Gallic acid improves endothelium‐dependent vasodilatory response to histamine in the mesenteric vascular bed of diabetic rats

Badavi, Mohammad; Bazaz, Amir; Dianat, Mahin; Sarkaki, Alireza

doi:10.1111/1753-0407.12513

Cited by 4 publications

(5 citation statements)

References 36 publications

(102 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The administration of GA improved the alloxan-induced hypotension toward controls. This protective effect of GA may be due to the improvement of oxidant/anti-oxidant ratio and glucose homeostasis that observed in this study and/ or ventricular contractility, peripheral resistance and arterial compliance induced by diabetes (13). It has been reported that GA improved ventricular contractility and peripheral resistance in patients with cardiovascular disorders (31).…”

Section: Discussionsupporting

confidence: 65%

“…GA is a natural component that belongs to the larger family of polyphenols and is specifically found in gallnuts, grapes, tea leaves, oak bark, blackberry and pomegranates (12). A previous investigation has shown that GA could restore vasodilator response of mesenteric arterial bed to histamine using the endothelium H1 receptor in diabetic rats (13). On the other hand, antioxidant agents acting on ROS and ionic pumps dysfunction in the heart in high glucose conditions provide protection against the QT interval prolongation (14).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Gallic Acid Improves Oxidative Stress and Inflammation Through Regulating Micrornas Expressions in the Blood of Diabetic Rats

Badavi

Dianat

et al. 2019

Acta Endo (Buc)

View full text Add to dashboard Cite

Context. Endothelial dysfunction and diabetic cardiomyopathy are critical complications of diabetes. Gallic acid (GA) plays a significant role in cardiovascular disorders resulted from diabetes. In addition, increased plasma miR-24, miR-126 associated with endothelial dysfunction. Aim. The current study was designed to assess the effects of GA on plasma miR-24, miR-126 levels in the diabetic rats. Animals and Methods. Adult male Sprague-Dawley rats were divided into three groups (n=8): control (C), diabetic (D) and diabetic group treated with GA (D+G, 25 mg/kg, by gavage) for eight weeks. The blood glucose level, body weight, lipid profile, blood pressure, plasma miR-24 and miR-126 levels, antioxidant and inflammatory biomarkers were measured. Results. The plasma levels of miR-24, miR-126, body weight, high-density lipoprotein cholesterol (HDL-c), total anti-oxidant capacity (TAC) and the systolic blood pressure significantly reduced and blood glucose, total cholesterol (TC), triglycerides (TG), very low-density lipoprotein cholesterol (VLDL-c), malondialdehyde (MDA), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) and low-density lipoprotein cholesterol (LDL-c) significantly elevated among the diabetic rats compared with the control group. However, GA restored body weight, blood pressure, TC, TG, VLDL-c, TNF-α, miR-126, blood glucose, HDL-c, MDA, TAC, miR-24 and IL-6 among the GA treated rats compared with the diabetic group. Conclusion. GA improves inflammation, oxidative stress and hypotension result from diabetes. These protective effects are probably mediated via increasing plasma miR-24 and miR-126 levels.

show abstract

Section: Discussionsupporting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Gallic Acid Improves Oxidative Stress and Inflammation Through Regulating Micrornas Expressions in the Blood of Diabetic Rats

Badavi

Dianat

et al. 2019

Acta Endo (Buc)

View full text Add to dashboard Cite

show abstract

“…32 Also, GA treatment ameliorates the vasodilatory response of the mesenteric vascular bed to histamine in diabetic rats. 33 The same mechanisms can act in the coronary arteries. In addition, coronary blood flow is normally regulated through cardiac demands for contraction.…”

Section: Discussionmentioning

confidence: 99%

Gallic acid protects against isoproterenol-induced cardiotoxicity in rats

et al. 2022

View full text Add to dashboard Cite

Background Gallic acid (GA) is a polyphenolic agent with interesting pharmacological impacts on the cardiovascular system. Objective The present study purposed to study the protective effects of GA at 25 and 50 mg/kg against isoproterenol (ISO)-induced cardiac damage in ischemia/reperfusion (I/R) in rats. Methods Male Wistar rats were randomly assigned into six groups: Control, Control treated with GA at 25 mg/kg (GA25), Control treated with GA at 50 mg/kg (GA50), Hypertrophic rats induced by ISO (ISO), Hypertrophic rats treated with GA at 25 mg/kg (ISO+GA25), and Hypertrophic rats treated with GA at 50 mg/kg (ISO+GA50). Heart isolation was performed to induce a cardiac I/R injury model. Cardiac hemodynamic parameters were recorded. Serum Lactate Dehydrogenase (LDH) and Creatine Kinase-MB (CK-MB) and cardiac Superoxide dismutases (SOD) levels were evaluated. The gene expression of Sarcoplasmic reticulum Ca2+-ATPase (SERCA2a) was assessed. Results We found that GA at 50 mg/kg was significantly increased cardiac function at post I/R period in ISO-induced hypertrophic hearts. Moreover, it suppressed cardiac hypertrophy, the serum LDH and CK-MB levels in ISO injected rats. Administration of GA at 50 mg/kg was significantly increased SOD level and SERCA2a gene expression in the hypertrophic hearts. Conclusion GA at 50 mg/kg could improve cardiac performance possibly by increasing antioxidant defense enzymes, reducing cell damage, and enhancing SERCA2a gene expression in hypertrophic heart induced by ISO in I/R injury conditions.

