Gallic acid protects against bisphenol A-induced alterations in the cardio-renal system of Wistar rats through the antioxidant defense mechanism

Ola‐Davies, Olufunke Eunice; Olukole, Samuel Gbadebo

doi:10.1016/j.biopha.2018.08.108

Cited by 40 publications

(31 citation statements)

References 43 publications

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“…Intraperitoneal administration of gallic acid in rats treated with gentamicin significantly decreased NO ( 38 ). Also, the administration of gallic acid in Wistar male rats treated with bisphenol-A significantly decreased serum NO levels ( 39 ).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of gallic acid on nicotine-induced testicular toxicity in mice

Jalili

Korani

Pazhouhi

et al. 2021

Research in Pharmaceutical Sciences

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Background and purpose: Nicotine is an alkaloid found in many nutrients and tobacco that can cause infertility in men. Gallic acid is a powerful antioxidant that possesses antimutagenic and anticancer activities. This study aimed to determine the potential protective effect of gallic acid against nicotine-induced testicular toxicity in male mice. Experimental approach: In this in vivo study, forty-eight mice were equally divided into eight groups intraperitoneally receiving normal saline (control), nicotine (0.6 mg/kg), gallic acid (5, 10, and 15 mg/kg), and gallic acid (5, 10, and 15 mg/kg) plus nicotine. Nicotine was injected intraperitoneally for 14 days and gallic acid was administered concomitantly with nicotine and continued for 7 days later. Then, body and testicular weights, the sperm parameters (viability, number, motility, and morphology of sperm), and testicular histology were evaluated. Also, serum levels of nitric oxide, total antioxidant, superoxide dismutase, malondialdehyde, and testosterone were measured. Findings/Results: The results showed that the administration of nicotine significantly reduced testis and body weight, sperm count, viability, normal morphology and motility, seminiferous tubules diameter, testosterone levels, serum levels of total antioxidants, and superoxide dismutase compared to the control group ( P < 0.05). It also significantly increased the level of nitric oxide and malondialdehyde ( P < 0.05). Increasing the dose of gallic acid along with nicotine significantly increased body weight, sperm count, viability, normal morphology and motility, the diameter of seminiferous, testosterone concentration, total antioxidant levels ( P < 0.05). This combination also significantly decreased malondialdehyde and nitric oxide levels compared to the nicotine-receiving group ( P < 0.05). Conclusion and implications: Gallic acid had a protective effect on nicotine-induced testicular toxicity in mice. It can neutralize the harmful effect of nicotine on male fertility in smokers.

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Section: Discussionmentioning

confidence: 99%

Protective effect of gallic acid on nicotine-induced testicular toxicity in mice

Jalili

Korani

Pazhouhi

et al. 2021

Research in Pharmaceutical Sciences

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“…Several relative literatures had reported that paeonol induced many pharmacological effects through inhibiting oxidative stress (Qin et al, 2010;Bao et al, 2013;Gong et al, 2017). As a member of a polyphenol family, gallic acid is considered to be one of the most abundant sources of nature antioxidants (Roidoung et al, 2016;Rajan and Muraleedharan, 2017;Ola-Davies and Olukole, 2018). Benzoylpaeoniflorin, as a monoterpene glycoside, also has been proved as a strong antioxidant from related studies (Fang et al, 2008;Xu et al, 2017).…”

Section: Paeonol Gallic Acid and Benzoylpaeoniflorin Were Evaluated As Potent Antioxidants By Grey Relational Analysismentioning

confidence: 99%

Grey Relational Analysis Combined With Network Pharmacology to Identify Antioxidant Components and Uncover Its Mechanism From Moutan Cortex

Zhang

Wang

et al. 2021

Front. Pharmacol.

