Gallic acid liposomes decorated with lactoferrin: Characterization, in vitro digestion and antibacterial activity

Zhang, Yating; Pu, Chuanfen; Tang, Wenting; Wang, Shi‐Qing; Sun, Qingjie

doi:10.1016/j.foodchem.2019.04.116

Cited by 95 publications

(49 citation statements)

References 39 publications

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“…This results in protein denaturation, poor absorption and inactivation. The inclusion of Lf in preserving structures, such as liposomes, reduces gastric and intestinal denaturation while maintaining its integrity and therefore its biological functionality (Aramaki et al, 1993;Boland, 2016;Ibraheem et al, 2014;Illum, 2002;Kato et al, 1993;Liu et al, 2017;Meshulam and Lesmes, 2014;Zhang et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Lactoferrin as potential supplementary nutraceutical agent in COVID-19 patients:in vitroandin vivopreliminary evidences

Campione

Lanna

Cosio

et al. 2020

Preprint

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The current treatments against SARS-CoV-2 have proved so far inadequate. A potent antiviral drug is yet to be discovered. Lactoferrin, a multifunctional glycoprotein, secreted by exocrine glands and neutrophils, possesses an antiviral activity extendable to SARS-Cov-2. We performed a randomized, prospective, interventional study assessing the role of oral and intra-nasal lactoferrin to treat mild-to-moderate and asymptomatic COVID-19 patients to prevent disease evolution. Lactoferrin induced an early viral clearance and a fast clinical symptoms recovery in addition to a statistically significant reduction of D-Dimer, Interleukin-6 and ferritin blood levels. The antiviral activity of lactoferrin related to its binding to SARS-CoV-2 and cells and protein-protein docking methods, provided the direct recognition between lactoferrin and spike S, thus hindering the spike S attachment to the human ACE2 receptor and consequently virus entering into the cells. Lactoferrin can be used as a safe and efficacious natural agent to prevent and treat COVID-19 infection.

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Section: Discussionmentioning

confidence: 99%

Lactoferrin as potential supplementary nutraceutical agent in COVID-19 patients:in vitroandin vivopreliminary evidences

Campione

Lanna

Cosio

et al. 2020

Preprint

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“…To investigate the bioaccessibility of astaxanthin, the in vitro digestion of astaxanthin was investigated as previously described using a simulated model consisting of the mouth, stomach, and intestine phases [23]. The experiment was conducted at 37 • C and the solution was continuously mixed by magnetic stirring.…”

Section: Determination Of Bioaccessibilitymentioning

confidence: 99%

Effect of Membrane Surface Modification Using Chitosan Hydrochloride and Lactoferrin on the Properties of Astaxanthin-Loaded Liposomes

Qiang

Pang

et al. 2020

Molecules

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Astaxanthin-loaded liposomes were prepared by a thin-film ultrasonic method, and the effects of the different membrane surface modifiers chitosan hydrochloride (CH) and lactoferrin (LF) on the physicochemical stability of the liposomes and bioaccessibility of astaxanthin were studied. Based on the negative charge characteristics of egg yolk lecithin, LF and CH with positive charge were assembled on the surface of liposomes by an electrostatic deposition method. The optimal concentrations of modifiers were determined by particle size, zeta potential and encapsulation efficiency. The interaction between the liposomes and the coatings was characterized by Fourier Transform infrared spectroscopy. The stability of astaxanthin in different systems (suspension and liposomes) was investigated, and its antioxidant capacity and bioaccessibility were determined. The results showed that both membrane surface modifications could interact with liposomes and protect astaxanthin from oxidation or heat degradation and enhance the antioxidant activity of the liposome, therefore membrane surface modification played an important role in stabilizing the lipid bilayer. At the same time, the encapsulated astaxanthin exhibited higher in vitro bioaccessibility than the free astaxanthin. CH and LF modified liposomes can be developed as formulations for encapsulation and delivery of functional ingredients, providing a theoretical basis for the development of new astaxanthin series products.

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“…In a research by Zhang, Pu, et al (2019), XRD was applied to investigate the crystalline structure of gallic acid‐shielding delivery vehicles. The XRD reflections of unloaded gallic acid approved its crystalline lattice (Figure 3a); however, considering the literature, a reduced crystallinity is favorable for gallic acid bioavailability within GI tract location.…”

Section: Xrd: Working Principlesmentioning

confidence: 99%

“…XRD diffractograms of some bioactive‐loaded nanocarriers: (a) gallic acid–liposomes (GA‐LIP), gallic acid lactoferrin (LF), and LF‐GA‐LIP (reprinted with permission from Zhang, Pu et al., 2019); (b) curcumin‐loaded NLCs, NLCs, stearic acid, and curcumin (Reprinted with permission from Behbahani et al., 2019); (c) glyceryl monostearate (A), physical mixture of citral‐glyceryl monostearate (B), and citral‐SLNs (C) (Reprinted with permission from Tian et al., 2018); (d) F2 (carboxymethyl chitosan–PVA [1:2] as shell material and PVP/phospholipids/Car [carvedilol] as core), F5 (sodium carboxymethyl cellulose/PVA [1:2] as shell material and PVP/phospholipids/Car as core), carvedilol, and blank excipient (Reprinted with permission from Chen et al., 2019)…”

Section: Xrd: Working Principlesmentioning

confidence: 99%

Evaluating the structural properties of bioactive‐loaded nanocarriers with modern analytical tools

Rostamabadi

Falsafi

Assadpour

et al. 2020

Comp Rev Food Sci Food Safe

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With the emergence of nanocarriers for offering smart transformers improving the bioavailability and functionality of food bioactive compounds, a critical issue is experimental and analytical evaluation of the bioactive-loaded nanocarriers; so, further technical advancements are necessary for the precise structural characterization of these nanodelivery systems and application of sophisticated analytical techniques. Here, we have portrayed the current progress in the structural characterization approaches including X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, fluorescence spectroscopy, circular dichroism, Fourier-transform infrared spectroscopy, nuclear magnetic resonance, X-ray photoelectron spectroscopy, and small-angle X-ray scattering/small-angle neutron scattering as powerful and informative tools to have a better control on the design, development, and appraisal of nanoengineered bioactive delivery systems. Different examples and case studies have been tabulated along with illustrative and schematic representation of relevant results. An emerging view concerning the challenges for future structural characterization of these systems is also discussed in detail.

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Gallic acid liposomes decorated with lactoferrin: Characterization, in vitro digestion and antibacterial activity

Cited by 95 publications

References 39 publications

Lactoferrin as potential supplementary nutraceutical agent in COVID-19 patients:in vitroandin vivopreliminary evidences

Lactoferrin as potential supplementary nutraceutical agent in COVID-19 patients:in vitroandin vivopreliminary evidences

Effect of Membrane Surface Modification Using Chitosan Hydrochloride and Lactoferrin on the Properties of Astaxanthin-Loaded Liposomes

Evaluating the structural properties of bioactive‐loaded nanocarriers with modern analytical tools

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