show abstract

“…Em estudo do perfil lipídico em pacientes diabéticos, foi avaliada a capacidade do ácido gálico de reduzir a low density lipoprotein (LDL), evitando os danos nas células endoteliais (FERK et al, 2018). Em ratos diabéticos, o ácido gálico influenciou um aumento do relaxamento do leito vascular mesentérico à histamina (BADAVI et al, 2017). Rashid et al (2018) confirmaram ação anti-inflamatória e preventiva da disfunção endotelial em ratos hipertensos e cirróticos, por meio de estudos com extratos da groselha preta contendo ácido gálico.…”

Section: Introductionunclassified

“…(RASHID et al, 2018). Esses estudos não relatam, nitidamente, a contribuição da via do FHDE, mas já é sabido, que os vasodilatadores ON, PGI2 e o FHDE contribuem para o tônus vascular e a reatividade nas artérias(BADAVI et al, 2017).No artigo 5 os autores avaliaram atividade antioxidante vascular in vitro e ex vivo, em artérias mesentéricas superiores de ratos, utilizando extratos de cascas de uvas fermentadas e não fermentadas, constataram que o extrato de uva fermentada teve uma atuação sobre o endotélio desnudo ocasionando seu relaxamento, em conclusão, ocorreu uma atividade antioxidante, confirmaram uma indução ao relaxamento devido à interação do ácido gálico e as vias dependentes do endotélio, o ON e o FHDE(ALBUQUERQUE et al, 2017).…”

unclassified

Efeitos do ácido gálico na resposta vascular: interação com o Fator Hiperpolarizante Derivado do Endotélio (EDHF)

Souza,

Andrade

2022

DS-CS

View full text Add to dashboard Cite

Doenças cardiovasculares ainda são uma das maiores causas de óbito no mundo inteiro e um dos motivos são as alterações endoteliais provocadas, em parte, pela formação de espécies reativas de oxigênio. Nesse contexto, compostos fenólicos que possuem ação antioxidante, como o ácido gálico, destacam-se como agentes promissores na proteção vascular ao estresse oxidativo. Considerando as propriedades terapêuticas do ácido gálico, o presente estudo tem como objetivo avaliar os possíveis efeitos do ácido gálico sobre a resposta vascular e sua influência na estimulação do fator hiperpolarizante derivado do endotélio (FHDE), por meio de uma revisão de literatura de modelos realizados em ex vivo, in vivo e in vitro. Após um refinamento detalhado, seguindo critérios previamente determinados, dez estudos, dentro de um intervalo de 10 anos, foram selecionados na base de dados PubMed. Dos ensaios selecionados, foi possível afirmar que o ácido gálico possui um potente efeito vasorrelaxante e uma melhora do tônus vascular. Os estudos apontaram a interação direta mediada por meio dos vasodilatadores óxido nítrico (ON) e o FHDE. Portanto, foi possível afirmar que o ácido gálico exerce, simultaneamente, um efeito vasorrelaxante dependente do endotélio e um efeito anti-hipertensivo sempre mediado pelas vias ON e FHDE. Este estudo sugere o ácido gálico como uma abordagem terapêutica promissora no tratamento de doenças vasculares; no entanto, as pesquisas demostram a importância de estudos mais aprofundados da relação efetividade com a via do FHDE como também prováveis efeitos quanto à sua toxicidade.

show abstract

Gallic acid improves endothelium‐dependent vasodilatory response to histamine in the mesenteric vascular bed of diabetic rats

Cited by 4 publications

References 36 publications

Gallic Acid Improves Oxidative Stress and Inflammation Through Regulating Micrornas Expressions in the Blood of Diabetic Rats

Gallic Acid Improves Oxidative Stress and Inflammation Through Regulating Micrornas Expressions in the Blood of Diabetic Rats

Gallic acid protects against isoproterenol-induced cardiotoxicity in rats

Efeitos do ácido gálico na resposta vascular: interação com o Fator Hiperpolarizante Derivado do Endotélio (EDHF)

Contact Info

Product

Resources

About