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The present study determines the potential antioxidants in Moutan Cortex (MC) and predicts its targets of anti-oxidative activities. The quantitative analysis and the free radical scavenging assays were conducted to detect the main components in MC and assess its anti-oxidant activities. The grey relational analysis and the network pharmacology approach were employed to predict its key components and targets of anti-oxidant activities. Six main constitutes in MCs were quantified by high performance liquid chromatography (HPLC) and its anti-oxidant activities were evaluated by DPPH and ABTS free radical scavenging methods. Then grey relational analysis was employed to predict the key components acting on anti-oxidative activity based on the chem-bio results. The predicted components and its mechanisms on anti-oxidation were uncovered by network pharmacology approach and cell test, respectively. The content of paeonol and paeoniflorin accounts for more than 80% the whole content of detected components. However, the two main ingredients showed a great variety among MCs. The antioxidant capacities of MCs also showed a great discrepancy based on DPPH and ABTS methods. The key components acting on anti-oxidation were identified to be paeonol, gallic acid and benzoylpaeoniflorin, and their potential therapeutic targets were predicted and verified, respectively. The present results reveal that MC has a significant antioxidant activity and the compounds of paeonol, gallic acid and benzoylpaeoniflorin could be considered as the promising antioxidant candidates with the property of suppressing oxidative stress and apoptosis.

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“…Free-radical scavenging property of MLT might protect against the adverse effects of EDCs on testicular function and spermatogenesis due reducing oxidative damage and controlling the levels of the antioxidant enzymes [ 7 – 11 ]. Previous reports have demonstrated that antioxidants such as lipoic acid [ 12 ], N-acetylcysteine [ 13 ], vitamin C [ 14 ], and gallic acid [ 15 ] could prevent or reduce the EDC-induced toxicity effects. The ameliorative role of MLT has been reported in EDC-induced biochemical toxicity in testicular mitochondria of adult mice [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Melatonin on Nonylphenol-Induced Reproductive and Behavioral Disorders in First-Generation Adult Male Rats

Tavakoli

Moghadamnia

Pourabdolhossein

et al. 2022

Behavioural Neurology

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Background and Objective. Nonylphenol (NP), as an environmental pollutant, has adverse effects on the reproductive and nervous systems through disrupting the endocrine system and inducing oxidative stress. This study was aimed at investigating the protective effect of melatonin (MLT) on NP-induced reproductive and behavioral disorders in first-generation adult male rats. Methods. Pregnant Wistar rats were randomly assigned into five groups: control, NP (25 mg/kg), NP (25 mg/kg)+MLT (10 mg/kg), NP (25 mg/kg)+MLT (20 mg/kg), and MLT (20 mg/kg). The duration of treatment was 21 days from gestation time. Morris water maze was used to assess learning and memory. NP concentrations of serum and testicular tissue were measured by HPLC. Histological analysis of testicular tissues was done by H&E staining. Results. Behavioral study showed that NP does not impair learning and memory in first-generation rats. Histomorphometric results showed that NP can significantly reduce the cross-sectional area of the seminiferous tubules and the epithelium, the diameter and number of seminiferous tubules, the thickness of the epithelium, and the number of spermatocytes and spermatogonia compared to other groups. MLT reversed the NP-induced histomorphometric. Also, it changes and increased the activity of superoxide dismutase (SOD), total antioxidant capacity (TAC), and catalase (CAT). The level of malondialdehyde (MDA) significantly decreased in MLT-treated groups compared with the NP group. Conclusion. Our finding showed that MLT enhanced the learning process and reduced NP-induced testicular tissue damage through its antioxidants and cytoprotective effects.

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Gallic acid protects against bisphenol A-induced alterations in the cardio-renal system of Wistar rats through the antioxidant defense mechanism

Cited by 40 publications

References 43 publications

Protective effect of gallic acid on nicotine-induced testicular toxicity in mice

Protective effect of gallic acid on nicotine-induced testicular toxicity in mice

Grey Relational Analysis Combined With Network Pharmacology to Identify Antioxidant Components and Uncover Its Mechanism From Moutan Cortex

Protective Effect of Melatonin on Nonylphenol-Induced Reproductive and Behavioral Disorders in First-Generation Adult Male Rats

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