Gallic acid-coated silver nanoparticles as perspective drug nanocarriers: bioanalytical study

Nemčeková, Katarína; Svitková, Veronika; Sochr, Jozef; Gemeiner, Pavol; Labuda, Ján

doi:10.1007/s00216-022-03955-2

Cited by 26 publications

(16 citation statements)

References 56 publications

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“…As a result, gallic acid tends to form chelating rings with various metal ions derived from metal precursors. During the NPs synthesis process, gallic acid itself is oxidized to benzoquinones [ 26 , 27 , 28 ]. Importantly, gallic acid also acts as a stabilizer of these reactions; it prevents the assembly of NPs into larger agglomerates.…”

Section: Resultsmentioning

confidence: 99%

Improving the Effect of Cancer Cells Irradiation with X-rays and High-Energy Protons Using Bimetallic Palladium-Platinum Nanoparticles with Various Nanostructures

Klębowski

Stec

Depciuch

et al. 2022

Cancers

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Nano-sized radiosensitizers can be used to increase the effectiveness of radiation-based anticancer therapies. In this study, bimetallic, ⁓30 nm palladium-platinum nanoparticles (PdPt NPs) with different nanostructures (random nano-alloy NPs and ordered core-shell NPs) were prepared. Scanning transmission electron microscopy (STEM), selected area electron diffraction (SAED), energy-dispersive X-ray spectroscopy (EDS), zeta potential measurements, and nanoparticle tracking analysis (NTA) were used to provide the physicochemical characteristics of PdPt NPs. Then, PdPt NPs were added to the cultures of colon cancer cells and normal colon epithelium cells in individually established non-toxic concentrations and irradiated with the non-harmful dose of X-rays/protons. Cell viability before and after PdPt NPs-(non) assisted X-ray/proton irradiation was evaluated by MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) assay. Flow cytometry was used to assess cell apoptosis. The results showed that PdPt NPs significantly enhanced the effect of irradiation on cancer cells. It was noticed that nano-alloy PdPt NPs possess better radiosensitizing properties compared to PtPd core-shell NPs, and the combined effect against cancer cells was c.a. 10% stronger for X-ray than for proton irradiation. Thus, the radio-enhancing features of differently structured PdPt NPs indicate their potential application for the improvement of the effectiveness of radiation-based anticancer therapies.

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Section: Resultsmentioning

confidence: 99%

Improving the Effect of Cancer Cells Irradiation with X-rays and High-Energy Protons Using Bimetallic Palladium-Platinum Nanoparticles with Various Nanostructures

Klębowski

Stec

Depciuch

et al. 2022

Cancers

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“…DNA-drug interactions are of permanent interest, particularly for species that in- The protective effect of AgNPs can be explained by their already reported direct interaction with the structure of dsDNA [68] and probably also by an interaction of TCS with AgNPs similarly to TiO 2 nanoparticles [71]. It seems that Ag1NPs with smaller dimensions (15 nm) adsorb on the dsDNA structure in a greater amount than Ag2NPs (37 nm), and somewhat better prevent the interaction of triclosan with dsDNA.…”

Section: Discussionmentioning

confidence: 99%

“…The corresponding SWV current responses of the deoxynucleotides decreased with the concentration of nanoparticles applied. This decrease can be explained by a barrier effect for electron transfer evidently caused by an association of AgNPs with the dsDNA backbone as recently described [68]. Based on these results, the concentration of 1 × 10 −4 mol•L −1 Ag1 and Ag2 nanoparticles was chosen for ongoing measurements which corresponds to a 1:10 (v/v) dilution of nanoparticles stock solution with PB.…”

Section: Effect Of Agnps On Dna/gce Biosensormentioning

confidence: 90%

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Effect of Triclosan and Silver Nanoparticles on DNA Damage Investigated with DNA-Based Biosensor

Blaškovičová

Labuda

2022

Sensors

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Triclosan (TCS) is a broad-spectrum antimicrobial agent widely used in personal care, healthcare, and clinical practice. One of the most important aspects of toxicological profiling of compounds is their interaction with DNA. In human cells, TCS causes a significant reduction in DNA methylation. The involvement of TCS in chromosomal aberrations, DNA damage, and strand breaks, as well as DNA damage from TCS degradation products, was reported. AgNPs share similarities with TCS in terms of antimicrobial properties, enter the body after exposure, and are used even together with TCS in oral care products. Therefore, their mutual effect on the DNA is of interest. In this study, the electrochemical behavior of TCS on a glassy carbon electrode (GCE) and the biosensor with salmon sperm dsDNA (DNA/GCE), DNA damage by TCS present in phosphate buffer solution pH 7.4 and an additional effect of the immobilized AgNP layer on such DNA damage have been investigated. Two different sizes of AgNPs (about 15 and 37 nm) were tested. Using square-wave voltammetric signals of nucleobases, the portion of survived DNA was 64% in the presence of 15 nm AgNPs compared to 55% in its absence. The protective effect of AgNPs on DNA against TCS-induced DNA damage was found.

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“…Glucose detection was demonstrated using AuNP in serum, showing detection limits in the nanomole region [ 76 ]. Metals such as silver have also played a role in the therapeutic drug research space as in the case where gallic acid-coated silver nanoparticles were used as drug carriers for doxorubicin [ 77 ]. Silver NPs are also capable of detecting uric acid, lidocaine hydrochloride, thiamine, lomefloxacin, and propafenone in urine samples with detection limits in the micromolar per liter range [ 78 , 79 , 80 , 81 , 82 ].…”

Section: Nanomaterials Scaffolds and Therapeutic Drug Applicationsmentioning

confidence: 99%

Chemical Sensor Nanotechnology in Pharmaceutical Drug Research

2022

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The increase in demand for pharmaceutical treatments due to pandemic-related illnesses has created a need for improved quality control in drug manufacturing. Understanding the physical, biological, and chemical properties of APIs is an important area of health-related research. As such, research into enhanced chemical sensing and analysis of pharmaceutical ingredients (APIs) for drug development, delivery and monitoring has become immensely popular in the nanotechnology space. Nanomaterial-based chemical sensors have been used to detect and analyze APIs related to the treatment of various illnesses pre and post administration. Furthermore, electrical and optical techniques are often coupled with nano-chemical sensors to produce data for various applications which relate to the efficiencies of the APIs. In this review, we focus on the latest nanotechnology applied to probing the chemical and biochemical properties of pharmaceutical drugs, placing specific interest on several types of nanomaterial-based chemical sensors, their characteristics, detection methods, and applications. This study offers insight into the progress in drug development and monitoring research for designing improved quality control methods for pharmaceutical and health-related research.

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Gallic acid-coated silver nanoparticles as perspective drug nanocarriers: bioanalytical study

Cited by 26 publications

References 56 publications

Improving the Effect of Cancer Cells Irradiation with X-rays and High-Energy Protons Using Bimetallic Palladium-Platinum Nanoparticles with Various Nanostructures

Improving the Effect of Cancer Cells Irradiation with X-rays and High-Energy Protons Using Bimetallic Palladium-Platinum Nanoparticles with Various Nanostructures

Effect of Triclosan and Silver Nanoparticles on DNA Damage Investigated with DNA-Based Biosensor

Chemical Sensor Nanotechnology in Pharmaceutical Drug Research

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