involution of immune function was an important factor during body aging. Preventing the senescence of immune organs has become a major medical issue. Resveratrol (RSV) has been proved to delay the aging of many organs including the thymus. However, the underlying mechanism remains indefinite and the dosages of RSV on thymus involution need to be further clarified. In the current study, the senescence-accelerated mice were produced using d-galactose for two months. RSV at different dosages (25, 50, 100 mg kg −1 day −1 ) was then administered. The alteration of the thymic morphological structure was observed. It showed that three dosages of RSV significantly decreased cellular senescence of the thymus and no dosage difference was detected. For cellular proliferation and apoptosis of the thymus, 50 and 25 mg/kg per day of RSV displayed the best effects on cellular proliferation and apoptosis in the thymus, respectively. Furthermore, 50 mg/kg per day of RSV increased the expression of FoxN1 both at transcription and translation levels. These findings indicated that RSV could delay thymus atrophy in a dosage-dependent pattern and FoxN1 might involve in the beneficial mechanism of RSV, which was of great significance for the enhancement of thymic health and organic immunity. Practical applicationsResveratrol has been proved to delay aging of many organs including of thymus. In the present study, we explored the dosage of resveratrol on thymus involution and the expression of transcription factors forkhead box protein N1 (FoxN1) in the senescenceaccelerated mice induced by D-galactose. The results indicated that resveratrol could delay thymus atrophy in a dosage-dependent pattern within a certain dose range, and higher RSV concentration may have drug toxicity, which suggests that the dosage of RSV requires attention, And FoxN1 might involve in the beneficial mechanism of resveratrol supplement, which was of great significance to explore the mechanism for the enhancement of thymus immunity. K E Y W O R D S d-galactose, FoxN1, resveratrol, thymus involution How to cite this article: Wei T-T, Feng Y-K, Cao J-H, et al. Dosage effects of resveratrol on thymus involution in D-galactose-treated mice.

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Section: Discussionsupporting

confidence: 49%

Section: Introductionmentioning

confidence: 99%

Dosage effects of resveratrol on thymus involution in D‐galactose‐treated mice

et al. 2021

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“…23 It has often been used to establish an aging animal model. 24 D-gal is the main component of lactose and plays the role of a metabolite in glucose metabolism. 25 D-gal can induce the production of advanced glycosylation products and reactive oxygen species, and the accumulation of such products can cause metabolism disorders and finally aging.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol ameliorates thymus senescence changes in D‐galactose induced mice

Wei

Guo

et al. 2020

Microbiology and Immunology

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The thymic microenvironment plays an important role in the development of T cells. A decrease of thymic epithelial cells is the main cause of age‐related thymic atrophy or degeneration. Resveratrol (RSV), a phytoalexin produced from plants, has been shown to inhibit the adverse effects of dietary obesity on the structure and function of the thymus. D‐Galactose (D‐gal) can induce accelerated aging in mice. In the present study, young mice (2 months old) were injected with D‐gal (120 mg/kg/day) for 8 consecutive weeks to construct an accelerated aging model. Compared with normal control mice, the thymus epithelium of the D‐gal treated mice had structural changes, the number of senescent cells increased, the number of CD4+ T cells decreased, and CD8+ T cells increased. After RSV administration by gavage for 6 weeks, it was found that RSV improved the surface phenotypes of D‐gal treated mice, and recovered thymus function by maintaining the ratio of CD4+ to CD8+ cells. It also indicated that RSV enhanced the cell proliferation and inhibited cell senescence. Increased autoimmune regulator (Aire) expression was present in the RSV treated mice. The lymphotoxin‐beta receptor (LTβR) expression also increased. These findings suggested that RSV intake could restore the alterations caused by D‐gal treatment in the thymus via stimulation of Aire expression.

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“…Several important pharmacological effects of GA have been reported, including antioxidant, antiinflammatory, and antineoplastic properties. Previous studies showed that GA could enhance the activity of antioxidant enzymes (catalase and glutathione peroxidase) and rejuvenate immune function in D-gal-induced aging-accelerated mice (Guo et al, 2020). GA can also protect healthy subjects and type 2 diabetes patients from DNA oxidation damage (Ferk et al, 2018).…”

Section: Cellmentioning

confidence: 99%