Gallic Acid-loaded Cellulose Acetate Electrospun Nanofibers: Thermal Properties, Mechanical Properties, and Drug Release Behavior

Phiriyawirut, Manisara; Phaechamud, Thawatchai

doi:10.4236/ojpchem.2012.21004

Cited by 33 publications

(20 citation statements)

References 27 publications

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“…Some sustained-release formulations of gallic acid like gallic acid-loaded cellulose acetate electrospun nanofibers (44) and gallic acid-loaded electrospun poly(L-lactic acid) fiber (45) were developed and investigated for their in vitro release properties, but sufficient data on the effect of pharmacokinetic parameters are not available. Due to the nontoxic nature of phospholipids, the phospholipid delivery systems are favored than other delivery systems which utilize polymer.…”

Section: Pharmacokinetic Parametersmentioning

confidence: 99%

The Gallic Acid–Phospholipid Complex Improved the Antioxidant Potential of Gallic Acid by Enhancing Its Bioavailability

et al. 2013

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Abstract. Gallic acid (GA) is well known for its antioxidant and hepatoprotective activity, though its effectiveness is restricted due to rapid metabolism and elimination. To overcome these problems, gallic acid-phospholipid complex was prepared and the effect of phospholipid complexation was investigated on carbon tetrachloride (CCl 4 )-induced oxidative damage in rat liver. The complex significantly reduced the hepatic marker enzymes in rat serum and restored the antioxidant enzyme levels with respect to CCl 4 -induced group (P<0.05 and P<0.01). Also, the complex improved the pharmacokinetics of GA by increasing the relative bioavailability and elimination half-life. The study therefore suggests that phospholipid complexation has enhanced the therapeutic efficacy of GA which may be due to its improved absorption and increased bioavailability in rat serum.

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Section: Pharmacokinetic Parametersmentioning

confidence: 99%

The Gallic Acid–Phospholipid Complex Improved the Antioxidant Potential of Gallic Acid by Enhancing Its Bioavailability

et al. 2013

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“…Still, the capacity to design and engineer systems that allow a gradual and continuous release of EOs at concentrations below the cytotoxic, while using the electrospinning technique, has been improving and has already revealed very promising results. In fact, studies have shown that CA-based electrospun nanostructures loaded with EOs to display a higher capacity to retain water and aromatic compounds, thus reducing the initial drug burst and extending release over time, this way increasing the effectiveness of the therapy above other non-reticulated systems [179,180]. Table 7 presents some of the most recent EOs loaded electrospun systems containing cellulose, CA or nanocellulose formulations, in which the above-mentioned properties and outcomes are the most noticeable.…”

Section: Natural Extractsmentioning

confidence: 99%

Electrospun Nanocomposites Containing Cellulose and Its Derivatives Modified with Specialized Biomolecules for an Enhanced Wound Healing

et al. 2020

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Wound healing requires careful, directed, and effective therapies to prevent infections and accelerate tissue regeneration. In light of these demands, active biomolecules with antibacterial properties and/or healing capacities have been functionalized onto nanostructured polymeric dressings and their synergistic effect examined. In this work, various antibiotics, nanoparticles, and natural extract-derived products that were used in association with electrospun nanocomposites containing cellulose, cellulose acetate and different types of nanocellulose (cellulose nanocrystals, cellulose nanofibrils, and bacterial cellulose) have been reviewed. Renewable, natural-origin compounds are gaining more relevance each day as potential alternatives to synthetic materials, since the former undesirable footprints in biomedicine, the environment, and the ecosystems are reaching concerning levels. Therefore, cellulose and its derivatives have been the object of numerous biomedical studies, in which their biocompatibility, biodegradability, and, most importantly, sustainability and abundance, have been determinant. A complete overview of the recently produced cellulose-containing nanofibrous meshes for wound healing applications was provided. Moreover, the current challenges that are faced by cellulose acetate- and nanocellulose-containing wound dressing formulations, processed by electrospinning, were also enumerated.

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“…Cellulose acetate (CA) fibres and membranes have important biomedical applications in affinity membranes and drug delivery [1]. The development of experimental biomedical products continues to involve solution blending of the polymer with other therapeutic molecules and compounds.…”

Section: Introductionmentioning

confidence: 99%

“…Research has led to the fabrication of various functional materials including antibacterial CA nanofibres containing AgNO3 [2], nanofibres for therapeutic delivery of active compounds, such as vitamins A and E [3], curcumin [4], nicotine [5], naproxen [6], gallic acid [1], gingerol [7], tetracycline hydrochloride [8], ketoprofen [9], the assembly of topical drug delivery carriers containing non-steroidal anti-inflammatory drugs (NSAIDs) [10], and edible nanofibrous films containing egg albumen [11].…”

Section: Introductionmentioning

confidence: 99%

Enrichment of cellulose acetate nanofibre assemblies for therapeutic delivery of l-tryptophan

Ghorani

Goswami²,

Blackburn

et al. 2018

International Journal of Biological Macromolecules

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The essential amino acid l-tryptophan is naturally present in the body, and is also available as a water soluble dietary supplement. The feasibility of preparing enriched cellulose acetate (CA)-based fibres as a vehicle for therapeutic delivery of such biomolecules was investigated. A new ternary solvent system consisting of acetone: N,N-dimethylacetamide: methanol (2:1:2) has been demonstrated to permit the solution blending of CA with the water soluble l-tryptophan. Nanofibrous webs substantially free of structural defects were continuously produced with mean fibre diameters in the range of 520-1010nm, dependent on process parameters. Morphology and diameter of fibres were influenced by concentration of CA spinning solution, applied voltage and flow rates. The kinetic release profile of l-tryptophan from electrospun CA nanofibres was described by the pseudo-second order kinetic model. Fibres with mean diameter of 720nm provide both the highest initial desorption rate and rate constant, which was partially attributed to the low fibre diameter and high relative surface area, but also the fact that the 720nm fibres produced were the most bead-free, providing diffusion advantages over the fibres with lowest mean diameter (520nm). The feasibility of combining l-tryptophan within fibres provides a promising route for manufacture of transdermal delivery devices.

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Gallic Acid-loaded Cellulose Acetate Electrospun Nanofibers: Thermal Properties, Mechanical Properties, and Drug Release Behavior

Cited by 33 publications

References 27 publications

The Gallic Acid–Phospholipid Complex Improved the Antioxidant Potential of Gallic Acid by Enhancing Its Bioavailability

The Gallic Acid–Phospholipid Complex Improved the Antioxidant Potential of Gallic Acid by Enhancing Its Bioavailability

Electrospun Nanocomposites Containing Cellulose and Its Derivatives Modified with Specialized Biomolecules for an Enhanced Wound Healing

Enrichment of cellulose acetate nanofibre assemblies for therapeutic delivery of l-tryptophan

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