Gallic acid modulates purine metabolism and oxidative stress induced by ethanol exposure in zebrafish brain

Baldin, Samira Leila; Pickler, Karolyne de Pieri; Farias, Ana Caroline Salvador de; Bernardo, Henrique Teza; Scussel, Rahisa; Pereira, Bárbara da Costa; Pacheco, Suzielen Damin; Dondossola, Eduardo Ronconi; Machado-de-Ávila, Ricardo Andrez; Wanderley, Almir Gonçalves; Rico, Eduardo Pacheco

doi:10.1007/s11302-022-09869-z

Cited by 5 publications

(1 citation statement)

References 54 publications

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“…On the other hand, animals co-treated with EchEE besides to BIF showed a significant increase in AChE activity, as well as dopamine and serotonin levels, in both cortex and hippocampus in compared to BIF –treated rats. Velíšek ( 2006 ) stated that Echinacea extract counteracted dopamine, acetylcholine, opioids, and the GABAergic system in the brain; interestingly, Konishi et al ( 2005 ) , Woelkart et al ( 2009 ) and Baldin et al ( 2022 ) attributed this effect to the active components inside the extract such as cafeic acid, rosmarinic acid, and gallic acid that can easily pass through the blood–brain barrier and exert their protective effect. Also, results of Zhang et al ( 2023 ) revealed that the naringenin and apigenin treatment counteracted corticosterone-induced depressive behaviors by elevating the levels of 5- serotonin, dopamine and norepinephrine in the hippocampus.…”

Section: Discussionmentioning

confidence: 99%

Echinacea purpurea extract intervention for counteracting neurochemical and behavioral changes induced by bifenthrin

Abdel-Wahhab,

Sayed,

EL-Sahra

et al. 2023

Metab Brain Dis

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This study was conducted to elucidate the possible protective efficiency of Echinacea purpurea hydroethanolic extract (EchEE) against bifenthrin (BIF)-induced neuro-chemical and behavioral changes in rats. Total phenolics content, reducing power and radical scavenging activity of EchEE were estimated. Four groups of adult male albino rats were used (10 rats each) as follows: 1) Control healthy rats ingested with placebo, 2) Healthy rats orally received EchEE (465 mg/kg/day), 3) Rats intoxicated with BIF (7mg/kg/day) dissolved in olive oil, and 4) Rats co-treated with EchEE (465 mg/kg/day) besides to BIF (7mg/kg/day) intoxication. After 30 days, some neuro-chemical and behavioral tests were assessed. The behavioral tests revealed that rats received BIF exhibited exploratory behavior and spatial learning impairments, memory and locomotion dysfunction, and enhanced anxiety level. Biochemical findings revealed that BIF induced-oxidative stress in the cortex and hippocampus; this was appeared from the significant rise in malondialdehyde (MDA) and nitric oxide (NO) levels, coupled with decreased catalase (CAT), superoxide dismutase (SOD), paraoxonase-1 (PON-1) activities, and reduced glutathione (GSH) level in both brain areas. Also, BIF induced a significant increase caspas-3, tumor necrosis factor alpha (TNF), and interleukin-1beta (IL-1ß) in both areas; dopamine and serotonin levels, and ACh-ase activity were markedly decreased in both areas. Interestingly, treatment of rats with EchEE in combination with BIF resulted in a significant decrease in oxidative stress damage, and modulation of the apoptotic and pro-inflammatory markers. Also, EchEE markedly improved behavioral activities and neurotransmitters level that were impaired by BIF. In conclusion, the present study clearly indicated that EchEE can attenuate brain dysfunction induced by pesticides exposure through preventing the oxidative stress. This may be attributed to its high antioxidant component.

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