Gallic acid exerts anti-inflammatory, anti-oxidative stress, and nephroprotective effects against paraquat-induced renal injury in male rats

Nouri, Ali; Heibati, Fatemeh; Heidarian, Esfandiar

doi:10.1007/s00210-020-01931-0

Cited by 72 publications

(44 citation statements)

References 49 publications

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“…2). Previous works have reported antioxidants to have anti-in ammatory activity by reducing in ammatory factors (Nouri et al, 2017, Nouri et al, 2021. It seems the roles of ellagic acid and taurine to be relative to their antioxidant properties.…”

Section: Discussionmentioning

confidence: 96%

WITHDRAWN: Evaluation of the Protective Effects of Ellagic Acid and Taurine on Lipid Profile and Gene Expressions of NF-κB, IL-1β, and TNF-α against Fluoxetine Induced Hepatotoxicity in Male Wistar Rats

Beigi

Satvati

Safi

et al. 2021

Preprint

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Purpose Fluoxetine by increasing free radicals can cause hepatotoxicity. Ellagic acid and taurine have antioxidant properties. In this study, the protective effects of ellagic acid and taurine against fluoxetine-induced liver damage were examined Methods The animals were divided into five groups as follows: group 1: controls receiving corn oil; group 2: receiving fluoxetine 15 mg/kg body weight (bw); group 3: receiving fluoxetine 15mg/kg bw and ellagic acid 50 mg/kg bw; group 4: receiving fluoxetine 15 mg/kg bw and taurine 100 mg/kg bw; and group 5: receiving 15mg/kg bw, ellagic acid 50 mg/kg bw, and taurine 100 mg/kg bw. Results Fluoxetine significantly raised serum uric acid, malondialdehyde (MDA), protein carbonyl (PC), lipids profile, serum glutamate pyruvate transaminase (GPT), serum glutamate oxaloacetate transaminase (GOT), alkaline phosphatase (ALP), total bilirubin, and serum interleukin-1 beta; and gene expressions of interleukin-1beta (IL-1B), nuclear factor kappa B (NF-κB), and tumor necrosis factor-alpha (TNF-α). Moreover, it significantly decreased (p < 0.05) high-density lipoprotein cholesterol (HDL-C), ferric reducing/antioxidant power (FRAP), catalase (CAT), vitamin C, and superoxide dismutase (SOD) in the liver compared to group 1. Treatment with ellagic acid and taurine significantly elevated antioxidant capacity and decreased hepatotoxic biochemical parameters and cells’ inflammation compared to group 2. Also, the results confirm that treatment with ellagic acid and taurine improved tissue change and liver function. Conclusion Our study has concluded the beneficial effect of ellagic acid and taurine against fluoxetine-induced hepatotoxicity. This effect is derived from free radical scavenging properties and the anti-inflammatory effect related to IL-1B, NF-κB, TNF-α.

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Section: Discussionmentioning

confidence: 96%

WITHDRAWN: Evaluation of the Protective Effects of Ellagic Acid and Taurine on Lipid Profile and Gene Expressions of NF-κB, IL-1β, and TNF-α against Fluoxetine Induced Hepatotoxicity in Male Wistar Rats

Beigi

Satvati

Safi

et al. 2021

Preprint

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“…Intense body weight loss is expected during cancer cachexia, as verified in the AW animals in this study, and similar to others’ results for this same tumour model [ 27 , 28 , 29 ]. The tumour also affected the body growth and development in WW animals, but to a lesser extent, probably because this group was still in the growing phase.…”

