Gallic Acid Reduces Blood Pressure and Attenuates Oxidative Stress and Cardiac Hypertrophy in Spontaneously Hypertensive Rats

Jin, Li; Piao, Zhe; Sun, Simei; Liu, Bin; Kim, Gwi Ran; Seok, Young Mi; Lin, Ming Quan; Ryu, Yuhee; Choi, Sin Young; Kee, Hae Jin; Cho, Jeong Gwan

doi:10.1038/s41598-017-15925-1

Cited by 88 publications

(62 citation statements)

References 60 publications

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“…It has been demonstrated that oxidative stress plays an important role in cardiac hypertrophy and remodeling (Jin et al, ; Seddon, Looi, & Shah, ). To elucidate the potential role of FoxO3 in PQ‐induced cardiac damage, we generated cardiomyocyte‐specific FoxO3 knockout (CKO) mice by crossing FoxO3 f/f with Myh6‐Cre mice (Figure A).…”

Section: Resultsmentioning

confidence: 99%

Forkhead box O3 protects the heart against paraquat‐induced aging‐associated phenotypes by upregulating the expression of antioxidant enzymes

Chang

Xia

et al. 2019

Aging Cell

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Paraquat (PQ) promotes cell senescence in brain tissue, which contributes to Parkinson's disease. Furthermore, PQ induces heart failure and oxidative damage, but it remains unknown whether and how PQ induces cardiac aging. Here, we demonstrate that PQ induces phenotypes associated with senescence of cardiomyocyte cell lines and results in cardiac aging‐associated phenotypes including cardiac remodeling and dysfunction in vivo. Moreover, PQ inhibits the activation of Forkhead box O3 (FoxO3), an important longevity factor, both in vitro and in vivo. We found that PQ‐induced senescence phenotypes, including proliferation inhibition, apoptosis, senescence‐associated β‐galactosidase activity, and p16INK4a expression, were significantly enhanced by FoxO3 deficiency in cardiomyocytes. Notably, PQ‐induced cardiac remolding, apoptosis, oxidative damage, and p16INK4a expression in hearts were exacerbated by FoxO3 deficiency. In addition, both in vitro deficiency and in vivo deficiency of FoxO3 greatly suppressed the activation of antioxidant enzymes including catalase (CAT) and superoxide dismutase 2 (SOD2) in the presence of PQ, which was accompanied by attenuation in cardiac function. The direct in vivo binding of FoxO3 to the promoters of the Cat and Sod2 genes in the heart was verified by chromatin immunoprecipitation (ChIP). Functionally, overexpression of Cat or Sod2 alleviated the PQ‐induced senescence phenotypes in FoxO3‐deficient cardiomyocyte cell lines. Overexpression of FoxO3 and CAT in hearts greatly suppressed the PQ‐induced heart injury and phenotypes associated with aging. Collectively, these results suggest that FoxO3 protects the heart against an aging‐associated decline in cardiac function in mice exposed to PQ, at least in part by upregulating the expression of antioxidant enzymes and suppressing oxidative stress.

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Section: Resultsmentioning

confidence: 99%

Forkhead box O3 protects the heart against paraquat‐induced aging‐associated phenotypes by upregulating the expression of antioxidant enzymes

Chang

Xia

et al. 2019

Aging Cell

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“…Protocatechuic acid is known as having suppressive effect on TNBS-induced colitis [ 15 ], preventive effect on LPS-induced inflammatory response in fibroblast [ 16 ], and anti-oxidative effect [ 17 ]. In addition, gallic acid has several effects on allergic reaction [ 18 ], type 2 diabetes symptoms [ 19 ], oxidative stress, and hypertension [ 20 ]. These constituents (protocatetuic acid and gallic acid) might influence the regulatory effect of ES on P.acnes -induced ear inflammation.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effects of Euphorbia supina on Propionibacterium acnes-induced skin inflammation in vitro and in vivo

Lim

Jeon

Kang

et al. 2018

BMC Complement Altern Med

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BackgroundEuphorbia supina (ES) plant has been used as treatment for inflammatory conditions. The antibacterial effect and the anti-inflammatory mechanism of ES for Propionibacterium (P.) acnes-induced inflammation in THP-1 cells and acne animal model remain unclear. Therefore, the objective of the present study was to determine the antibacterial and anti-inflammatory activities of ES against P. acnes, the etiologic agent of skin inflammation.MethodThe antibacterial activities of ES were tested with disc diffusion and broth dilution methods. Cytotoxicity of ES at different doses was evaluated by the MTT assay. THP-1 cells were stimulated by heat-killed P. acnes in the presence of ES. The pro-inflammatory cytokines and mRNA levels were measured by ELISA and real-time-PCR. MAPK expression was analyzed by Western blot. The living P. acnes was intradermally injected into the ear of BLBC/c mice. Subsequently, chemical composition of ES was analyzed by liquids chromatography-mass spectrometry (LC-MS).ResultES had stronger antibacterial activity against P. acnes and inhibitory activity on lipase. ES had no significant cytotoxicity on THP-1 cells. ES suppressed the mRNA levels and production of IL-8, TNF-a, IL-1β in vitro. ES inhibited the expression levels of pro-inflammatory cytokines and the MAPK signaling pathway. Ear thickness and inflammatory cells were markedly reduced by ES treatment. Protocatechuic acid, gallic acid, quercetin, and kaempferol were detected by LC-MS analysis in ES.ConclusionsOur results demonstrate antibacterial and anti-inflammatory activities of ES extract against P. acnes. It is suggested that ES extract might be used to treatment anti-inflammatory skin disease.Electronic supplementary materialThe online version of this article (10.1186/s12906-018-2320-8) contains supplementary material, which is available to authorized users.

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“…There are many natural sources of GA, either in its free state or as part of tannin molecules in various fruits (Kuppan et al, ; Li, Liu, Zhao, Xi, & Niu, ). Furthermore, GA also has anti‐mutagenic, anti‐carcinogenic, anti‐allergic and anti‐bacterial abilities (Li et al, ) and has important roles in the cerebral antioxidant system (Naghizadeh & Mansouri, ) and in mitigating cardiac hypertrophy (Jin et al, ).…”

Section: Introductionmentioning

confidence: 99%

Gallic and carnosic acids improve quality of frozen‐thawed ram spermatozoa

et al. 2019

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The objective was to determine effects of gallic acid (GA) and carnosic acid (CA), present in carob pods and rosemary extract respectively, on frozen-thawed ram spermatozoa. Thirty ejaculates were collected from five Merino rams, pooled, diluted in Tris-based extender and divided into five equal portions containing: 0.05 or 2 mM of GA; 0.05 or 0.2 mM of CA; or no additive (control). Extended semen was equilibrated at +4°C, loaded into straws, held 5 cm above liquid nitrogen for 12 min then plunged.Computer-aided sperm analysis was used to assess motility, whereas flow cytometry

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Gallic Acid Reduces Blood Pressure and Attenuates Oxidative Stress and Cardiac Hypertrophy in Spontaneously Hypertensive Rats

Cited by 88 publications

References 60 publications

Forkhead box O3 protects the heart against paraquat‐induced aging‐associated phenotypes by upregulating the expression of antioxidant enzymes

Forkhead box O3 protects the heart against paraquat‐induced aging‐associated phenotypes by upregulating the expression of antioxidant enzymes

Inhibitory effects of Euphorbia supina on Propionibacterium acnes-induced skin inflammation in vitro and in vivo

Gallic and carnosic acids improve quality of frozen‐thawed ram spermatozoa

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