Gallic Acid Glycerol Ester Promotes Weight-Loss in Rats

Totani, Nagao; Tateishi, Sayuri; Takimoto, Tatsuya; Maeda, Yukari; Sasaki, Hideaki

doi:10.5650/jos.60.457

Cited by 12 publications

(8 citation statements)

References 22 publications

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“…We assumed that the SOL 50% EtOH extract likely activated AMPK because it decreased the expression of ACC and increased expression of adiponectin and CPT-1. Although it is well known that ellagic and gallic acids have antiobesity effects as in several studies, 48,49 further studies on which components in the SOL 50% EtOH extract exert the antiobesity effects are needed.…”

Section: Discussionmentioning

confidence: 98%

Sanguisorba officinalisL. Extracts Exert Antiobesity Effects in 3T3-L1 Adipocytes and C57BL/6J Mice Fed High-Fat Diets

Jung

Lee

Kang

2016

Journal of Medicinal Food

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The purpose of this study was to investigate the antiobesity effect of Sanguisorba officinalis L. (SOL) in 3T3-L1 adipocytes and obese C57BL/6J mice. SOL was extracted with water and 30%, 50%, 70%, and 100% ethanol (EtOH). 3T3-L1 adipocytes were treated with SOL extracts (100 μg/mL) during the differentiation period. Triglyceride (TG) accumulation was determined by Oil Red O staining, and the expression of adipocyte-specific proteins was measured by Western blot analysis. C57BL/6J mice were fed a high-fat diet to induce obesity and were orally administered SOL 50% ethanol extract (50, 100, and 200 mg/kg) for 8 weeks. Among the SOL extracts, the 50% EtOH extract considerably inhibited TG accumulation through the downregulation of PPARγ, C/EBPα, and SREBP-1c in 3T3-L1 adipocytes. In addition, the 50% ethanol extract reduced body weight and adipose tissue weight and improved serum lipid profiles through downregulation of PPARγ, C/EBPα, FABP4, and ACC and upregulation of adiponectin and CPT-1 in obese C57BL/6J mice fed a high-fat diet. These results suggested that the SOL 50% EtOH extract may have an antiobesity effect through the regulation of transcription factors related to adipogenesis, lipogenesis, and lipolysis.

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Section: Discussionmentioning

confidence: 98%

Sanguisorba officinalisL. Extracts Exert Antiobesity Effects in 3T3-L1 Adipocytes and C57BL/6J Mice Fed High-Fat Diets

Jung

Lee

Kang

2016

Journal of Medicinal Food

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“…[11] GA administration induces weight loss, improves glucose tolerance, lowers triglyceride concentrations, and increases insulin sensitivity after GA in preclinical models of T2D. [12][13][14][15][16] GA administration to humans also has anti-obesity effects. [17] The oral administration of EGCG also decreases blood glucose, improves lipid parameters, and reduces inflammatory cytokines in preclinical models of MetS.…”

Section: Doi: 101002/mnfr201700770mentioning

confidence: 99%

“…GA and EGCG are both reported to have beneficial effects on MetS . GA administration induces weight loss, improves glucose tolerance, lowers triglyceride concentrations, and increases insulin sensitivity after GA in preclinical models of T2D . GA administration to humans also has anti‐obesity effects .…”

Section: Introductionmentioning

confidence: 99%

GPCR6A Is a Molecular Target for the Natural Products Gallate and EGCG in Green Tea

Kapoor

et al. 2018

Molecular Nutrition Food Res

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“…Thus, the hydroxyl group of FerA appeared to be associated with the ability to promote weight loss. We previously showed 11 in a similar animal experiment that DOGGA, an ester of gallic acid and dioleoyl glycerol, promoted weight loss more effectively than gallic acid. In addition, Wilson et al 8 reported that γ-oryzanol, a mixture of ferulic acid esters, lowers cholesterol more effectively than ferulic acid, a fi nding that is supported by the present results.…”

Section: Discussionmentioning

confidence: 99%