Section: Discussionsupporting

confidence: 93%

A Time-Course Comparison of Skeletal Muscle Metabolomic Alterations in Walker-256 Tumour-Bearing Rats at Different Stages of Life

et al. 2021

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Cancer cachexia is a severe wasting condition that needs further study to find ways to minimise the effects of damage and poor prognosis. Skeletal muscle is the most impacted tissue in cancer cachexia; thus, elucidation of its metabolic alterations could provide a direct clue for biomarker research and be applied to detect this syndrome earlier. In addition, concerning the significant changes in the host metabolism across life, this study aimed to compare the metabolic muscle changes in cachectic tumour-bearing hosts at different ages. We performed 1H-NMR metabolomics in the gastrocnemius muscle in weanling and young adult Walker-256 tumour-bearing rats at different stages of tumour evolution (initial, intermediate, and advanced). Among the 49 metabolites identified, 24 were significantly affected throughout tumour evolution and 21 were significantly affected regarding animal age. The altered metabolites were mainly related to increased amino acid levels and changed energetic metabolism in the skeletal muscle, suggesting an expressive catabolic process and diverted energy production, especially in advanced tumour stages in both groups. Moreover, these changes were more severe in weanling hosts throughout tumour evolution, suggesting the distinct impact of cancer cachexia regarding the host’s age, highlighting the need to adopting the right animal age when studying cancer cachexia.

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“…This valuable compound does not only maintain the integrity of cell membrane but also increases the regenerative capacity of the kidney and liver [25]. Furthermore, Gallic acid and its derivations have anticancer properties due to antioxidant and anti-inflammatory features [26].…”

Section: Introductionmentioning

confidence: 99%

Ameliorative Effects of Gallic Acid on Cisplatin-Induced Nephrotoxicity in Rat Variations of Biochemistry, Histopathology, and Gene Expression

Eslamifar

Moridnia

Sabbagh

et al. 2021

BioMed Research International

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Background. Cisplatin is a powerful chemotherapeutic drug mainly used in the treatment of solid tumors. Aggregation of the drug in renal proximal tubule cells causes nephrotoxicity and renal failure. Investigations showed nephrotoxicity as Cisplatin’s dose-limiting side effect. One of the Cisplatin toxicity mechanisms is generation of reactive oxygen species, which leads to oxidative stress and renal damage. The purpose of this study was evaluation of the modulating effects of Gallic acid on Cisplatin-induced variations including Caspase-3 and Clusterin expression and histopathological and biochemical parameters in adult male Wistar rats. Method. Rats were kept under standard condition of temperature, light, and humidity. The animals were divided into 4 groups: GpI: control group (received distilled water for 10 days); GpII: Gallic acid (alone) (50 mg/kg bw, once a day for 10 days); GpIII: Cisplatin (alone), single dose (6 mg/kg bw, I.P. on 5th day of study); GpIV: Gallic acid (50 mg/kg bw, once a day for 10 days) and also injected with single dose of Cisplatin (6 mg/kg bw, I.P., on 5th day of study). After 10 days, all rats were anaesthetized and plasma collected to estimate urea, creatinine, and uric acid. The right kidneys were removed for the study of gene expression and biochemical parameters. The left kidneys were used for histopathological studies. Results. The Cisplatin-induced nephrotoxicity was evident from the elevated levels of creatinine, urea, uric acid, and renal tissue MDA and also decreased levels of SOD, CAT, GPX, and GSH in renal tissue. Administration of Gallic acid significantly modulated nephrotoxicity markers, gene expression variations, and histopathological damage. Conclusion. Outcomes of the present investigation suggest that Gallic acid provides protection against CP-induced nephrotoxicity, but for application in people, further studies are needed.

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Gallic acid exerts anti-inflammatory, anti-oxidative stress, and nephroprotective effects against paraquat-induced renal injury in male rats

Cited by 72 publications

References 49 publications

WITHDRAWN: Evaluation of the Protective Effects of Ellagic Acid and Taurine on Lipid Profile and Gene Expressions of NF-κB, IL-1β, and TNF-α against Fluoxetine Induced Hepatotoxicity in Male Wistar Rats

WITHDRAWN: Evaluation of the Protective Effects of Ellagic Acid and Taurine on Lipid Profile and Gene Expressions of NF-κB, IL-1β, and TNF-α against Fluoxetine Induced Hepatotoxicity in Male Wistar Rats

A Time-Course Comparison of Skeletal Muscle Metabolomic Alterations in Walker-256 Tumour-Bearing Rats at Different Stages of Life

Ameliorative Effects of Gallic Acid on Cisplatin-Induced Nephrotoxicity in Rat Variations of Biochemistry, Histopathology, and Gene Expression

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