Gallic acid‐loaded electrospun cellulose acetate nanofibers as potential wound dressing materials

Abstract

Gallic acid (GA)–loaded cellulose acetate (CA) nanofiber mats with 10 to 40 wt.% GA contents (based on the weight of CA) were fabricated by electrospinning. The effects of GA contents and applied potential on the morphology and the average diameters of fibers were studied. The electrospun fiber mats containing 20 and 40 wt.% GA were investigated for their potential use as carrier of GA in wound dressing application. The GA‐loaded CA films were prepared by solvent casting technique for use in comparative studies. Determination of the release characteristics of GA from the GA‐loaded fiber mats and films was carried out by the total immersion and the transdermal diffusion through a pig skin method in acetate buffer solution (pH 5.5) or normal saline (pH 7.0) at either 32 or 37°C, respectively. In the total immersion method, the maximum amounts of the GA released from the fiber mats containing 20 and 40 wt.% GA in the acetate buffer were approximately 97% and 71% (based on the weight of initial GA), while those of the GA released into the normal saline were approximately 96% and 81%, respectively. Lower values were observed in the experiments of the transdermal diffusion through a pig skin method. The corresponding GA‐loaded CA films showed the lower amounts of GA released into media. The as‐loaded and the as‐released GA remained its antioxidant activity as investigated by 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) assay. Lastly, the GA‐loaded CA fiber mats exhibited antibacterial activity against Staphylococcus aureus, which showed the potential for use as wound dressing materials.

Post Processing Strategies for the Enhancement of Mechanical Properties of ENMs (Electrospun Nanofibrous Membranes): A Review

“…This range can be termed as the processing window or optimum range beyond which electrospinning is not possible. Many applications of electrospun fibers and membranes include biomedical (tissue engineering [12][13][14], drug delivery [15][16][17], immobilization of enzymes [18][19][20], wound dressing [21][22][23] and antibacterial membranes [24][25][26]), textiles [27][28][29], separation membranes (Li ion battery separators [30][31][32], distillation [33][34][35] and filtration membranes [36][37][38]), sensors [39][40][41], and high performance composite materials (reinforcing agents [42][43][44] or vascular networks of healing agents [45][46][47]), etc.…”

Collagen-Based Materials Modified by Phenolic Acids—A Review

“…Gallic acid addition to starch was studied as beneficial to control starch product digestion [137]. It was also studied as a cross-linker for cellulose [138].…”

Biodegradable CA/CPB electrospun nanofibers for efficient retention of airborne nanoparticles

“…Cellulose acetate (CA) is a semi-synthetic and biodegradable polymer ( Buchanan et al, 1993 ; Puls et al, 2011 ) widely used to produce nanofibers by electrospinning ( Anitha et al, 2013 ; Nicosia et al, 2016 ; Sultana and Zainal, 2016 ; Wutticharoenmongkol et al, 2019 ). Due to the common presence of beads in their fibers, thermal and mechanical resistance properties are compromised ( Kendouli et al, 2014 ).…”